ULK1

 

Full name: unc-51 like autophagy activating kinase 1 Alias Symbol: ATG1|ATG1A
Type: protein-coding gene Cytoband: 12q24.33
Entrez ID: 8408 HGNC ID: HGNC:12558 Ensembl Gene: ENSG00000177169 OMIM ID: 603168
Drug and gene relationship at DGIdb

 

ULK1 involved pathways:

KEGG pathway Description View
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal

 

Expression of ULK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ULK1 8408 209333_at 0.4213 0.3586
GSE20347 ULK1 8408 209333_at 0.4297 0.0037
GSE23400 ULK1 8408 209333_at 0.1979 0.0025
GSE26886 ULK1 8408 209333_at 0.3805 0.1714
GSE29001 ULK1 8408 209333_at 0.2830 0.2072
GSE38129 ULK1 8408 209333_at 0.3202 0.0068
GSE45670 ULK1 8408 209333_at 0.2582 0.1242
GSE53622 ULK1 8408 27954 0.1516 0.1081
GSE53624 ULK1 8408 27954 0.3224 0.0000
GSE63941 ULK1 8408 209333_at 0.0022 0.9974
GSE77861 ULK1 8408 209333_at 0.6763 0.0210
GSE97050 ULK1 8408 A_24_P73370 -0.2048 0.5246
SRP007169 ULK1 8408 RNAseq -0.2928 0.5571
SRP008496 ULK1 8408 RNAseq -0.0952 0.7718
SRP064894 ULK1 8408 RNAseq 0.1834 0.3055
SRP133303 ULK1 8408 RNAseq 0.2465 0.2212
SRP159526 ULK1 8408 RNAseq 0.6776 0.0273
SRP193095 ULK1 8408 RNAseq 0.4613 0.0180
SRP219564 ULK1 8408 RNAseq -0.3025 0.4392
TCGA ULK1 8408 RNAseq -0.0541 0.3420

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ULK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ULK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ULK1 8408 4 5 21
GSE20123 ULK1 8408 4 5 21
GSE43470 ULK1 8408 3 3 37
GSE46452 ULK1 8408 8 3 48
GSE47630 ULK1 8408 9 3 28
GSE54993 ULK1 8408 0 6 64
GSE54994 ULK1 8408 4 8 41
GSE60625 ULK1 8408 0 0 11
GSE74703 ULK1 8408 2 3 31
GSE74704 ULK1 8408 2 3 15
TCGA ULK1 8408 22 14 60

Total number of gains: 58; Total number of losses: 53; Total Number of normals: 377.  

 

Somatic mutations of ULK1:

 

Generating mutation plots.

 

Highly correlated genes for ULK1:

 

Showing top 20/406 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ULK1USF20.810791303
ULK1SIPA1L20.798417303
ULK1IFT1400.789961303
ULK1GALNT20.775125303
ULK1ZNF518B0.771591303
ULK1NAF10.770172303
ULK1KDM6B0.769023303
ULK1SSBP40.760572404
ULK1TG0.759423303
ULK1SESTD10.753875303
ULK1HELZ0.753629403
ULK1SURF60.749276303
ULK1KIAA05130.745858303
ULK1C1orf1980.744734404
ULK1RLIM0.734912303
ULK1PRICKLE10.734892303
ULK1IRF2BP20.73088303
ULK1GATAD2B0.729984404
ULK1CDKN1C0.729198303
ULK1RIOK10.725129303

For details and further investigation, click here