KDM5C

 

Full name: lysine demethylase 5C Alias Symbol: DXS1272E|XE169
Type: protein-coding gene Cytoband: Xp11.22
Entrez ID: 8242 HGNC ID: HGNC:11114 Ensembl Gene: ENSG00000126012 OMIM ID: 314690
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 24/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KDM5C:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KDM5C 8242 202383_at 0.2848 0.4463
GSE20347 KDM5C 8242 202383_at -0.0732 0.5333
GSE23400 KDM5C 8242 202383_at 0.0257 0.7172
GSE26886 KDM5C 8242 202383_at 0.0679 0.6916
GSE29001 KDM5C 8242 202383_at -0.3103 0.0844
GSE38129 KDM5C 8242 202383_at -0.0168 0.8716
GSE45670 KDM5C 8242 202383_at 0.0770 0.5111
GSE53622 KDM5C 8242 45990 -0.2183 0.0013
GSE53624 KDM5C 8242 105465 -1.8666 0.0000
GSE63941 KDM5C 8242 202383_at 0.9486 0.0042
GSE77861 KDM5C 8242 202383_at -0.0304 0.8881
GSE97050 KDM5C 8242 A_33_P3216357 -0.0476 0.8733
SRP007169 KDM5C 8242 RNAseq -0.2825 0.5070
SRP008496 KDM5C 8242 RNAseq -0.3812 0.1645
SRP064894 KDM5C 8242 RNAseq -0.2471 0.2229
SRP133303 KDM5C 8242 RNAseq 0.0890 0.7334
SRP159526 KDM5C 8242 RNAseq -0.1236 0.6377
SRP193095 KDM5C 8242 RNAseq 0.0234 0.8544
SRP219564 KDM5C 8242 RNAseq -0.2527 0.4983
TCGA KDM5C 8242 RNAseq -0.0481 0.2541

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by KDM5C expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KDM5C:

 

No record found for this gene.

 

Somatic mutations of KDM5C:

 

Generating mutation plots.

 

Highly correlated genes for KDM5C:

 

Showing top 20/497 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KDM5CRAD23A0.753196303
KDM5CATG130.752274303
KDM5CMUC5AC0.747687303
KDM5CZNF7470.738621505
KDM5CPPP1R100.726346303
KDM5CCIDEC0.72444404
KDM5CATXN3L0.723389303
KDM5CPCSK70.723091303
KDM5CFAM167B0.719787303
KDM5CGYPB0.71853303
KDM5CSIRPG0.71686303
KDM5CPLXNB10.713723303
KDM5CC10orf820.713064303
KDM5CFMO40.706204303
KDM5CMIF0.705813303
KDM5CSYN30.705748303
KDM5CTMEM2220.702511504
KDM5CPLCB20.700987403
KDM5CSAMD4B0.700771403
KDM5CGYG20.696436303

For details and further investigation, click here