| Full name: killer cell lectin like receptor C1 | Alias Symbol: NKG2-A|NKG2-B|CD159a | ||
| Type: protein-coding gene | Cytoband: 12p13 | ||
| Entrez ID: 3821 | HGNC ID: HGNC:6374 | Ensembl Gene: ENSG00000134545 | OMIM ID: 161555 |
| Drug and gene relationship at DGIdb | |||
KLRC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of KLRC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | KLRC1 | 3821 | 84807 | -0.1866 | 0.4018 | |
| GSE53624 | KLRC1 | 3821 | 84807 | -0.2150 | 0.2866 | |
| GSE97050 | KLRC1 | 3821 | A_23_P151046 | 0.0896 | 0.8395 | |
| SRP133303 | KLRC1 | 3821 | RNAseq | -0.2100 | 0.6733 | |
| SRP219564 | KLRC1 | 3821 | RNAseq | 1.0495 | 0.0599 | |
| TCGA | KLRC1 | 3821 | RNAseq | 0.1535 | 0.7892 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLRC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLRC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLRC1 | 3821 | 6 | 2 | 22 | |
| GSE20123 | KLRC1 | 3821 | 6 | 2 | 22 | |
| GSE43470 | KLRC1 | 3821 | 9 | 3 | 31 | |
| GSE46452 | KLRC1 | 3821 | 10 | 1 | 48 | |
| GSE47630 | KLRC1 | 3821 | 14 | 2 | 24 | |
| GSE54993 | KLRC1 | 3821 | 1 | 10 | 59 | |
| GSE54994 | KLRC1 | 3821 | 9 | 2 | 42 | |
| GSE60625 | KLRC1 | 3821 | 0 | 1 | 10 | |
| GSE74703 | KLRC1 | 3821 | 9 | 2 | 25 | |
| GSE74704 | KLRC1 | 3821 | 4 | 1 | 15 | |
| TCGA | KLRC1 | 3821 | 39 | 6 | 51 |
Total number of gains: 107; Total number of losses: 32; Total Number of normals: 349.
Somatic mutations of KLRC1:
Generating mutation plots.
Highly correlated genes for KLRC1:
Showing all 14 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLRC1 | IL15 | 0.715559 | 3 | 0 | 3 |
| KLRC1 | GZMA | 0.679834 | 3 | 0 | 3 |
| KLRC1 | ITK | 0.660051 | 3 | 0 | 3 |
| KLRC1 | NKG7 | 0.658675 | 3 | 0 | 3 |
| KLRC1 | CCL5 | 0.652943 | 3 | 0 | 3 |
| KLRC1 | GPR171 | 0.639823 | 3 | 0 | 3 |
| KLRC1 | CD226 | 0.635946 | 3 | 0 | 3 |
| KLRC1 | GIMAP5 | 0.600857 | 3 | 0 | 3 |
| KLRC1 | ACSL5 | 0.595543 | 3 | 0 | 3 |
| KLRC1 | TRIM22 | 0.570956 | 3 | 0 | 3 |
| KLRC1 | NCKAP1L | 0.567827 | 3 | 0 | 3 |
| KLRC1 | CST7 | 0.566234 | 3 | 0 | 3 |
| KLRC1 | SLAMF1 | 0.562845 | 3 | 0 | 3 |
| KLRC1 | GIMAP2 | 0.551741 | 3 | 0 | 3 |
For details and further investigation, click here
