| Full name: sodium voltage-gated channel alpha subunit 8 | Alias Symbol: Nav1.6|NaCh6|PN4|CerIII|CIAT | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 6334 | HGNC ID: HGNC:10596 | Ensembl Gene: ENSG00000196876 | OMIM ID: 600702 |
| Drug and gene relationship at DGIdb | |||
Expression of SCN8A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN8A | 6334 | 236329_at | 0.1039 | 0.8438 | |
| GSE20347 | SCN8A | 6334 | 207049_at | 0.0655 | 0.5123 | |
| GSE23400 | SCN8A | 6334 | 207049_at | -0.1435 | 0.0001 | |
| GSE26886 | SCN8A | 6334 | 236329_at | 0.0343 | 0.7580 | |
| GSE29001 | SCN8A | 6334 | 207049_at | 0.0457 | 0.8362 | |
| GSE38129 | SCN8A | 6334 | 207049_at | 0.0457 | 0.5997 | |
| GSE45670 | SCN8A | 6334 | 236329_at | 0.2062 | 0.1129 | |
| GSE53622 | SCN8A | 6334 | 38943 | -0.3210 | 0.0581 | |
| GSE53624 | SCN8A | 6334 | 38943 | -1.7864 | 0.0000 | |
| GSE63941 | SCN8A | 6334 | 236329_at | 0.1127 | 0.6950 | |
| GSE77861 | SCN8A | 6334 | 236329_at | -0.0971 | 0.3802 | |
| GSE97050 | SCN8A | 6334 | A_23_P76245 | 0.7339 | 0.2217 | |
| SRP007169 | SCN8A | 6334 | RNAseq | 3.9274 | 0.0016 | |
| SRP064894 | SCN8A | 6334 | RNAseq | 1.8551 | 0.0000 | |
| SRP133303 | SCN8A | 6334 | RNAseq | 1.3476 | 0.0000 | |
| SRP159526 | SCN8A | 6334 | RNAseq | 1.4576 | 0.0007 | |
| SRP193095 | SCN8A | 6334 | RNAseq | 1.1839 | 0.0000 | |
| SRP219564 | SCN8A | 6334 | RNAseq | 1.6818 | 0.0011 | |
| TCGA | SCN8A | 6334 | RNAseq | 0.5916 | 0.0187 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by SCN8A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN8A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN8A | 6334 | 8 | 1 | 21 | |
| GSE20123 | SCN8A | 6334 | 8 | 1 | 21 | |
| GSE43470 | SCN8A | 6334 | 4 | 0 | 39 | |
| GSE46452 | SCN8A | 6334 | 8 | 1 | 50 | |
| GSE47630 | SCN8A | 6334 | 11 | 2 | 27 | |
| GSE54993 | SCN8A | 6334 | 0 | 5 | 65 | |
| GSE54994 | SCN8A | 6334 | 3 | 5 | 45 | |
| GSE60625 | SCN8A | 6334 | 0 | 0 | 11 | |
| GSE74703 | SCN8A | 6334 | 3 | 0 | 33 | |
| GSE74704 | SCN8A | 6334 | 5 | 1 | 14 | |
| TCGA | SCN8A | 6334 | 13 | 11 | 72 |
Total number of gains: 63; Total number of losses: 27; Total Number of normals: 398.
Somatic mutations of SCN8A:
Generating mutation plots.
Highly correlated genes for SCN8A:
Showing top 20/412 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN8A | GDAP1 | 0.725642 | 3 | 0 | 3 |
| SCN8A | UBXN2A | 0.706723 | 3 | 0 | 3 |
| SCN8A | MED24 | 0.694915 | 6 | 0 | 6 |
| SCN8A | PPP2R2C | 0.682619 | 3 | 0 | 3 |
| SCN8A | CAMK2B | 0.681548 | 4 | 0 | 3 |
| SCN8A | OR10H3 | 0.67605 | 5 | 0 | 5 |
| SCN8A | TAL1 | 0.674168 | 5 | 0 | 5 |
| SCN8A | CCDC30 | 0.671525 | 5 | 0 | 5 |
| SCN8A | LOR | 0.670872 | 3 | 0 | 3 |
| SCN8A | DOT1L | 0.668716 | 4 | 0 | 4 |
| SCN8A | ERN2 | 0.666135 | 5 | 0 | 5 |
| SCN8A | KIR2DL3 | 0.662749 | 3 | 0 | 3 |
| SCN8A | IL17A | 0.654955 | 4 | 0 | 4 |
| SCN8A | CYP3A4 | 0.653345 | 5 | 0 | 4 |
| SCN8A | PRLR | 0.651518 | 5 | 0 | 4 |
| SCN8A | RET | 0.65144 | 3 | 0 | 3 |
| SCN8A | SLC39A9 | 0.651025 | 4 | 0 | 3 |
| SCN8A | IL1RL1 | 0.649797 | 3 | 0 | 3 |
| SCN8A | FCAR | 0.647132 | 4 | 0 | 4 |
| SCN8A | RHPN1-AS1 | 0.645337 | 4 | 0 | 4 |
For details and further investigation, click here
