WDR75

 

Full name: WD repeat domain 75 Alias Symbol: FLJ12519|NET16|UTP17
Type: protein-coding gene Cytoband: 2q32.2
Entrez ID: 84128 HGNC ID: HGNC:25725 Ensembl Gene: ENSG00000115368 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of WDR75:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WDR75 84128 224721_at 0.8290 0.1411
GSE26886 WDR75 84128 224721_at 0.6924 0.0004
GSE45670 WDR75 84128 224721_at 0.4162 0.0095
GSE53622 WDR75 84128 60481 0.5396 0.0000
GSE53624 WDR75 84128 60481 0.7855 0.0000
GSE63941 WDR75 84128 224721_at 0.8021 0.0711
GSE77861 WDR75 84128 224721_at 0.6563 0.0142
GSE97050 WDR75 84128 A_32_P217510 0.1457 0.5259
SRP007169 WDR75 84128 RNAseq 1.7640 0.0004
SRP008496 WDR75 84128 RNAseq 1.8776 0.0000
SRP064894 WDR75 84128 RNAseq 0.4326 0.0039
SRP133303 WDR75 84128 RNAseq 0.4900 0.0043
SRP159526 WDR75 84128 RNAseq 0.2826 0.0936
SRP193095 WDR75 84128 RNAseq 0.3502 0.0040
SRP219564 WDR75 84128 RNAseq 0.1436 0.5587
TCGA WDR75 84128 RNAseq 0.1903 0.0001

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by WDR75 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WDR75:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WDR75 84128 9 2 19
GSE20123 WDR75 84128 9 2 19
GSE43470 WDR75 84128 3 1 39
GSE46452 WDR75 84128 1 4 54
GSE47630 WDR75 84128 4 5 31
GSE54993 WDR75 84128 0 5 65
GSE54994 WDR75 84128 12 6 35
GSE60625 WDR75 84128 0 3 8
GSE74703 WDR75 84128 2 1 33
GSE74704 WDR75 84128 3 2 15
TCGA WDR75 84128 24 6 66

Total number of gains: 67; Total number of losses: 37; Total Number of normals: 384.  

 

Somatic mutations of WDR75:

 

Generating mutation plots.

 

Highly correlated genes for WDR75:

 

Showing top 20/1474 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WDR75CBFA2T20.849048303
WDR75NOSIP0.815079303
WDR75NSMAF0.793591303
WDR75TMEM1350.792354303
WDR75PTOV10.784646303
WDR75KDM6B0.777593303
WDR75UXS10.775253403
WDR75C9orf640.772056303
WDR75DDX100.768139403
WDR75CMTM40.766677403
WDR75SLC35E10.765585303
WDR75CELF10.761928404
WDR75ATM0.760643303
WDR75PRPS10.760261404
WDR75FZD60.758325403
WDR75EXOC60.756303
WDR75ZCCHC70.755126303
WDR75TNPO10.754231505
WDR75TPP20.751194303
WDR75NIPA20.740706404

For details and further investigation, click here