| Full name: 1-acylglycerol-3-phosphate O-acyltransferase 3 | Alias Symbol: LPAAT-gamma|LPAAT3 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 56894 | HGNC ID: HGNC:326 | Ensembl Gene: ENSG00000160216 | OMIM ID: 614794 |
| Drug and gene relationship at DGIdb | |||
Expression of AGPAT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGPAT3 | 56894 | 225440_at | 0.5001 | 0.5024 | |
| GSE20347 | AGPAT3 | 56894 | 219723_x_at | -0.1605 | 0.0628 | |
| GSE23400 | AGPAT3 | 56894 | 219723_x_at | -0.1939 | 0.0000 | |
| GSE26886 | AGPAT3 | 56894 | 225440_at | -0.8919 | 0.0012 | |
| GSE29001 | AGPAT3 | 56894 | 219723_x_at | -0.4238 | 0.0440 | |
| GSE38129 | AGPAT3 | 56894 | 219723_x_at | -0.1484 | 0.0920 | |
| GSE45670 | AGPAT3 | 56894 | 225440_at | -0.0393 | 0.8530 | |
| GSE53622 | AGPAT3 | 56894 | 87605 | -0.3764 | 0.0000 | |
| GSE53624 | AGPAT3 | 56894 | 87605 | -0.4273 | 0.0000 | |
| GSE63941 | AGPAT3 | 56894 | 225440_at | 0.4314 | 0.3427 | |
| GSE77861 | AGPAT3 | 56894 | 225440_at | -0.6881 | 0.0054 | |
| GSE97050 | AGPAT3 | 56894 | A_24_P344711 | -0.2467 | 0.2589 | |
| SRP007169 | AGPAT3 | 56894 | RNAseq | -1.6028 | 0.0000 | |
| SRP008496 | AGPAT3 | 56894 | RNAseq | -0.8506 | 0.0156 | |
| SRP064894 | AGPAT3 | 56894 | RNAseq | -0.4340 | 0.0001 | |
| SRP133303 | AGPAT3 | 56894 | RNAseq | -0.5927 | 0.0003 | |
| SRP159526 | AGPAT3 | 56894 | RNAseq | -0.1915 | 0.4823 | |
| SRP193095 | AGPAT3 | 56894 | RNAseq | -0.2404 | 0.0685 | |
| SRP219564 | AGPAT3 | 56894 | RNAseq | -0.4252 | 0.0470 | |
| TCGA | AGPAT3 | 56894 | RNAseq | -0.1384 | 0.0064 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AGPAT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AGPAT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGPAT3 | 56894 | 2 | 8 | 20 | |
| GSE20123 | AGPAT3 | 56894 | 2 | 8 | 20 | |
| GSE43470 | AGPAT3 | 56894 | 0 | 13 | 30 | |
| GSE46452 | AGPAT3 | 56894 | 1 | 21 | 37 | |
| GSE47630 | AGPAT3 | 56894 | 6 | 17 | 17 | |
| GSE54993 | AGPAT3 | 56894 | 8 | 1 | 61 | |
| GSE54994 | AGPAT3 | 56894 | 4 | 8 | 41 | |
| GSE60625 | AGPAT3 | 56894 | 0 | 0 | 11 | |
| GSE74703 | AGPAT3 | 56894 | 0 | 10 | 26 | |
| GSE74704 | AGPAT3 | 56894 | 1 | 4 | 15 | |
| TCGA | AGPAT3 | 56894 | 8 | 39 | 49 |
Total number of gains: 32; Total number of losses: 129; Total Number of normals: 327.
Somatic mutations of AGPAT3:
Generating mutation plots.
Highly correlated genes for AGPAT3:
Showing top 20/723 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGPAT3 | PUS10 | 0.808223 | 3 | 0 | 3 |
| AGPAT3 | PCNT | 0.776229 | 5 | 0 | 4 |
| AGPAT3 | WDR77 | 0.764763 | 3 | 0 | 3 |
| AGPAT3 | ALG6 | 0.764405 | 3 | 0 | 3 |
| AGPAT3 | AKT1S1 | 0.762951 | 3 | 0 | 3 |
| AGPAT3 | C11orf45 | 0.760642 | 3 | 0 | 3 |
| AGPAT3 | SLC35B3 | 0.749292 | 3 | 0 | 3 |
| AGPAT3 | PRADC1 | 0.748568 | 3 | 0 | 3 |
| AGPAT3 | ZNF578 | 0.744556 | 3 | 0 | 3 |
| AGPAT3 | SLC25A40 | 0.740708 | 3 | 0 | 3 |
| AGPAT3 | C2CD2 | 0.736794 | 5 | 0 | 4 |
| AGPAT3 | RAB7A | 0.733382 | 3 | 0 | 3 |
| AGPAT3 | FBXO6 | 0.732474 | 3 | 0 | 3 |
| AGPAT3 | ITPRIPL2 | 0.723831 | 3 | 0 | 3 |
| AGPAT3 | ADAM32 | 0.723277 | 3 | 0 | 3 |
| AGPAT3 | ZNF879 | 0.720384 | 4 | 0 | 4 |
| AGPAT3 | YTHDF2 | 0.716356 | 4 | 0 | 3 |
| AGPAT3 | KDM2A | 0.712754 | 3 | 0 | 3 |
| AGPAT3 | CHID1 | 0.712276 | 3 | 0 | 3 |
| AGPAT3 | CCDC167 | 0.710714 | 3 | 0 | 3 |
For details and further investigation, click here
