| Full name: SH3 domain binding glutamate rich protein | Alias Symbol: 21-GARP | ||
| Type: protein-coding gene | Cytoband: 21q22.2 | ||
| Entrez ID: 6450 | HGNC ID: HGNC:10822 | Ensembl Gene: ENSG00000185437 | OMIM ID: 602230 |
| Drug and gene relationship at DGIdb | |||
Expression of SH3BGR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3BGR | 6450 | 204979_s_at | -1.1956 | 0.2146 | |
| GSE20347 | SH3BGR | 6450 | 204979_s_at | -0.0990 | 0.6282 | |
| GSE23400 | SH3BGR | 6450 | 204979_s_at | -0.3288 | 0.0000 | |
| GSE26886 | SH3BGR | 6450 | 204979_s_at | 0.1273 | 0.7188 | |
| GSE29001 | SH3BGR | 6450 | 204979_s_at | -0.0146 | 0.9730 | |
| GSE38129 | SH3BGR | 6450 | 204979_s_at | -0.6585 | 0.0770 | |
| GSE45670 | SH3BGR | 6450 | 204979_s_at | -1.6313 | 0.0000 | |
| GSE53622 | SH3BGR | 6450 | 15233 | -1.6721 | 0.0000 | |
| GSE53624 | SH3BGR | 6450 | 15233 | -1.4139 | 0.0000 | |
| GSE63941 | SH3BGR | 6450 | 204979_s_at | -1.2747 | 0.0264 | |
| GSE77861 | SH3BGR | 6450 | 204979_s_at | -0.0799 | 0.6312 | |
| GSE97050 | SH3BGR | 6450 | A_33_P3327822 | -1.1692 | 0.1516 | |
| SRP064894 | SH3BGR | 6450 | RNAseq | -0.9123 | 0.0144 | |
| SRP133303 | SH3BGR | 6450 | RNAseq | -1.1539 | 0.0291 | |
| SRP159526 | SH3BGR | 6450 | RNAseq | -1.0986 | 0.0207 | |
| SRP219564 | SH3BGR | 6450 | RNAseq | -1.5408 | 0.0748 | |
| TCGA | SH3BGR | 6450 | RNAseq | -1.0078 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by SH3BGR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3BGR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3BGR | 6450 | 2 | 11 | 17 | |
| GSE20123 | SH3BGR | 6450 | 2 | 11 | 17 | |
| GSE43470 | SH3BGR | 6450 | 0 | 10 | 33 | |
| GSE46452 | SH3BGR | 6450 | 1 | 21 | 37 | |
| GSE47630 | SH3BGR | 6450 | 6 | 17 | 17 | |
| GSE54993 | SH3BGR | 6450 | 8 | 1 | 61 | |
| GSE54994 | SH3BGR | 6450 | 3 | 9 | 41 | |
| GSE60625 | SH3BGR | 6450 | 0 | 0 | 11 | |
| GSE74703 | SH3BGR | 6450 | 0 | 8 | 28 | |
| GSE74704 | SH3BGR | 6450 | 1 | 7 | 12 | |
| TCGA | SH3BGR | 6450 | 8 | 41 | 47 |
Total number of gains: 31; Total number of losses: 136; Total Number of normals: 321.
Somatic mutations of SH3BGR:
Generating mutation plots.
Highly correlated genes for SH3BGR:
Showing top 20/1086 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3BGR | UBXN10 | 0.864782 | 3 | 0 | 3 |
| SH3BGR | SORCS1 | 0.842212 | 4 | 0 | 4 |
| SH3BGR | PTCHD1 | 0.838718 | 5 | 0 | 5 |
| SH3BGR | MBNL1-AS1 | 0.824299 | 3 | 0 | 3 |
| SH3BGR | MORN5 | 0.822647 | 3 | 0 | 3 |
| SH3BGR | NEGR1 | 0.81689 | 6 | 0 | 6 |
| SH3BGR | ATP1A2 | 0.815017 | 8 | 0 | 8 |
| SH3BGR | PYGM | 0.813455 | 8 | 0 | 8 |
| SH3BGR | CYP21A2 | 0.811894 | 3 | 0 | 3 |
| SH3BGR | RBFOX3 | 0.808216 | 3 | 0 | 3 |
| SH3BGR | NCAM1 | 0.803959 | 7 | 0 | 7 |
| SH3BGR | C1QTNF7 | 0.794427 | 5 | 0 | 5 |
| SH3BGR | ADAMTSL1 | 0.793193 | 5 | 0 | 5 |
| SH3BGR | KCNMB1 | 0.787919 | 9 | 0 | 9 |
| SH3BGR | CFL2 | 0.78704 | 5 | 0 | 5 |
| SH3BGR | SMTN | 0.785622 | 7 | 0 | 6 |
| SH3BGR | CLEC3B | 0.779612 | 3 | 0 | 3 |
| SH3BGR | SGCA | 0.77449 | 8 | 0 | 7 |
| SH3BGR | AOC3 | 0.772611 | 8 | 0 | 7 |
| SH3BGR | SMOC2 | 0.771942 | 5 | 0 | 5 |
For details and further investigation, click here
