| Full name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | Alias Symbol: cblE | ||
| Type: protein-coding gene | Cytoband: 5p15.31 | ||
| Entrez ID: 4552 | HGNC ID: HGNC:7473 | Ensembl Gene: ENSG00000124275 | OMIM ID: 602568 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MTRR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTRR | 4552 | 203200_s_at | 0.4903 | 0.0736 | |
| GSE20347 | MTRR | 4552 | 203200_s_at | 0.4360 | 0.0234 | |
| GSE23400 | MTRR | 4552 | 203200_s_at | 0.4962 | 0.0000 | |
| GSE26886 | MTRR | 4552 | 203200_s_at | 1.1593 | 0.0000 | |
| GSE29001 | MTRR | 4552 | 203200_s_at | 0.4195 | 0.0815 | |
| GSE38129 | MTRR | 4552 | 203200_s_at | 0.3189 | 0.0343 | |
| GSE45670 | MTRR | 4552 | 203200_s_at | 0.2411 | 0.3468 | |
| GSE53622 | MTRR | 4552 | 25473 | 0.4415 | 0.0000 | |
| GSE53624 | MTRR | 4552 | 28341 | 0.5558 | 0.0000 | |
| GSE63941 | MTRR | 4552 | 203200_s_at | 0.3662 | 0.4095 | |
| GSE77861 | MTRR | 4552 | 203200_s_at | 0.7247 | 0.1314 | |
| GSE97050 | MTRR | 4552 | A_23_P252211 | 0.5124 | 0.1581 | |
| SRP007169 | MTRR | 4552 | RNAseq | 0.5145 | 0.1521 | |
| SRP008496 | MTRR | 4552 | RNAseq | 0.5628 | 0.0630 | |
| SRP064894 | MTRR | 4552 | RNAseq | 0.1099 | 0.5688 | |
| SRP133303 | MTRR | 4552 | RNAseq | 0.4960 | 0.0036 | |
| SRP159526 | MTRR | 4552 | RNAseq | 0.3726 | 0.0364 | |
| SRP193095 | MTRR | 4552 | RNAseq | 0.3722 | 0.0017 | |
| SRP219564 | MTRR | 4552 | RNAseq | 0.3991 | 0.2454 | |
| TCGA | MTRR | 4552 | RNAseq | 0.0762 | 0.1650 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MTRR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTRR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTRR | 4552 | 12 | 0 | 18 | |
| GSE20123 | MTRR | 4552 | 12 | 0 | 18 | |
| GSE43470 | MTRR | 4552 | 16 | 0 | 27 | |
| GSE46452 | MTRR | 4552 | 6 | 22 | 31 | |
| GSE47630 | MTRR | 4552 | 6 | 11 | 23 | |
| GSE54993 | MTRR | 4552 | 5 | 5 | 60 | |
| GSE54994 | MTRR | 4552 | 29 | 1 | 23 | |
| GSE60625 | MTRR | 4552 | 0 | 0 | 11 | |
| GSE74703 | MTRR | 4552 | 12 | 0 | 24 | |
| GSE74704 | MTRR | 4552 | 11 | 0 | 9 | |
| TCGA | MTRR | 4552 | 57 | 4 | 35 |
Total number of gains: 166; Total number of losses: 43; Total Number of normals: 279.
Somatic mutations of MTRR:
Generating mutation plots.
Highly correlated genes for MTRR:
Showing top 20/1130 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTRR | UXS1 | 0.804033 | 3 | 0 | 3 |
| MTRR | RBM12B | 0.781563 | 3 | 0 | 3 |
| MTRR | KDM6B | 0.766078 | 3 | 0 | 3 |
| MTRR | PGM2L1 | 0.759624 | 4 | 0 | 4 |
| MTRR | IFIH1 | 0.759348 | 3 | 0 | 3 |
| MTRR | CHD8 | 0.748124 | 3 | 0 | 3 |
| MTRR | GEMIN5 | 0.744809 | 3 | 0 | 3 |
| MTRR | TMEM132A | 0.743254 | 4 | 0 | 4 |
| MTRR | ZC3H3 | 0.74263 | 3 | 0 | 3 |
| MTRR | CISD2 | 0.739417 | 3 | 0 | 3 |
| MTRR | PDP1 | 0.738557 | 3 | 0 | 3 |
| MTRR | TMEM237 | 0.737413 | 3 | 0 | 3 |
| MTRR | PAQR3 | 0.735672 | 3 | 0 | 3 |
| MTRR | BIRC2 | 0.73444 | 4 | 0 | 3 |
| MTRR | NTPCR | 0.734236 | 3 | 0 | 3 |
| MTRR | DHX37 | 0.732662 | 4 | 0 | 4 |
| MTRR | CIC | 0.728921 | 3 | 0 | 3 |
| MTRR | CDCA2 | 0.723936 | 4 | 0 | 4 |
| MTRR | SSBP4 | 0.721687 | 3 | 0 | 3 |
| MTRR | TMEM44 | 0.717688 | 3 | 0 | 3 |
For details and further investigation, click here
