| Full name: DNA polymerase eta | Alias Symbol: RAD30A|XP-V | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 5429 | HGNC ID: HGNC:9181 | Ensembl Gene: ENSG00000170734 | OMIM ID: 603968 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of POLH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLH | 5429 | 222879_s_at | -0.0736 | 0.7939 | |
| GSE20347 | POLH | 5429 | 219380_x_at | -0.2308 | 0.0618 | |
| GSE23400 | POLH | 5429 | 219380_x_at | -0.0451 | 0.0112 | |
| GSE26886 | POLH | 5429 | 222879_s_at | 0.0197 | 0.9323 | |
| GSE29001 | POLH | 5429 | 219380_x_at | 0.0054 | 0.9769 | |
| GSE38129 | POLH | 5429 | 219380_x_at | -0.0877 | 0.6507 | |
| GSE45670 | POLH | 5429 | 233852_at | -0.0121 | 0.9507 | |
| GSE53622 | POLH | 5429 | 143770 | -0.2437 | 0.0068 | |
| GSE53624 | POLH | 5429 | 143770 | 0.0625 | 0.5403 | |
| GSE63941 | POLH | 5429 | 222879_s_at | 0.6016 | 0.1512 | |
| GSE77861 | POLH | 5429 | 219380_x_at | -0.2110 | 0.1016 | |
| GSE97050 | POLH | 5429 | A_32_P96692 | -0.2081 | 0.4101 | |
| SRP007169 | POLH | 5429 | RNAseq | -0.3414 | 0.3188 | |
| SRP008496 | POLH | 5429 | RNAseq | -0.1292 | 0.5538 | |
| SRP064894 | POLH | 5429 | RNAseq | -0.0292 | 0.8572 | |
| SRP133303 | POLH | 5429 | RNAseq | -0.1938 | 0.0686 | |
| SRP159526 | POLH | 5429 | RNAseq | -0.1295 | 0.6665 | |
| SRP193095 | POLH | 5429 | RNAseq | -0.1624 | 0.1323 | |
| SRP219564 | POLH | 5429 | RNAseq | -0.0381 | 0.8916 | |
| TCGA | POLH | 5429 | RNAseq | 0.0114 | 0.8609 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLH | 5429 | 7 | 0 | 23 | |
| GSE20123 | POLH | 5429 | 7 | 0 | 23 | |
| GSE43470 | POLH | 5429 | 6 | 0 | 37 | |
| GSE46452 | POLH | 5429 | 2 | 9 | 48 | |
| GSE47630 | POLH | 5429 | 8 | 4 | 28 | |
| GSE54993 | POLH | 5429 | 3 | 2 | 65 | |
| GSE54994 | POLH | 5429 | 11 | 4 | 38 | |
| GSE60625 | POLH | 5429 | 0 | 1 | 10 | |
| GSE74703 | POLH | 5429 | 6 | 0 | 30 | |
| GSE74704 | POLH | 5429 | 3 | 0 | 17 | |
| TCGA | POLH | 5429 | 22 | 11 | 63 |
Total number of gains: 75; Total number of losses: 31; Total Number of normals: 382.
Somatic mutations of POLH:
Generating mutation plots.
Highly correlated genes for POLH:
Showing top 20/210 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLH | SYAP1 | 0.828776 | 3 | 0 | 3 |
| POLH | NOA1 | 0.778092 | 3 | 0 | 3 |
| POLH | FBXO10 | 0.736645 | 3 | 0 | 3 |
| POLH | ATF7 | 0.735264 | 3 | 0 | 3 |
| POLH | TSEN34 | 0.734249 | 3 | 0 | 3 |
| POLH | HOXA3 | 0.732559 | 3 | 0 | 3 |
| POLH | PPM1K | 0.721752 | 4 | 0 | 4 |
| POLH | ANKRD44 | 0.721177 | 4 | 0 | 3 |
| POLH | ARHGAP31 | 0.716344 | 3 | 0 | 3 |
| POLH | CNR1 | 0.712401 | 3 | 0 | 3 |
| POLH | FBXO32 | 0.709772 | 3 | 0 | 3 |
| POLH | ZKSCAN1 | 0.704911 | 4 | 0 | 4 |
| POLH | COL11A2 | 0.701633 | 3 | 0 | 3 |
| POLH | KALRN | 0.695544 | 3 | 0 | 3 |
| POLH | KDM2A | 0.694804 | 3 | 0 | 3 |
| POLH | EVC2 | 0.693475 | 3 | 0 | 3 |
| POLH | SEMA4D | 0.693352 | 4 | 0 | 3 |
| POLH | C3orf80 | 0.686143 | 3 | 0 | 3 |
| POLH | CXCR5 | 0.684586 | 3 | 0 | 3 |
| POLH | TNFSF15 | 0.679799 | 4 | 0 | 3 |
For details and further investigation, click here
