TFRC

 

Full name: transferrin receptor Alias Symbol: CD71|TFR1|p90
Type: protein-coding gene Cytoband: 3q29
Entrez ID: 7037 HGNC ID: HGNC:11763 Ensembl Gene: ENSG00000072274 OMIM ID: 190010
Drug and gene relationship at DGIdb
Screen Evidence:

 

TFRC involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway

 

Expression of TFRC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TFRC 7037 208691_at 1.4828 0.0209
GSE20347 TFRC 7037 208691_at 1.8785 0.0000
GSE23400 TFRC 7037 208691_at 1.4372 0.0000
GSE26886 TFRC 7037 208691_at 0.7887 0.0046
GSE29001 TFRC 7037 208691_at 1.0082 0.0003
GSE38129 TFRC 7037 208691_at 2.0088 0.0000
GSE45670 TFRC 7037 208691_at 1.5182 0.0000
GSE53622 TFRC 7037 75023 1.8291 0.0000
GSE53624 TFRC 7037 75023 1.8655 0.0000
GSE63941 TFRC 7037 208691_at 0.0724 0.8827
GSE77861 TFRC 7037 208691_at 1.4671 0.0107
GSE97050 TFRC 7037 A_23_P212617 0.8762 0.0620
SRP007169 TFRC 7037 RNAseq 3.0511 0.0000
SRP008496 TFRC 7037 RNAseq 2.7403 0.0000
SRP064894 TFRC 7037 RNAseq 1.5467 0.0000
SRP133303 TFRC 7037 RNAseq 1.9746 0.0000
SRP159526 TFRC 7037 RNAseq 3.0560 0.0000
SRP193095 TFRC 7037 RNAseq 1.2625 0.0000
SRP219564 TFRC 7037 RNAseq 0.8760 0.0283
TCGA TFRC 7037 RNAseq 0.5132 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by TFRC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TFRC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TFRC 7037 22 0 8
GSE20123 TFRC 7037 22 0 8
GSE43470 TFRC 7037 21 0 22
GSE46452 TFRC 7037 19 1 39
GSE47630 TFRC 7037 27 2 11
GSE54993 TFRC 7037 1 22 47
GSE54994 TFRC 7037 41 0 12
GSE60625 TFRC 7037 0 6 5
GSE74703 TFRC 7037 19 0 17
GSE74704 TFRC 7037 14 0 6
TCGA TFRC 7037 77 0 19

Total number of gains: 263; Total number of losses: 31; Total Number of normals: 194.  

 

Somatic mutations of TFRC:

 

Generating mutation plots.

 

Highly correlated genes for TFRC:

 

Showing top 20/2070 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TFRCECT20.8009111010
TFRCU2SURP0.784233909
TFRCFAM89A0.784171303
TFRCTMEM1380.780242606
TFRCACTL6A0.77862212012
TFRCRFC40.77748212011
TFRCFLVCR10.773908606
TFRCGMPS0.77341712012
TFRCLAPTM4B0.7711912012
TFRCFOXM10.76920310010
TFRCMCM60.7677612012
TFRCMCM20.76600611011
TFRCCKS20.76459511011
TFRCCCNB20.76344811011
TFRCPTDSS10.7628311011
TFRCMMS22L0.760934303
TFRCKDM6B0.758615303
TFRCDNAJC20.75705911011
TFRCMTHFD20.75624712011
TFRCTMEM132A0.755092808

For details and further investigation, click here