KRIT1

 

Full name: KRIT1 ankyrin repeat containing Alias Symbol: CAM
Type: protein-coding gene Cytoband: 7q21.2
Entrez ID: 889 HGNC ID: HGNC:1573 Ensembl Gene: ENSG00000001631 OMIM ID: 604214
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

KRIT1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway

 

Expression of KRIT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KRIT1 889 34031_i_at 0.0580 0.9255
GSE20347 KRIT1 889 34031_i_at 0.3729 0.0244
GSE23400 KRIT1 889 204738_s_at 0.1704 0.0001
GSE26886 KRIT1 889 216713_at 0.2133 0.3285
GSE29001 KRIT1 889 216713_at 0.3882 0.0386
GSE38129 KRIT1 889 34031_i_at 0.3028 0.2958
GSE45670 KRIT1 889 216713_at 0.3970 0.0278
GSE53622 KRIT1 889 20749 0.3660 0.0693
GSE53624 KRIT1 889 20749 -0.0465 0.8126
GSE63941 KRIT1 889 34031_i_at 0.3550 0.5589
GSE77861 KRIT1 889 216713_at 0.1815 0.3621
SRP007169 KRIT1 889 RNAseq 0.6968 0.0353
SRP008496 KRIT1 889 RNAseq 0.9475 0.0001
SRP064894 KRIT1 889 RNAseq 0.1263 0.6553
SRP133303 KRIT1 889 RNAseq 0.4031 0.0015
SRP159526 KRIT1 889 RNAseq 0.2631 0.1561
SRP193095 KRIT1 889 RNAseq 0.4861 0.0020
SRP219564 KRIT1 889 RNAseq 0.2523 0.3962
TCGA KRIT1 889 RNAseq 0.0708 0.2801

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by KRIT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KRIT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KRIT1 889 13 0 17
GSE20123 KRIT1 889 13 0 17
GSE43470 KRIT1 889 6 1 36
GSE46452 KRIT1 889 11 0 48
GSE47630 KRIT1 889 9 2 29
GSE54993 KRIT1 889 1 8 61
GSE54994 KRIT1 889 16 2 35
GSE60625 KRIT1 889 0 0 11
GSE74703 KRIT1 889 5 1 30
GSE74704 KRIT1 889 9 0 11
TCGA KRIT1 889 56 4 36

Total number of gains: 139; Total number of losses: 18; Total Number of normals: 331.  

 

Somatic mutations of KRIT1:

 

Generating mutation plots.

 

Highly correlated genes for KRIT1:

 

Showing top 20/125 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KRIT1RBM480.722867706
KRIT1MTO10.678992303
KRIT1MED10.662054303
KRIT1INTU0.661186303
KRIT1POR0.634305303
KRIT1GSTCD0.634223504
KRIT1XPNPEP30.626592404
KRIT1ZRANB30.622527303
KRIT1BBS70.612372403
KRIT1TUBD10.611962403
KRIT1PHF140.604263605
KRIT1SNW10.600781303
KRIT1RWDD30.600734403
KRIT1DMTF10.593328807
KRIT1ZDHHC170.591881403
KRIT1PAWR0.590807403
KRIT1MTERF10.590465805
KRIT1TRIM50.589598303
KRIT1ZFC3H10.589011303
KRIT1CHD10.588809303

For details and further investigation, click here