| Full name: pseudouridine synthase 3 | Alias Symbol: FKSG32 | ||
| Type: protein-coding gene | Cytoband: 11q24.2 | ||
| Entrez ID: 83480 | HGNC ID: HGNC:25461 | Ensembl Gene: ENSG00000110060 | OMIM ID: 616283 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PUS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PUS3 | 83480 | 221277_s_at | 0.3054 | 0.6194 | |
| GSE20347 | PUS3 | 83480 | 221277_s_at | 0.0758 | 0.6911 | |
| GSE23400 | PUS3 | 83480 | 221277_s_at | 0.0474 | 0.4345 | |
| GSE26886 | PUS3 | 83480 | 221277_s_at | 0.3716 | 0.2097 | |
| GSE29001 | PUS3 | 83480 | 221277_s_at | -0.0177 | 0.9706 | |
| GSE38129 | PUS3 | 83480 | 221277_s_at | 0.0493 | 0.7358 | |
| GSE45670 | PUS3 | 83480 | 221277_s_at | 0.1507 | 0.3585 | |
| GSE53622 | PUS3 | 83480 | 65093 | 0.1092 | 0.1089 | |
| GSE53624 | PUS3 | 83480 | 65093 | 0.1285 | 0.0516 | |
| GSE63941 | PUS3 | 83480 | 221277_s_at | -0.6649 | 0.2069 | |
| GSE77861 | PUS3 | 83480 | 221277_s_at | 0.2114 | 0.3796 | |
| GSE97050 | PUS3 | 83480 | A_23_P13073 | 0.2416 | 0.2802 | |
| SRP007169 | PUS3 | 83480 | RNAseq | 0.3665 | 0.5134 | |
| SRP064894 | PUS3 | 83480 | RNAseq | -0.1167 | 0.4779 | |
| SRP133303 | PUS3 | 83480 | RNAseq | -0.0122 | 0.9197 | |
| SRP159526 | PUS3 | 83480 | RNAseq | -0.2464 | 0.3699 | |
| SRP193095 | PUS3 | 83480 | RNAseq | -0.4554 | 0.0000 | |
| SRP219564 | PUS3 | 83480 | RNAseq | -0.3513 | 0.3530 | |
| TCGA | PUS3 | 83480 | RNAseq | -0.1909 | 0.0069 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PUS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PUS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PUS3 | 83480 | 0 | 13 | 17 | |
| GSE20123 | PUS3 | 83480 | 0 | 13 | 17 | |
| GSE43470 | PUS3 | 83480 | 2 | 7 | 34 | |
| GSE46452 | PUS3 | 83480 | 3 | 26 | 30 | |
| GSE47630 | PUS3 | 83480 | 2 | 19 | 19 | |
| GSE54993 | PUS3 | 83480 | 10 | 0 | 60 | |
| GSE54994 | PUS3 | 83480 | 5 | 19 | 29 | |
| GSE60625 | PUS3 | 83480 | 0 | 3 | 8 | |
| GSE74703 | PUS3 | 83480 | 1 | 5 | 30 | |
| GSE74704 | PUS3 | 83480 | 0 | 9 | 11 | |
| TCGA | PUS3 | 83480 | 6 | 50 | 40 |
Total number of gains: 29; Total number of losses: 164; Total Number of normals: 295.
Somatic mutations of PUS3:
Generating mutation plots.
Highly correlated genes for PUS3:
Showing top 20/186 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PUS3 | DDX31 | 0.723845 | 3 | 0 | 3 |
| PUS3 | CARS2 | 0.709385 | 3 | 0 | 3 |
| PUS3 | DENND4B | 0.705127 | 3 | 0 | 3 |
| PUS3 | DHX16 | 0.687483 | 3 | 0 | 3 |
| PUS3 | EXOSC10 | 0.675809 | 3 | 0 | 3 |
| PUS3 | MS4A14 | 0.672976 | 3 | 0 | 3 |
| PUS3 | ACSL1 | 0.66468 | 3 | 0 | 3 |
| PUS3 | POLR3C | 0.659244 | 4 | 0 | 4 |
| PUS3 | ARV1 | 0.657489 | 3 | 0 | 3 |
| PUS3 | DDX55 | 0.657388 | 3 | 0 | 3 |
| PUS3 | CCR1 | 0.653997 | 3 | 0 | 3 |
| PUS3 | KIN | 0.642941 | 4 | 0 | 3 |
| PUS3 | GTF2H1 | 0.634227 | 5 | 0 | 3 |
| PUS3 | DTNBP1 | 0.632861 | 3 | 0 | 3 |
| PUS3 | DDX39A | 0.628081 | 3 | 0 | 3 |
| PUS3 | KIR2DL4 | 0.625954 | 3 | 0 | 3 |
| PUS3 | TARBP1 | 0.614174 | 4 | 0 | 3 |
| PUS3 | MIA3 | 0.610681 | 3 | 0 | 3 |
| PUS3 | DUSP23 | 0.610257 | 4 | 0 | 3 |
| PUS3 | DNAJC24 | 0.609588 | 3 | 0 | 3 |
For details and further investigation, click here
