CCL5

 

Full name: C-C motif chemokine ligand 5 Alias Symbol: RANTES|SISd|TCP228|MGC17164
Type: protein-coding gene Cytoband: 17q12
Entrez ID: 6352 HGNC ID: HGNC:10632 Ensembl Gene: ENSG00000271503 OMIM ID: 187011
Drug and gene relationship at DGIdb

 

CCL5 involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05020Prion diseases
hsa05120Epithelial cell signaling in Helicobacter pylori infection

 

Expression of CCL5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CCL5 6352 1405_i_at 1.1668 0.5181
GSE20347 CCL5 6352 1405_i_at -0.5117 0.2100
GSE23400 CCL5 6352 204655_at 0.4597 0.0028
GSE26886 CCL5 6352 204655_at 1.6590 0.0125
GSE29001 CCL5 6352 204655_at 0.8071 0.0794
GSE38129 CCL5 6352 1405_i_at -0.3872 0.3357
GSE45670 CCL5 6352 1405_i_at 0.0886 0.8776
GSE53622 CCL5 6352 28525 0.4355 0.0254
GSE53624 CCL5 6352 28525 0.0824 0.6604
GSE63941 CCL5 6352 1555759_a_at 0.9787 0.2442
GSE77861 CCL5 6352 1555759_a_at -0.2072 0.3030
GSE97050 CCL5 6352 A_23_P152838 0.5759 0.2839
SRP007169 CCL5 6352 RNAseq -0.2795 0.6975
SRP064894 CCL5 6352 RNAseq 0.3702 0.3235
SRP133303 CCL5 6352 RNAseq 0.4424 0.2568
SRP159526 CCL5 6352 RNAseq -0.5444 0.4900
SRP193095 CCL5 6352 RNAseq 0.2331 0.3440
SRP219564 CCL5 6352 RNAseq 1.8676 0.0010
TCGA CCL5 6352 RNAseq 0.3119 0.1202

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by CCL5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CCL5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CCL5 6352 5 1 24
GSE20123 CCL5 6352 5 1 24
GSE43470 CCL5 6352 1 2 40
GSE46452 CCL5 6352 34 0 25
GSE47630 CCL5 6352 7 1 32
GSE54993 CCL5 6352 3 3 64
GSE54994 CCL5 6352 8 6 39
GSE60625 CCL5 6352 4 0 7
GSE74703 CCL5 6352 1 1 34
GSE74704 CCL5 6352 3 1 16
TCGA CCL5 6352 20 9 67

Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.  

 

Somatic mutations of CCL5:

 

Generating mutation plots.

 

Highly correlated genes for CCL5:

 

Showing top 20/436 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CCL5RCN10.788749303
CCL5TNFSF80.759403404
CCL5GNGT20.748462404
CCL5SAMD30.739946505
CCL5PIK3AP10.711129404
CCL5GOSR20.70979303
CCL5SNX200.708745504
CCL5UBTD20.708189303
CCL5PREX10.706567403
CCL5GZMA0.70642712011
CCL5SFR10.697097303
CCL5NKG70.69023712011
CCL5TIGIT0.689119606
CCL5DDX60L0.683724505
CCL5ACAP10.683105605
CCL5ARHGAP90.679773605
CCL5ASPH0.678458303
CCL5TNFAIP30.673949504
CCL5PARVG0.673262604
CCL5GRAP20.672809404

For details and further investigation, click here