| Full name: signal regulatory protein gamma | Alias Symbol: bA77C3.1|SIRP-B2|SIRPgamma|CD172g | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 55423 | HGNC ID: HGNC:15757 | Ensembl Gene: ENSG00000089012 | OMIM ID: 605466 |
| Drug and gene relationship at DGIdb | |||
SIRPG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation |
Expression of SIRPG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIRPG | 55423 | 220485_s_at | 0.6225 | 0.5087 | |
| GSE20347 | SIRPG | 55423 | 220485_s_at | 0.0551 | 0.6332 | |
| GSE23400 | SIRPG | 55423 | 220485_s_at | -0.0885 | 0.0396 | |
| GSE26886 | SIRPG | 55423 | 220485_s_at | 0.0870 | 0.6436 | |
| GSE29001 | SIRPG | 55423 | 220485_s_at | -0.0793 | 0.7037 | |
| GSE38129 | SIRPG | 55423 | 220485_s_at | 0.0189 | 0.9046 | |
| GSE45670 | SIRPG | 55423 | 220485_s_at | 0.3264 | 0.1215 | |
| GSE53622 | SIRPG | 55423 | 97705 | 0.3244 | 0.0038 | |
| GSE53624 | SIRPG | 55423 | 97705 | 0.0596 | 0.5768 | |
| GSE63941 | SIRPG | 55423 | 234742_at | 0.1389 | 0.3406 | |
| GSE77861 | SIRPG | 55423 | 220485_s_at | -0.2361 | 0.1529 | |
| GSE97050 | SIRPG | 55423 | A_33_P3343872 | 0.8975 | 0.0832 | |
| SRP133303 | SIRPG | 55423 | RNAseq | 0.3108 | 0.4579 | |
| SRP159526 | SIRPG | 55423 | RNAseq | -0.6942 | 0.4883 | |
| SRP219564 | SIRPG | 55423 | RNAseq | 1.7325 | 0.0187 | |
| TCGA | SIRPG | 55423 | RNAseq | 0.7106 | 0.0261 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SIRPG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIRPG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIRPG | 55423 | 13 | 3 | 14 | |
| GSE20123 | SIRPG | 55423 | 14 | 3 | 13 | |
| GSE43470 | SIRPG | 55423 | 11 | 1 | 31 | |
| GSE46452 | SIRPG | 55423 | 26 | 1 | 32 | |
| GSE47630 | SIRPG | 55423 | 18 | 4 | 18 | |
| GSE54993 | SIRPG | 55423 | 2 | 14 | 54 | |
| GSE54994 | SIRPG | 55423 | 24 | 2 | 27 | |
| GSE60625 | SIRPG | 55423 | 0 | 0 | 11 | |
| GSE74703 | SIRPG | 55423 | 10 | 1 | 25 | |
| GSE74704 | SIRPG | 55423 | 9 | 1 | 10 | |
| TCGA | SIRPG | 55423 | 40 | 11 | 45 |
Total number of gains: 167; Total number of losses: 41; Total Number of normals: 280.
Somatic mutations of SIRPG:
Generating mutation plots.
Highly correlated genes for SIRPG:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIRPG | ZSWIM1 | 0.727977 | 3 | 0 | 3 |
| SIRPG | GEMIN7 | 0.721631 | 3 | 0 | 3 |
| SIRPG | CSF2 | 0.719291 | 3 | 0 | 3 |
| SIRPG | SAMD15 | 0.719124 | 3 | 0 | 3 |
| SIRPG | KDM5C | 0.71686 | 3 | 0 | 3 |
| SIRPG | ZNF771 | 0.711852 | 3 | 0 | 3 |
| SIRPG | VAC14 | 0.701009 | 3 | 0 | 3 |
| SIRPG | PATL2 | 0.697713 | 3 | 0 | 3 |
| SIRPG | TNFSF8 | 0.692279 | 6 | 0 | 6 |
| SIRPG | SNX20 | 0.69138 | 5 | 0 | 4 |
| SIRPG | CD53 | 0.684666 | 6 | 0 | 5 |
| SIRPG | CXXC1 | 0.681819 | 4 | 0 | 3 |
| SIRPG | CD3E | 0.680818 | 11 | 0 | 11 |
| SIRPG | SCN10A | 0.679766 | 4 | 0 | 4 |
| SIRPG | PTPRC | 0.679664 | 6 | 0 | 5 |
| SIRPG | BMP15 | 0.678849 | 3 | 0 | 3 |
| SIRPG | B3GNT4 | 0.678687 | 3 | 0 | 3 |
| SIRPG | XKR8 | 0.678532 | 4 | 0 | 3 |
| SIRPG | CXCL13 | 0.678218 | 8 | 0 | 8 |
| SIRPG | PIK3R5 | 0.677384 | 6 | 0 | 5 |
For details and further investigation, click here
