| Full name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 | Alias Symbol: cl-6|nkat2|nkat2a|nkat2b|p58|CD158B2 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 3804 | HGNC ID: HGNC:6331 | Ensembl Gene: ENSG00000243772 | OMIM ID: 604938 |
| Drug and gene relationship at DGIdb | |||
KIR2DL3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of KIR2DL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIR2DL3 | 3804 | 208179_x_at | 0.1129 | 0.5922 | |
| GSE20347 | KIR2DL3 | 3804 | 208179_x_at | 0.0735 | 0.5065 | |
| GSE23400 | KIR2DL3 | 3804 | 208179_x_at | -0.1205 | 0.0005 | |
| GSE26886 | KIR2DL3 | 3804 | 208179_x_at | 0.1223 | 0.2760 | |
| GSE29001 | KIR2DL3 | 3804 | 208179_x_at | -0.0322 | 0.8208 | |
| GSE38129 | KIR2DL3 | 3804 | 208179_x_at | -0.0890 | 0.2386 | |
| GSE45670 | KIR2DL3 | 3804 | 208179_x_at | 0.1294 | 0.1083 | |
| GSE53622 | KIR2DL3 | 3804 | 135614 | 0.4534 | 0.0029 | |
| GSE53624 | KIR2DL3 | 3804 | 135614 | 0.3690 | 0.0001 | |
| GSE63941 | KIR2DL3 | 3804 | 208179_x_at | 0.0247 | 0.8924 | |
| GSE77861 | KIR2DL3 | 3804 | 208179_x_at | 0.1297 | 0.2760 | |
| TCGA | KIR2DL3 | 3804 | RNAseq | 2.3128 | 0.1213 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KIR2DL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIR2DL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIR2DL3 | 3804 | 3 | 4 | 23 | |
| GSE20123 | KIR2DL3 | 3804 | 3 | 3 | 24 | |
| GSE43470 | KIR2DL3 | 3804 | 3 | 11 | 29 | |
| GSE46452 | KIR2DL3 | 3804 | 45 | 1 | 13 | |
| GSE47630 | KIR2DL3 | 3804 | 8 | 6 | 26 | |
| GSE54993 | KIR2DL3 | 3804 | 17 | 4 | 49 | |
| GSE54994 | KIR2DL3 | 3804 | 4 | 13 | 36 | |
| GSE60625 | KIR2DL3 | 3804 | 9 | 0 | 2 | |
| GSE74703 | KIR2DL3 | 3804 | 3 | 7 | 26 | |
| GSE74704 | KIR2DL3 | 3804 | 3 | 1 | 16 | |
| TCGA | KIR2DL3 | 3804 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of KIR2DL3:
Generating mutation plots.
Highly correlated genes for KIR2DL3:
Showing top 20/524 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIR2DL3 | RCVRN | 0.700928 | 5 | 0 | 5 |
| KIR2DL3 | CA7 | 0.700319 | 4 | 0 | 4 |
| KIR2DL3 | THEG | 0.670324 | 4 | 0 | 4 |
| KIR2DL3 | KHDRBS2 | 0.666699 | 4 | 0 | 4 |
| KIR2DL3 | HRC | 0.664755 | 3 | 0 | 3 |
| KIR2DL3 | SCN8A | 0.662749 | 3 | 0 | 3 |
| KIR2DL3 | CEACAM21 | 0.661974 | 5 | 0 | 5 |
| KIR2DL3 | CETP | 0.65825 | 3 | 0 | 3 |
| KIR2DL3 | CNTD2 | 0.656173 | 7 | 0 | 6 |
| KIR2DL3 | SIGLEC6 | 0.647904 | 4 | 0 | 4 |
| KIR2DL3 | JAK3 | 0.645447 | 5 | 0 | 5 |
| KIR2DL3 | RBM12B-AS1 | 0.645087 | 4 | 0 | 4 |
| KIR2DL3 | NRGN | 0.645067 | 3 | 0 | 3 |
| KIR2DL3 | EDA2R | 0.644888 | 5 | 0 | 5 |
| KIR2DL3 | MYH8 | 0.64247 | 3 | 0 | 3 |
| KIR2DL3 | OR10H3 | 0.63921 | 4 | 0 | 4 |
| KIR2DL3 | CRISP1 | 0.637304 | 3 | 0 | 3 |
| KIR2DL3 | MAS1 | 0.634854 | 5 | 0 | 5 |
| KIR2DL3 | CYSLTR2 | 0.631187 | 5 | 0 | 5 |
| KIR2DL3 | FBXL18 | 0.630972 | 5 | 0 | 4 |
For details and further investigation, click here
