| Full name: 8-oxoguanine DNA glycosylase | Alias Symbol: HMMH|HOGG1|OGH1|MUTM | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 4968 | HGNC ID: HGNC:8125 | Ensembl Gene: ENSG00000114026 | OMIM ID: 601982 |
| Drug and gene relationship at DGIdb | |||
Expression of OGG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OGG1 | 4968 | 205760_s_at | -0.0360 | 0.9518 | |
| GSE20347 | OGG1 | 4968 | 205301_s_at | 0.0386 | 0.7681 | |
| GSE23400 | OGG1 | 4968 | 205760_s_at | -0.1567 | 0.0001 | |
| GSE26886 | OGG1 | 4968 | 205301_s_at | 0.3887 | 0.0180 | |
| GSE29001 | OGG1 | 4968 | 205760_s_at | -0.1233 | 0.6512 | |
| GSE38129 | OGG1 | 4968 | 205760_s_at | -0.2905 | 0.0202 | |
| GSE45670 | OGG1 | 4968 | 205760_s_at | -0.4438 | 0.0077 | |
| GSE53622 | OGG1 | 4968 | 15954 | 0.4078 | 0.0000 | |
| GSE53624 | OGG1 | 4968 | 15954 | 0.3529 | 0.0000 | |
| GSE63941 | OGG1 | 4968 | 205760_s_at | 0.2881 | 0.6380 | |
| GSE77861 | OGG1 | 4968 | 205301_s_at | -0.0437 | 0.7817 | |
| GSE97050 | OGG1 | 4968 | A_23_P212196 | -0.2442 | 0.2501 | |
| SRP007169 | OGG1 | 4968 | RNAseq | 1.0185 | 0.1596 | |
| SRP064894 | OGG1 | 4968 | RNAseq | 0.4369 | 0.0250 | |
| SRP133303 | OGG1 | 4968 | RNAseq | -0.2617 | 0.0411 | |
| SRP159526 | OGG1 | 4968 | RNAseq | -0.1643 | 0.5466 | |
| SRP193095 | OGG1 | 4968 | RNAseq | -0.0549 | 0.7012 | |
| SRP219564 | OGG1 | 4968 | RNAseq | 0.0593 | 0.8966 | |
| TCGA | OGG1 | 4968 | RNAseq | -0.0687 | 0.3040 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by OGG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OGG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OGG1 | 4968 | 1 | 18 | 11 | |
| GSE20123 | OGG1 | 4968 | 1 | 18 | 11 | |
| GSE43470 | OGG1 | 4968 | 1 | 20 | 22 | |
| GSE46452 | OGG1 | 4968 | 2 | 17 | 40 | |
| GSE47630 | OGG1 | 4968 | 3 | 22 | 15 | |
| GSE54993 | OGG1 | 4968 | 6 | 1 | 63 | |
| GSE54994 | OGG1 | 4968 | 3 | 31 | 19 | |
| GSE60625 | OGG1 | 4968 | 5 | 0 | 6 | |
| GSE74703 | OGG1 | 4968 | 1 | 16 | 19 | |
| GSE74704 | OGG1 | 4968 | 1 | 11 | 8 | |
| TCGA | OGG1 | 4968 | 5 | 65 | 26 |
Total number of gains: 29; Total number of losses: 219; Total Number of normals: 240.
Somatic mutations of OGG1:
Generating mutation plots.
Highly correlated genes for OGG1:
Showing top 20/399 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OGG1 | RILP | 0.814114 | 3 | 0 | 3 |
| OGG1 | INO80E | 0.795053 | 3 | 0 | 3 |
| OGG1 | PFDN1 | 0.785042 | 3 | 0 | 3 |
| OGG1 | MEIS3 | 0.75734 | 3 | 0 | 3 |
| OGG1 | EPN1 | 0.746488 | 4 | 0 | 4 |
| OGG1 | ARFRP1 | 0.741768 | 3 | 0 | 3 |
| OGG1 | MIER2 | 0.727704 | 4 | 0 | 4 |
| OGG1 | SSNA1 | 0.726559 | 3 | 0 | 3 |
| OGG1 | ELAVL3 | 0.711423 | 3 | 0 | 3 |
| OGG1 | STK32B | 0.711081 | 3 | 0 | 3 |
| OGG1 | SNX15 | 0.710136 | 3 | 0 | 3 |
| OGG1 | FHL3 | 0.706555 | 4 | 0 | 3 |
| OGG1 | PIN4 | 0.706193 | 4 | 0 | 4 |
| OGG1 | VPS28 | 0.704653 | 3 | 0 | 3 |
| OGG1 | ABI2 | 0.703409 | 3 | 0 | 3 |
| OGG1 | SUGP1 | 0.702847 | 4 | 0 | 4 |
| OGG1 | RBPJ | 0.698956 | 4 | 0 | 4 |
| OGG1 | C9orf50 | 0.69337 | 3 | 0 | 3 |
| OGG1 | UGGT2 | 0.693358 | 3 | 0 | 3 |
| OGG1 | EBF1 | 0.692453 | 3 | 0 | 3 |
For details and further investigation, click here
