| Full name: interleukin 15 | Alias Symbol: IL-15|MGC9721 | ||
| Type: protein-coding gene | Cytoband: 4q31.21 | ||
| Entrez ID: 3600 | HGNC ID: HGNC:5977 | Ensembl Gene: ENSG00000164136 | OMIM ID: 600554 |
| Drug and gene relationship at DGIdb | |||
IL15 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL15 | 3600 | 205992_s_at | 0.4831 | 0.5780 | |
| GSE20347 | IL15 | 3600 | 205992_s_at | 0.0242 | 0.9440 | |
| GSE23400 | IL15 | 3600 | 205992_s_at | 0.3283 | 0.0010 | |
| GSE26886 | IL15 | 3600 | 205992_s_at | 1.3694 | 0.0528 | |
| GSE29001 | IL15 | 3600 | 205992_s_at | 0.5367 | 0.2167 | |
| GSE38129 | IL15 | 3600 | 205992_s_at | 0.0812 | 0.8086 | |
| GSE45670 | IL15 | 3600 | 205992_s_at | 0.3712 | 0.3919 | |
| GSE53622 | IL15 | 3600 | 18746 | -0.3043 | 0.1058 | |
| GSE53624 | IL15 | 3600 | 18746 | 0.0730 | 0.5860 | |
| GSE63941 | IL15 | 3600 | 205992_s_at | -1.4671 | 0.1705 | |
| GSE77861 | IL15 | 3600 | 205992_s_at | -0.2763 | 0.3464 | |
| GSE97050 | IL15 | 3600 | A_23_P29953 | 0.1659 | 0.5124 | |
| SRP007169 | IL15 | 3600 | RNAseq | -0.2239 | 0.7488 | |
| SRP064894 | IL15 | 3600 | RNAseq | 0.1539 | 0.4822 | |
| SRP133303 | IL15 | 3600 | RNAseq | 0.8150 | 0.0000 | |
| SRP159526 | IL15 | 3600 | RNAseq | 0.1567 | 0.7752 | |
| SRP193095 | IL15 | 3600 | RNAseq | 0.4938 | 0.0021 | |
| SRP219564 | IL15 | 3600 | RNAseq | 0.8070 | 0.0067 | |
| TCGA | IL15 | 3600 | RNAseq | 0.3589 | 0.0346 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL15 | 3600 | 0 | 12 | 18 | |
| GSE20123 | IL15 | 3600 | 0 | 12 | 18 | |
| GSE43470 | IL15 | 3600 | 0 | 13 | 30 | |
| GSE46452 | IL15 | 3600 | 1 | 36 | 22 | |
| GSE47630 | IL15 | 3600 | 0 | 22 | 18 | |
| GSE54993 | IL15 | 3600 | 10 | 0 | 60 | |
| GSE54994 | IL15 | 3600 | 2 | 11 | 40 | |
| GSE60625 | IL15 | 3600 | 0 | 1 | 10 | |
| GSE74703 | IL15 | 3600 | 0 | 11 | 25 | |
| GSE74704 | IL15 | 3600 | 0 | 6 | 14 | |
| TCGA | IL15 | 3600 | 13 | 30 | 53 |
Total number of gains: 26; Total number of losses: 154; Total Number of normals: 308.
Somatic mutations of IL15:
Generating mutation plots.
Highly correlated genes for IL15:
Showing top 20/476 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL15 | WDR81 | 0.780956 | 3 | 0 | 3 |
| IL15 | PREX1 | 0.762005 | 3 | 0 | 3 |
| IL15 | KLRC1 | 0.715559 | 3 | 0 | 3 |
| IL15 | DDX60L | 0.710663 | 5 | 0 | 5 |
| IL15 | ZNF7 | 0.701153 | 4 | 0 | 4 |
| IL15 | ZNF267 | 0.696507 | 3 | 0 | 3 |
| IL15 | CCDC102B | 0.69281 | 5 | 0 | 4 |
| IL15 | ASPH | 0.688485 | 4 | 0 | 4 |
| IL15 | NOC3L | 0.68128 | 4 | 0 | 4 |
| IL15 | ARHGAP18 | 0.679528 | 5 | 0 | 4 |
| IL15 | GZMA | 0.678298 | 12 | 0 | 11 |
| IL15 | KLHL7 | 0.676018 | 3 | 0 | 3 |
| IL15 | GXYLT2 | 0.675622 | 3 | 0 | 3 |
| IL15 | LRRC14 | 0.674834 | 3 | 0 | 3 |
| IL15 | SAMSN1 | 0.672243 | 8 | 0 | 7 |
| IL15 | IGSF6 | 0.669027 | 7 | 0 | 6 |
| IL15 | ENG | 0.668612 | 3 | 0 | 3 |
| IL15 | CD86 | 0.666631 | 7 | 0 | 5 |
| IL15 | UTP23 | 0.662324 | 3 | 0 | 3 |
| IL15 | RNF114 | 0.661713 | 4 | 0 | 3 |
For details and further investigation, click here
