| Full name: proprotein convertase subtilisin/kexin type 7 | Alias Symbol: PC7|PC8|LPC|SPC7 | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 9159 | HGNC ID: HGNC:8748 | Ensembl Gene: ENSG00000160613 | OMIM ID: 604872 |
| Drug and gene relationship at DGIdb | |||
Expression of PCSK7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCSK7 | 9159 | 203118_at | 0.0161 | 0.9772 | |
| GSE20347 | PCSK7 | 9159 | 203118_at | -0.4240 | 0.0000 | |
| GSE23400 | PCSK7 | 9159 | 203118_at | -0.2429 | 0.0000 | |
| GSE26886 | PCSK7 | 9159 | 203118_at | -0.8423 | 0.0001 | |
| GSE29001 | PCSK7 | 9159 | 203118_at | -0.3705 | 0.0316 | |
| GSE38129 | PCSK7 | 9159 | 203118_at | -0.4302 | 0.0000 | |
| GSE45670 | PCSK7 | 9159 | 203118_at | 0.1619 | 0.2261 | |
| GSE63941 | PCSK7 | 9159 | 203118_at | -0.1945 | 0.5803 | |
| GSE77861 | PCSK7 | 9159 | 203118_at | -0.2037 | 0.3411 | |
| GSE97050 | PCSK7 | 9159 | A_32_P66974 | -1.0645 | 0.1555 | |
| SRP007169 | PCSK7 | 9159 | RNAseq | -1.8355 | 0.0001 | |
| SRP008496 | PCSK7 | 9159 | RNAseq | -1.5337 | 0.0000 | |
| SRP064894 | PCSK7 | 9159 | RNAseq | -0.2793 | 0.1844 | |
| SRP133303 | PCSK7 | 9159 | RNAseq | -0.5933 | 0.0000 | |
| SRP159526 | PCSK7 | 9159 | RNAseq | -0.6991 | 0.0012 | |
| SRP193095 | PCSK7 | 9159 | RNAseq | -0.6888 | 0.0042 | |
| SRP219564 | PCSK7 | 9159 | RNAseq | -0.5699 | 0.0525 | |
| TCGA | PCSK7 | 9159 | RNAseq | -0.2736 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PCSK7 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PCSK7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCSK7 | 9159 | 1 | 13 | 16 | |
| GSE20123 | PCSK7 | 9159 | 1 | 13 | 16 | |
| GSE43470 | PCSK7 | 9159 | 2 | 8 | 33 | |
| GSE46452 | PCSK7 | 9159 | 3 | 26 | 30 | |
| GSE47630 | PCSK7 | 9159 | 2 | 19 | 19 | |
| GSE54993 | PCSK7 | 9159 | 10 | 0 | 60 | |
| GSE54994 | PCSK7 | 9159 | 5 | 19 | 29 | |
| GSE60625 | PCSK7 | 9159 | 0 | 3 | 8 | |
| GSE74703 | PCSK7 | 9159 | 1 | 5 | 30 | |
| GSE74704 | PCSK7 | 9159 | 0 | 9 | 11 | |
| TCGA | PCSK7 | 9159 | 5 | 50 | 41 |
Total number of gains: 30; Total number of losses: 165; Total Number of normals: 293.
Somatic mutations of PCSK7:
Generating mutation plots.
Highly correlated genes for PCSK7:
Showing top 20/718 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCSK7 | KDM5C | 0.723091 | 3 | 0 | 3 |
| PCSK7 | CAPN1 | 0.709968 | 8 | 0 | 7 |
| PCSK7 | SOWAHC | 0.709319 | 3 | 0 | 3 |
| PCSK7 | TRAPPC8 | 0.696474 | 3 | 0 | 3 |
| PCSK7 | RAB14 | 0.691945 | 3 | 0 | 3 |
| PCSK7 | CTDSPL | 0.689874 | 4 | 0 | 4 |
| PCSK7 | C1orf21 | 0.688773 | 4 | 0 | 3 |
| PCSK7 | VPS26B | 0.681441 | 4 | 0 | 3 |
| PCSK7 | NDST1 | 0.679756 | 8 | 0 | 7 |
| PCSK7 | ITGB3 | 0.677736 | 4 | 0 | 4 |
| PCSK7 | PARP4 | 0.674736 | 4 | 0 | 4 |
| PCSK7 | HOPX | 0.671049 | 6 | 0 | 6 |
| PCSK7 | KAZN | 0.668323 | 6 | 0 | 6 |
| PCSK7 | GAS6 | 0.667003 | 4 | 0 | 3 |
| PCSK7 | RARG | 0.665111 | 7 | 0 | 6 |
| PCSK7 | RAF1 | 0.664174 | 4 | 0 | 4 |
| PCSK7 | SCAMP2 | 0.663199 | 7 | 0 | 7 |
| PCSK7 | IFRD2 | 0.662551 | 3 | 0 | 3 |
| PCSK7 | ARHGAP32 | 0.659404 | 7 | 0 | 7 |
| PCSK7 | SH3GLB1 | 0.656152 | 6 | 0 | 5 |
For details and further investigation, click here
