| Full name: insulin like growth factor 2 receptor | Alias Symbol: CD222|MPRI|MPR1|CIMPR|M6P-R|CI-M6PR|CI-MPR|MPR300 | ||
| Type: protein-coding gene | Cytoband: 6q25.3 | ||
| Entrez ID: 3482 | HGNC ID: HGNC:5467 | Ensembl Gene: ENSG00000197081 | OMIM ID: 147280 |
| Drug and gene relationship at DGIdb | |||
Expression of IGF2R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGF2R | 3482 | 201393_s_at | 0.9106 | 0.0265 | |
| GSE20347 | IGF2R | 3482 | 201393_s_at | 0.2455 | 0.2059 | |
| GSE23400 | IGF2R | 3482 | 201393_s_at | 0.5908 | 0.0000 | |
| GSE26886 | IGF2R | 3482 | 201393_s_at | 0.1773 | 0.6418 | |
| GSE29001 | IGF2R | 3482 | 201393_s_at | 0.2979 | 0.3196 | |
| GSE38129 | IGF2R | 3482 | 201393_s_at | 0.4602 | 0.0031 | |
| GSE45670 | IGF2R | 3482 | 201393_s_at | 0.5181 | 0.0002 | |
| GSE53622 | IGF2R | 3482 | 962 | 0.2441 | 0.0065 | |
| GSE53624 | IGF2R | 3482 | 962 | 0.3876 | 0.0000 | |
| GSE63941 | IGF2R | 3482 | 201393_s_at | -1.5397 | 0.0101 | |
| GSE77861 | IGF2R | 3482 | 201393_s_at | 0.6613 | 0.0102 | |
| GSE97050 | IGF2R | 3482 | A_23_P334021 | 0.0827 | 0.6669 | |
| SRP007169 | IGF2R | 3482 | RNAseq | 1.8591 | 0.0000 | |
| SRP008496 | IGF2R | 3482 | RNAseq | 1.7938 | 0.0000 | |
| SRP064894 | IGF2R | 3482 | RNAseq | 0.7708 | 0.0051 | |
| SRP133303 | IGF2R | 3482 | RNAseq | 0.4927 | 0.0008 | |
| SRP159526 | IGF2R | 3482 | RNAseq | 0.3045 | 0.3227 | |
| SRP193095 | IGF2R | 3482 | RNAseq | 0.5191 | 0.0003 | |
| SRP219564 | IGF2R | 3482 | RNAseq | 0.1530 | 0.7074 | |
| TCGA | IGF2R | 3482 | RNAseq | -0.0056 | 0.9023 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by IGF2R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGF2R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGF2R | 3482 | 1 | 5 | 24 | |
| GSE20123 | IGF2R | 3482 | 1 | 4 | 25 | |
| GSE43470 | IGF2R | 3482 | 4 | 0 | 39 | |
| GSE46452 | IGF2R | 3482 | 3 | 10 | 46 | |
| GSE47630 | IGF2R | 3482 | 9 | 4 | 27 | |
| GSE54993 | IGF2R | 3482 | 4 | 4 | 62 | |
| GSE54994 | IGF2R | 3482 | 8 | 9 | 36 | |
| GSE60625 | IGF2R | 3482 | 0 | 1 | 10 | |
| GSE74703 | IGF2R | 3482 | 4 | 0 | 32 | |
| GSE74704 | IGF2R | 3482 | 0 | 2 | 18 | |
| TCGA | IGF2R | 3482 | 13 | 22 | 61 |
Total number of gains: 47; Total number of losses: 61; Total Number of normals: 380.
Somatic mutations of IGF2R:
Generating mutation plots.
Highly correlated genes for IGF2R:
Showing top 20/1155 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGF2R | ARFRP1 | 0.817078 | 3 | 0 | 3 |
| IGF2R | NTPCR | 0.799529 | 4 | 0 | 4 |
| IGF2R | USP36 | 0.796735 | 3 | 0 | 3 |
| IGF2R | RPL7L1 | 0.791658 | 3 | 0 | 3 |
| IGF2R | SLC39A3 | 0.790968 | 3 | 0 | 3 |
| IGF2R | TMTC4 | 0.786506 | 3 | 0 | 3 |
| IGF2R | PGM2L1 | 0.779933 | 3 | 0 | 3 |
| IGF2R | C20orf194 | 0.776858 | 3 | 0 | 3 |
| IGF2R | SSBP4 | 0.774756 | 4 | 0 | 4 |
| IGF2R | CCDC102B | 0.772849 | 3 | 0 | 3 |
| IGF2R | VANGL2 | 0.767015 | 4 | 0 | 4 |
| IGF2R | RBM15B | 0.762488 | 3 | 0 | 3 |
| IGF2R | KDM6B | 0.76246 | 3 | 0 | 3 |
| IGF2R | TEAD2 | 0.760588 | 3 | 0 | 3 |
| IGF2R | FAM89B | 0.751855 | 4 | 0 | 4 |
| IGF2R | TSEN15 | 0.750048 | 4 | 0 | 4 |
| IGF2R | HELZ | 0.748435 | 4 | 0 | 3 |
| IGF2R | TCF7L1 | 0.748219 | 3 | 0 | 3 |
| IGF2R | MRPS9 | 0.743746 | 3 | 0 | 3 |
| IGF2R | RFTN1 | 0.736133 | 3 | 0 | 3 |
For details and further investigation, click here
