| Full name: Rho guanine nucleotide exchange factor 12 | Alias Symbol: KIAA0382|LARG | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 23365 | HGNC ID: HGNC:14193 | Ensembl Gene: ENSG00000196914 | OMIM ID: 604763 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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ARHGEF12 involved pathways:
Expression of ARHGEF12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF12 | 23365 | 201334_s_at | -0.2943 | 0.1105 | |
| GSE20347 | ARHGEF12 | 23365 | 201334_s_at | -0.6926 | 0.0001 | |
| GSE23400 | ARHGEF12 | 23365 | 201334_s_at | -0.2220 | 0.0002 | |
| GSE26886 | ARHGEF12 | 23365 | 201334_s_at | -0.4068 | 0.0233 | |
| GSE29001 | ARHGEF12 | 23365 | 201334_s_at | -0.5600 | 0.0116 | |
| GSE38129 | ARHGEF12 | 23365 | 201334_s_at | -0.6902 | 0.0000 | |
| GSE45670 | ARHGEF12 | 23365 | 201334_s_at | -0.2187 | 0.0451 | |
| GSE53622 | ARHGEF12 | 23365 | 56482 | -0.5403 | 0.0000 | |
| GSE53624 | ARHGEF12 | 23365 | 56482 | -0.6128 | 0.0000 | |
| GSE63941 | ARHGEF12 | 23365 | 201334_s_at | -0.9714 | 0.0082 | |
| GSE77861 | ARHGEF12 | 23365 | 201334_s_at | -0.1385 | 0.5576 | |
| GSE97050 | ARHGEF12 | 23365 | A_24_P175783 | 0.0375 | 0.8912 | |
| SRP007169 | ARHGEF12 | 23365 | RNAseq | -0.2949 | 0.3958 | |
| SRP008496 | ARHGEF12 | 23365 | RNAseq | 0.0549 | 0.7932 | |
| SRP064894 | ARHGEF12 | 23365 | RNAseq | -0.6552 | 0.0149 | |
| SRP133303 | ARHGEF12 | 23365 | RNAseq | -0.3173 | 0.0102 | |
| SRP159526 | ARHGEF12 | 23365 | RNAseq | -0.7913 | 0.0044 | |
| SRP193095 | ARHGEF12 | 23365 | RNAseq | -0.6935 | 0.0000 | |
| SRP219564 | ARHGEF12 | 23365 | RNAseq | -0.7511 | 0.0471 | |
| TCGA | ARHGEF12 | 23365 | RNAseq | -0.1664 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARHGEF12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF12 | 23365 | 1 | 12 | 17 | |
| GSE20123 | ARHGEF12 | 23365 | 1 | 12 | 17 | |
| GSE43470 | ARHGEF12 | 23365 | 2 | 8 | 33 | |
| GSE46452 | ARHGEF12 | 23365 | 3 | 26 | 30 | |
| GSE47630 | ARHGEF12 | 23365 | 2 | 19 | 19 | |
| GSE54993 | ARHGEF12 | 23365 | 10 | 0 | 60 | |
| GSE54994 | ARHGEF12 | 23365 | 5 | 19 | 29 | |
| GSE60625 | ARHGEF12 | 23365 | 0 | 3 | 8 | |
| GSE74703 | ARHGEF12 | 23365 | 1 | 5 | 30 | |
| GSE74704 | ARHGEF12 | 23365 | 0 | 8 | 12 | |
| TCGA | ARHGEF12 | 23365 | 5 | 50 | 41 |
Total number of gains: 30; Total number of losses: 162; Total Number of normals: 296.
Somatic mutations of ARHGEF12:
Generating mutation plots.
Highly correlated genes for ARHGEF12:
Showing top 20/501 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF12 | PRMT2 | 0.661382 | 6 | 0 | 6 |
| ARHGEF12 | SDHD | 0.658587 | 10 | 0 | 8 |
| ARHGEF12 | RABGAP1L | 0.656515 | 6 | 0 | 5 |
| ARHGEF12 | STT3B | 0.655955 | 4 | 0 | 3 |
| ARHGEF12 | CCBE1 | 0.646158 | 4 | 0 | 3 |
| ARHGEF12 | YAP1 | 0.645512 | 5 | 0 | 4 |
| ARHGEF12 | ARHGAP20 | 0.636602 | 4 | 0 | 3 |
| ARHGEF12 | FGF10 | 0.636381 | 3 | 0 | 3 |
| ARHGEF12 | PDE8B | 0.635381 | 3 | 0 | 3 |
| ARHGEF12 | UBE4A | 0.633948 | 9 | 0 | 8 |
| ARHGEF12 | SMDT1 | 0.633794 | 3 | 0 | 3 |
| ARHGEF12 | LRP10 | 0.629461 | 7 | 0 | 6 |
| ARHGEF12 | KLHL20 | 0.628819 | 4 | 0 | 4 |
| ARHGEF12 | SLC25A43 | 0.622984 | 3 | 0 | 3 |
| ARHGEF12 | PTN | 0.622179 | 6 | 0 | 5 |
| ARHGEF12 | SIK2 | 0.621019 | 5 | 0 | 5 |
| ARHGEF12 | VPS13D | 0.618634 | 8 | 0 | 7 |
| ARHGEF12 | KMT2A | 0.609338 | 5 | 0 | 5 |
| ARHGEF12 | CES2 | 0.607497 | 7 | 0 | 5 |
| ARHGEF12 | RAPGEFL1 | 0.607132 | 6 | 0 | 5 |
For details and further investigation, click here
