| Full name: acyl-CoA synthetase long chain family member 5 | Alias Symbol: ACS5|ACS2 | ||
| Type: protein-coding gene | Cytoband: 10q25.2 | ||
| Entrez ID: 51703 | HGNC ID: HGNC:16526 | Ensembl Gene: ENSG00000197142 | OMIM ID: 605677 |
| Drug and gene relationship at DGIdb | |||
ACSL5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway |
Expression of ACSL5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACSL5 | 51703 | 222592_s_at | 0.0478 | 0.9742 | |
| GSE20347 | ACSL5 | 51703 | 218322_s_at | -0.6820 | 0.0155 | |
| GSE23400 | ACSL5 | 51703 | 218322_s_at | -0.3668 | 0.0000 | |
| GSE26886 | ACSL5 | 51703 | 222592_s_at | -0.7154 | 0.2179 | |
| GSE29001 | ACSL5 | 51703 | 218322_s_at | -0.3059 | 0.4112 | |
| GSE38129 | ACSL5 | 51703 | 218322_s_at | -0.9503 | 0.0000 | |
| GSE45670 | ACSL5 | 51703 | 222592_s_at | 0.1324 | 0.7587 | |
| GSE53622 | ACSL5 | 51703 | 131339 | -0.9415 | 0.0000 | |
| GSE53624 | ACSL5 | 51703 | 131339 | -0.8858 | 0.0000 | |
| GSE63941 | ACSL5 | 51703 | 222592_s_at | -0.7527 | 0.5436 | |
| GSE77861 | ACSL5 | 51703 | 218322_s_at | -0.3002 | 0.2430 | |
| GSE97050 | ACSL5 | 51703 | A_33_P3217983 | 0.0891 | 0.8106 | |
| SRP007169 | ACSL5 | 51703 | RNAseq | -1.6244 | 0.0090 | |
| SRP008496 | ACSL5 | 51703 | RNAseq | -1.5092 | 0.0002 | |
| SRP064894 | ACSL5 | 51703 | RNAseq | -0.2453 | 0.2923 | |
| SRP133303 | ACSL5 | 51703 | RNAseq | -0.1717 | 0.5512 | |
| SRP159526 | ACSL5 | 51703 | RNAseq | -1.4542 | 0.0335 | |
| SRP193095 | ACSL5 | 51703 | RNAseq | -0.6829 | 0.0835 | |
| SRP219564 | ACSL5 | 51703 | RNAseq | 0.4136 | 0.3706 | |
| TCGA | ACSL5 | 51703 | RNAseq | -0.5843 | 0.0016 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ACSL5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACSL5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACSL5 | 51703 | 1 | 9 | 20 | |
| GSE20123 | ACSL5 | 51703 | 1 | 8 | 21 | |
| GSE43470 | ACSL5 | 51703 | 0 | 9 | 34 | |
| GSE46452 | ACSL5 | 51703 | 0 | 11 | 48 | |
| GSE47630 | ACSL5 | 51703 | 2 | 14 | 24 | |
| GSE54993 | ACSL5 | 51703 | 8 | 0 | 62 | |
| GSE54994 | ACSL5 | 51703 | 1 | 10 | 42 | |
| GSE60625 | ACSL5 | 51703 | 0 | 0 | 11 | |
| GSE74703 | ACSL5 | 51703 | 0 | 6 | 30 | |
| GSE74704 | ACSL5 | 51703 | 1 | 4 | 15 | |
| TCGA | ACSL5 | 51703 | 4 | 29 | 63 |
Total number of gains: 18; Total number of losses: 100; Total Number of normals: 370.
Somatic mutations of ACSL5:
Generating mutation plots.
Highly correlated genes for ACSL5:
Showing top 20/412 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACSL5 | TMEM219 | 0.747395 | 3 | 0 | 3 |
| ACSL5 | AP3M1 | 0.727788 | 3 | 0 | 3 |
| ACSL5 | NCK1 | 0.722092 | 3 | 0 | 3 |
| ACSL5 | RPS24 | 0.71524 | 3 | 0 | 3 |
| ACSL5 | CREBL2 | 0.714962 | 3 | 0 | 3 |
| ACSL5 | GIMAP5 | 0.712903 | 4 | 0 | 3 |
| ACSL5 | ROBO1 | 0.711936 | 3 | 0 | 3 |
| ACSL5 | ZNF300 | 0.71077 | 3 | 0 | 3 |
| ACSL5 | EI24 | 0.708625 | 3 | 0 | 3 |
| ACSL5 | UBA7 | 0.702218 | 4 | 0 | 4 |
| ACSL5 | ZNF347 | 0.699382 | 3 | 0 | 3 |
| ACSL5 | TOMM5 | 0.692833 | 3 | 0 | 3 |
| ACSL5 | CYYR1 | 0.688087 | 3 | 0 | 3 |
| ACSL5 | EIF1AY | 0.685225 | 3 | 0 | 3 |
| ACSL5 | ECSCR | 0.679816 | 3 | 0 | 3 |
| ACSL5 | PFKL | 0.678619 | 3 | 0 | 3 |
| ACSL5 | CNOT6L | 0.671886 | 6 | 0 | 6 |
| ACSL5 | GAB3 | 0.669529 | 5 | 0 | 4 |
| ACSL5 | GNGT2 | 0.669143 | 4 | 0 | 4 |
| ACSL5 | PARP15 | 0.66835 | 5 | 0 | 5 |
For details and further investigation, click here
