NIPBL

 

Full name: NIPBL cohesin loading factor Alias Symbol: IDN3|DKFZp434L1319|FLJ11203|FLJ12597|FLJ13354|FLJ13648|Scc2
Type: protein-coding gene Cytoband: 5p13.2
Entrez ID: 25836 HGNC ID: HGNC:28862 Ensembl Gene: ENSG00000164190 OMIM ID: 608667
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 70/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of NIPBL:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NIPBL 25836 213918_s_at 0.4113 0.4019
GSE20347 NIPBL 25836 213918_s_at -0.1239 0.5135
GSE23400 NIPBL 25836 212469_at 0.1194 0.0050
GSE26886 NIPBL 25836 213918_s_at 0.5538 0.0337
GSE29001 NIPBL 25836 213918_s_at -0.0223 0.9434
GSE38129 NIPBL 25836 213918_s_at 0.1540 0.4365
GSE45670 NIPBL 25836 213918_s_at 0.2559 0.1735
GSE53622 NIPBL 25836 15822 0.0977 0.1473
GSE53624 NIPBL 25836 15822 0.0206 0.7395
GSE63941 NIPBL 25836 213918_s_at 0.3652 0.4540
GSE77861 NIPBL 25836 213918_s_at 0.1700 0.3989
GSE97050 NIPBL 25836 A_23_P213883 0.0200 0.9272
SRP007169 NIPBL 25836 RNAseq 0.1859 0.5628
SRP008496 NIPBL 25836 RNAseq 0.0123 0.9544
SRP064894 NIPBL 25836 RNAseq -0.3721 0.0674
SRP133303 NIPBL 25836 RNAseq 0.0532 0.6494
SRP159526 NIPBL 25836 RNAseq 0.3425 0.3379
SRP193095 NIPBL 25836 RNAseq -0.2338 0.0186
SRP219564 NIPBL 25836 RNAseq -0.3988 0.1718
TCGA NIPBL 25836 RNAseq 0.0260 0.5921

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NIPBL expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NIPBL:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NIPBL 25836 10 0 20
GSE20123 NIPBL 25836 10 0 20
GSE43470 NIPBL 25836 18 0 25
GSE46452 NIPBL 25836 5 22 32
GSE47630 NIPBL 25836 6 12 22
GSE54993 NIPBL 25836 5 4 61
GSE54994 NIPBL 25836 26 2 25
GSE60625 NIPBL 25836 0 0 11
GSE74703 NIPBL 25836 14 0 22
GSE74704 NIPBL 25836 9 0 11
TCGA NIPBL 25836 53 6 37

Total number of gains: 156; Total number of losses: 46; Total Number of normals: 286.  

 

Somatic mutations of NIPBL:

 

Generating mutation plots.

 

Highly correlated genes for NIPBL:

 

Showing top 20/241 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NIPBLTRUB20.762862303
NIPBLEPRS0.756074303
NIPBLAP1G10.755683303
NIPBLKIAA0895L0.751498303
NIPBLC11orf800.749798303
NIPBLZNF7000.739455303
NIPBLOSBPL20.736314404
NIPBLHSPA40.732957303
NIPBLRAB130.73265303
NIPBLNUDT190.727958303
NIPBLKDM2A0.727323303
NIPBLFAM49B0.724542303
NIPBLWIPI20.723088303
NIPBLOTUD6B0.718095303
NIPBLMRPS18B0.715513303
NIPBLNIP70.715107303
NIPBLNAA150.714086303
NIPBLMZT2B0.71377303
NIPBLEXOSC100.70938303
NIPBLZNF1210.707597403

For details and further investigation, click here