| Full name: DDHD domain containing 2 | Alias Symbol: KIAA0725|SPG54 | ||
| Type: protein-coding gene | Cytoband: 8p11.23 | ||
| Entrez ID: 23259 | HGNC ID: HGNC:29106 | Ensembl Gene: ENSG00000085788 | OMIM ID: 615003 |
| Drug and gene relationship at DGIdb | |||
Expression of DDHD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDHD2 | 23259 | 212690_at | -0.2791 | 0.6645 | |
| GSE20347 | DDHD2 | 23259 | 212690_at | 0.5728 | 0.0463 | |
| GSE23400 | DDHD2 | 23259 | 212690_at | 0.3997 | 0.0130 | |
| GSE26886 | DDHD2 | 23259 | 212690_at | 0.4525 | 0.1764 | |
| GSE29001 | DDHD2 | 23259 | 212690_at | 0.5866 | 0.0751 | |
| GSE38129 | DDHD2 | 23259 | 212690_at | 0.1891 | 0.4898 | |
| GSE45670 | DDHD2 | 23259 | 212690_at | -0.4993 | 0.0134 | |
| GSE53622 | DDHD2 | 23259 | 36494 | 0.2809 | 0.0053 | |
| GSE53624 | DDHD2 | 23259 | 36494 | 0.3338 | 0.0000 | |
| GSE63941 | DDHD2 | 23259 | 212690_at | -1.5767 | 0.0036 | |
| GSE77861 | DDHD2 | 23259 | 212690_at | 0.6369 | 0.3592 | |
| GSE97050 | DDHD2 | 23259 | A_23_P157600 | -0.4178 | 0.2850 | |
| SRP007169 | DDHD2 | 23259 | RNAseq | 1.6791 | 0.0036 | |
| SRP008496 | DDHD2 | 23259 | RNAseq | 1.4126 | 0.0001 | |
| SRP064894 | DDHD2 | 23259 | RNAseq | -0.1408 | 0.5291 | |
| SRP133303 | DDHD2 | 23259 | RNAseq | 0.3336 | 0.0254 | |
| SRP159526 | DDHD2 | 23259 | RNAseq | 0.5269 | 0.2021 | |
| SRP193095 | DDHD2 | 23259 | RNAseq | 0.5666 | 0.0001 | |
| SRP219564 | DDHD2 | 23259 | RNAseq | -0.1484 | 0.6852 | |
| TCGA | DDHD2 | 23259 | RNAseq | -0.1056 | 0.1022 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by DDHD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDHD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDHD2 | 23259 | 10 | 4 | 16 | |
| GSE20123 | DDHD2 | 23259 | 11 | 4 | 15 | |
| GSE43470 | DDHD2 | 23259 | 8 | 7 | 28 | |
| GSE46452 | DDHD2 | 23259 | 21 | 5 | 33 | |
| GSE47630 | DDHD2 | 23259 | 12 | 7 | 21 | |
| GSE54993 | DDHD2 | 23259 | 2 | 16 | 52 | |
| GSE54994 | DDHD2 | 23259 | 16 | 8 | 29 | |
| GSE60625 | DDHD2 | 23259 | 3 | 0 | 8 | |
| GSE74703 | DDHD2 | 23259 | 8 | 5 | 23 | |
| GSE74704 | DDHD2 | 23259 | 9 | 1 | 10 | |
| TCGA | DDHD2 | 23259 | 36 | 24 | 36 |
Total number of gains: 136; Total number of losses: 81; Total Number of normals: 271.
Somatic mutations of DDHD2:
Generating mutation plots.
Highly correlated genes for DDHD2:
Showing top 20/670 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDHD2 | KIF13A | 0.764784 | 3 | 0 | 3 |
| DDHD2 | PJA2 | 0.75182 | 3 | 0 | 3 |
| DDHD2 | CTPS2 | 0.716424 | 3 | 0 | 3 |
| DDHD2 | FNIP2 | 0.713251 | 4 | 0 | 3 |
| DDHD2 | CLDN12 | 0.710266 | 3 | 0 | 3 |
| DDHD2 | BTG2 | 0.698717 | 3 | 0 | 3 |
| DDHD2 | MRGPRF | 0.692647 | 4 | 0 | 4 |
| DDHD2 | UBR1 | 0.681291 | 4 | 0 | 4 |
| DDHD2 | SLC25A30 | 0.681121 | 4 | 0 | 4 |
| DDHD2 | CYTH3 | 0.680713 | 3 | 0 | 3 |
| DDHD2 | SEMA3A | 0.68009 | 4 | 0 | 4 |
| DDHD2 | DSEL | 0.678864 | 4 | 0 | 3 |
| DDHD2 | INTS10 | 0.678551 | 4 | 0 | 4 |
| DDHD2 | CRLS1 | 0.676689 | 3 | 0 | 3 |
| DDHD2 | KPNA3 | 0.676006 | 3 | 0 | 3 |
| DDHD2 | LSM14A | 0.671773 | 4 | 0 | 3 |
| DDHD2 | C20orf194 | 0.67134 | 5 | 0 | 5 |
| DDHD2 | BBS7 | 0.669919 | 5 | 0 | 5 |
| DDHD2 | LSM1 | 0.667393 | 9 | 0 | 9 |
| DDHD2 | EIF2AK4 | 0.66655 | 4 | 0 | 4 |
For details and further investigation, click here
