| Full name: VPS11 core subunit of CORVET and HOPS complexes | Alias Symbol: RNF108|PEP5 | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 55823 | HGNC ID: HGNC:14583 | Ensembl Gene: ENSG00000160695 | OMIM ID: 608549 |
| Drug and gene relationship at DGIdb | |||
Expression of VPS11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS11 | 55823 | 203292_s_at | -0.1688 | 0.3859 | |
| GSE20347 | VPS11 | 55823 | 203292_s_at | -0.1781 | 0.0502 | |
| GSE23400 | VPS11 | 55823 | 203292_s_at | -0.1607 | 0.0000 | |
| GSE26886 | VPS11 | 55823 | 203292_s_at | 0.4407 | 0.0033 | |
| GSE29001 | VPS11 | 55823 | 203292_s_at | -0.2322 | 0.2848 | |
| GSE38129 | VPS11 | 55823 | 203292_s_at | -0.3391 | 0.0000 | |
| GSE45670 | VPS11 | 55823 | 203292_s_at | -0.2867 | 0.0047 | |
| GSE53622 | VPS11 | 55823 | 15752 | -0.3130 | 0.0000 | |
| GSE53624 | VPS11 | 55823 | 15752 | -0.3482 | 0.0000 | |
| GSE63941 | VPS11 | 55823 | 203292_s_at | -0.6305 | 0.0904 | |
| GSE77861 | VPS11 | 55823 | 203292_s_at | -0.0401 | 0.8396 | |
| GSE97050 | VPS11 | 55823 | A_24_P329939 | -0.3880 | 0.1861 | |
| SRP007169 | VPS11 | 55823 | RNAseq | -1.0687 | 0.0025 | |
| SRP008496 | VPS11 | 55823 | RNAseq | -0.8174 | 0.0003 | |
| SRP064894 | VPS11 | 55823 | RNAseq | -0.1132 | 0.3104 | |
| SRP133303 | VPS11 | 55823 | RNAseq | -0.4561 | 0.0066 | |
| SRP159526 | VPS11 | 55823 | RNAseq | -0.4303 | 0.0711 | |
| SRP193095 | VPS11 | 55823 | RNAseq | -0.4780 | 0.0000 | |
| SRP219564 | VPS11 | 55823 | RNAseq | -0.2208 | 0.4509 | |
| TCGA | VPS11 | 55823 | RNAseq | -0.1987 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by VPS11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS11 | 55823 | 1 | 11 | 18 | |
| GSE20123 | VPS11 | 55823 | 1 | 11 | 18 | |
| GSE43470 | VPS11 | 55823 | 2 | 8 | 33 | |
| GSE46452 | VPS11 | 55823 | 3 | 26 | 30 | |
| GSE47630 | VPS11 | 55823 | 2 | 19 | 19 | |
| GSE54993 | VPS11 | 55823 | 10 | 0 | 60 | |
| GSE54994 | VPS11 | 55823 | 5 | 19 | 29 | |
| GSE60625 | VPS11 | 55823 | 0 | 3 | 8 | |
| GSE74703 | VPS11 | 55823 | 1 | 5 | 30 | |
| GSE74704 | VPS11 | 55823 | 0 | 7 | 13 | |
| TCGA | VPS11 | 55823 | 4 | 51 | 41 |
Total number of gains: 29; Total number of losses: 160; Total Number of normals: 299.
Somatic mutations of VPS11:
Generating mutation plots.
Highly correlated genes for VPS11:
Showing top 20/440 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS11 | NR1H2 | 0.733398 | 3 | 0 | 3 |
| VPS11 | CD99 | 0.719761 | 3 | 0 | 3 |
| VPS11 | INO80 | 0.708604 | 3 | 0 | 3 |
| VPS11 | NUPR1 | 0.701763 | 4 | 0 | 4 |
| VPS11 | EEF2 | 0.69873 | 4 | 0 | 3 |
| VPS11 | CYP4V2 | 0.691162 | 3 | 0 | 3 |
| VPS11 | USP28 | 0.685858 | 3 | 0 | 3 |
| VPS11 | PDCD4 | 0.674292 | 3 | 0 | 3 |
| VPS11 | HINT2 | 0.665803 | 3 | 0 | 3 |
| VPS11 | KIAA1143 | 0.657541 | 3 | 0 | 3 |
| VPS11 | TTLL1 | 0.657342 | 4 | 0 | 4 |
| VPS11 | VPS26B | 0.657208 | 6 | 0 | 5 |
| VPS11 | TLN2 | 0.655928 | 3 | 0 | 3 |
| VPS11 | DVL1 | 0.647995 | 3 | 0 | 3 |
| VPS11 | KAT6B | 0.645393 | 5 | 0 | 4 |
| VPS11 | NFIX | 0.64455 | 7 | 0 | 5 |
| VPS11 | UFC1 | 0.642714 | 4 | 0 | 3 |
| VPS11 | PTAR1 | 0.641008 | 5 | 0 | 3 |
| VPS11 | COX7B | 0.639109 | 4 | 0 | 3 |
| VPS11 | DAGLA | 0.63747 | 3 | 0 | 3 |
For details and further investigation, click here
