| Full name: ribonucleotide reductase regulatory TP53 inducible subunit M2B | Alias Symbol: p53R2 | ||
| Type: protein-coding gene | Cytoband: 8q22.3 | ||
| Entrez ID: 50484 | HGNC ID: HGNC:17296 | Ensembl Gene: ENSG00000048392 | OMIM ID: 604712 |
| Drug and gene relationship at DGIdb | |||
RRM2B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of RRM2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RRM2B | 50484 | 223342_at | 0.6375 | 0.1479 | |
| GSE26886 | RRM2B | 50484 | 223342_at | 0.1017 | 0.7749 | |
| GSE45670 | RRM2B | 50484 | 223342_at | -0.0718 | 0.7249 | |
| GSE53622 | RRM2B | 50484 | 28226 | 0.3113 | 0.0000 | |
| GSE53624 | RRM2B | 50484 | 19728 | 0.0644 | 0.4676 | |
| GSE63941 | RRM2B | 50484 | 223342_at | -1.7456 | 0.0034 | |
| GSE77861 | RRM2B | 50484 | 223342_at | 0.3612 | 0.4099 | |
| GSE97050 | RRM2B | 50484 | A_33_P3323384 | -0.0557 | 0.7983 | |
| SRP007169 | RRM2B | 50484 | RNAseq | 0.4994 | 0.2703 | |
| SRP008496 | RRM2B | 50484 | RNAseq | 0.7863 | 0.0018 | |
| SRP064894 | RRM2B | 50484 | RNAseq | 0.5536 | 0.0235 | |
| SRP133303 | RRM2B | 50484 | RNAseq | 0.0437 | 0.7433 | |
| SRP159526 | RRM2B | 50484 | RNAseq | -0.0383 | 0.9122 | |
| SRP193095 | RRM2B | 50484 | RNAseq | 0.1220 | 0.3817 | |
| SRP219564 | RRM2B | 50484 | RNAseq | 0.3143 | 0.3179 | |
| TCGA | RRM2B | 50484 | RNAseq | 0.0419 | 0.4247 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RRM2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RRM2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RRM2B | 50484 | 17 | 0 | 13 | |
| GSE20123 | RRM2B | 50484 | 18 | 0 | 12 | |
| GSE43470 | RRM2B | 50484 | 22 | 0 | 21 | |
| GSE46452 | RRM2B | 50484 | 24 | 0 | 35 | |
| GSE47630 | RRM2B | 50484 | 24 | 0 | 16 | |
| GSE54993 | RRM2B | 50484 | 0 | 20 | 50 | |
| GSE54994 | RRM2B | 50484 | 38 | 1 | 14 | |
| GSE60625 | RRM2B | 50484 | 0 | 4 | 7 | |
| GSE74703 | RRM2B | 50484 | 19 | 0 | 17 | |
| GSE74704 | RRM2B | 50484 | 12 | 0 | 8 | |
| TCGA | RRM2B | 50484 | 59 | 1 | 36 |
Total number of gains: 233; Total number of losses: 26; Total Number of normals: 229.
Somatic mutations of RRM2B:
Generating mutation plots.
Highly correlated genes for RRM2B:
Showing top 20/360 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RRM2B | DHTKD1 | 0.836649 | 3 | 0 | 3 |
| RRM2B | TRIM35 | 0.805081 | 3 | 0 | 3 |
| RRM2B | GOLPH3 | 0.779707 | 3 | 0 | 3 |
| RRM2B | ZMAT3 | 0.772108 | 3 | 0 | 3 |
| RRM2B | FGFR1OP | 0.771975 | 3 | 0 | 3 |
| RRM2B | SLC5A3 | 0.770864 | 3 | 0 | 3 |
| RRM2B | G3BP2 | 0.764635 | 3 | 0 | 3 |
| RRM2B | LYAR | 0.764253 | 3 | 0 | 3 |
| RRM2B | UBTD2 | 0.758618 | 3 | 0 | 3 |
| RRM2B | CENPE | 0.757586 | 3 | 0 | 3 |
| RRM2B | TNFRSF10B | 0.754066 | 4 | 0 | 4 |
| RRM2B | NOL10 | 0.750393 | 3 | 0 | 3 |
| RRM2B | RRAS2 | 0.749412 | 3 | 0 | 3 |
| RRM2B | NHLRC2 | 0.749202 | 3 | 0 | 3 |
| RRM2B | DPP9 | 0.740692 | 3 | 0 | 3 |
| RRM2B | NCOA6 | 0.736379 | 3 | 0 | 3 |
| RRM2B | TSC22D2 | 0.735784 | 3 | 0 | 3 |
| RRM2B | MIB1 | 0.732151 | 3 | 0 | 3 |
| RRM2B | ZCCHC14 | 0.730157 | 3 | 0 | 3 |
| RRM2B | EIF4G3 | 0.728765 | 3 | 0 | 3 |
For details and further investigation, click here
