| Full name: potassium voltage-gated channel subfamily H member 2 | Alias Symbol: Kv11.1|HERG|erg1 | ||
| Type: protein-coding gene | Cytoband: 7q36.1 | ||
| Entrez ID: 3757 | HGNC ID: HGNC:6251 | Ensembl Gene: ENSG00000055118 | OMIM ID: 152427 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNH2 | 3757 | 210036_s_at | -1.1063 | 0.1197 | |
| GSE20347 | KCNH2 | 3757 | 210036_s_at | 0.0252 | 0.8575 | |
| GSE23400 | KCNH2 | 3757 | 210036_s_at | -0.2853 | 0.0003 | |
| GSE26886 | KCNH2 | 3757 | 210036_s_at | 0.5645 | 0.0009 | |
| GSE29001 | KCNH2 | 3757 | 210036_s_at | -0.0410 | 0.8876 | |
| GSE38129 | KCNH2 | 3757 | 210036_s_at | -0.2922 | 0.2545 | |
| GSE45670 | KCNH2 | 3757 | 205262_at | -0.0974 | 0.4224 | |
| GSE53622 | KCNH2 | 3757 | 93306 | -1.3322 | 0.0000 | |
| GSE53624 | KCNH2 | 3757 | 93306 | -0.9321 | 0.0000 | |
| GSE63941 | KCNH2 | 3757 | 210036_s_at | 0.1581 | 0.8261 | |
| GSE77861 | KCNH2 | 3757 | 210036_s_at | 0.0017 | 0.9897 | |
| GSE97050 | KCNH2 | 3757 | A_23_P377882 | -0.2117 | 0.7032 | |
| SRP064894 | KCNH2 | 3757 | RNAseq | 0.2944 | 0.5375 | |
| SRP133303 | KCNH2 | 3757 | RNAseq | -0.4001 | 0.5138 | |
| SRP159526 | KCNH2 | 3757 | RNAseq | -0.5553 | 0.2633 | |
| SRP219564 | KCNH2 | 3757 | RNAseq | -1.0078 | 0.3911 | |
| TCGA | KCNH2 | 3757 | RNAseq | -0.9003 | 0.0037 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KCNH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNH2 | 3757 | 2 | 4 | 24 | |
| GSE20123 | KCNH2 | 3757 | 2 | 4 | 24 | |
| GSE43470 | KCNH2 | 3757 | 2 | 5 | 36 | |
| GSE46452 | KCNH2 | 3757 | 7 | 2 | 50 | |
| GSE47630 | KCNH2 | 3757 | 5 | 9 | 26 | |
| GSE54993 | KCNH2 | 3757 | 3 | 3 | 64 | |
| GSE54994 | KCNH2 | 3757 | 5 | 8 | 40 | |
| GSE60625 | KCNH2 | 3757 | 0 | 0 | 11 | |
| GSE74703 | KCNH2 | 3757 | 2 | 4 | 30 | |
| GSE74704 | KCNH2 | 3757 | 1 | 4 | 15 | |
| TCGA | KCNH2 | 3757 | 26 | 26 | 44 |
Total number of gains: 55; Total number of losses: 69; Total Number of normals: 364.
Somatic mutations of KCNH2:
Generating mutation plots.
Highly correlated genes for KCNH2:
Showing top 20/751 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNH2 | MYADM | 0.791757 | 3 | 0 | 3 |
| KCNH2 | PPP1R14A | 0.770634 | 5 | 0 | 5 |
| KCNH2 | RBFOX3 | 0.764568 | 3 | 0 | 3 |
| KCNH2 | HMCN1 | 0.7626 | 3 | 0 | 3 |
| KCNH2 | SH3BGR | 0.756377 | 6 | 0 | 6 |
| KCNH2 | CORO6 | 0.744281 | 3 | 0 | 3 |
| KCNH2 | PRR26 | 0.742562 | 3 | 0 | 3 |
| KCNH2 | SORCS1 | 0.741703 | 4 | 0 | 4 |
| KCNH2 | ADAMTS9-AS2 | 0.740482 | 3 | 0 | 3 |
| KCNH2 | CYP21A2 | 0.73278 | 3 | 0 | 3 |
| KCNH2 | MYOCD | 0.72478 | 5 | 0 | 5 |
| KCNH2 | PPP1R12B | 0.712579 | 7 | 0 | 7 |
| KCNH2 | ANTXR2 | 0.71142 | 3 | 0 | 3 |
| KCNH2 | SMOC2 | 0.710821 | 5 | 0 | 5 |
| KCNH2 | PYGM | 0.709239 | 8 | 0 | 8 |
| KCNH2 | PTCHD1 | 0.708655 | 5 | 0 | 4 |
| KCNH2 | PARD3B | 0.703923 | 4 | 0 | 4 |
| KCNH2 | PDE5A | 0.702081 | 7 | 0 | 7 |
| KCNH2 | ARHGAP6 | 0.698419 | 7 | 0 | 7 |
| KCNH2 | ANGPTL1 | 0.698334 | 4 | 0 | 3 |
For details and further investigation, click here
