| Full name: tripartite motif containing 5 | Alias Symbol: RNF88|TRIM5alpha | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 85363 | HGNC ID: HGNC:16276 | Ensembl Gene: ENSG00000132256 | OMIM ID: 608487 |
| Drug and gene relationship at DGIdb | |||
Expression of TRIM5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRIM5 | 85363 | 210705_s_at | -0.2495 | 0.5505 | |
| GSE20347 | TRIM5 | 85363 | 210705_s_at | -0.3209 | 0.1831 | |
| GSE23400 | TRIM5 | 85363 | 210705_s_at | 0.0233 | 0.7284 | |
| GSE26886 | TRIM5 | 85363 | 210705_s_at | 0.4460 | 0.0240 | |
| GSE29001 | TRIM5 | 85363 | 210705_s_at | 0.0577 | 0.8931 | |
| GSE38129 | TRIM5 | 85363 | 210705_s_at | -0.1998 | 0.2139 | |
| GSE45670 | TRIM5 | 85363 | 210705_s_at | 0.4948 | 0.1286 | |
| GSE53622 | TRIM5 | 85363 | 75614 | -0.0502 | 0.6403 | |
| GSE53624 | TRIM5 | 85363 | 17800 | 0.0490 | 0.7064 | |
| GSE63941 | TRIM5 | 85363 | 210705_s_at | -1.3505 | 0.0692 | |
| GSE77861 | TRIM5 | 85363 | 210705_s_at | -0.5928 | 0.1009 | |
| GSE97050 | TRIM5 | 85363 | A_23_P356526 | 0.0514 | 0.9050 | |
| SRP007169 | TRIM5 | 85363 | RNAseq | 0.0269 | 0.9474 | |
| SRP008496 | TRIM5 | 85363 | RNAseq | -0.0658 | 0.7940 | |
| SRP064894 | TRIM5 | 85363 | RNAseq | 0.3783 | 0.0538 | |
| SRP133303 | TRIM5 | 85363 | RNAseq | 0.0646 | 0.6455 | |
| SRP159526 | TRIM5 | 85363 | RNAseq | -0.6182 | 0.0755 | |
| SRP193095 | TRIM5 | 85363 | RNAseq | -0.0322 | 0.7872 | |
| SRP219564 | TRIM5 | 85363 | RNAseq | -0.0054 | 0.9889 | |
| TCGA | TRIM5 | 85363 | RNAseq | -0.0215 | 0.7779 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TRIM5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRIM5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRIM5 | 85363 | 1 | 11 | 18 | |
| GSE20123 | TRIM5 | 85363 | 1 | 11 | 18 | |
| GSE43470 | TRIM5 | 85363 | 1 | 8 | 34 | |
| GSE46452 | TRIM5 | 85363 | 7 | 8 | 44 | |
| GSE47630 | TRIM5 | 85363 | 3 | 13 | 24 | |
| GSE54993 | TRIM5 | 85363 | 3 | 1 | 66 | |
| GSE54994 | TRIM5 | 85363 | 2 | 12 | 39 | |
| GSE60625 | TRIM5 | 85363 | 0 | 0 | 11 | |
| GSE74703 | TRIM5 | 85363 | 1 | 6 | 29 | |
| GSE74704 | TRIM5 | 85363 | 0 | 8 | 12 | |
| TCGA | TRIM5 | 85363 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 117; Total Number of normals: 344.
Somatic mutations of TRIM5:
Generating mutation plots.
Highly correlated genes for TRIM5:
Showing top 20/391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRIM5 | SPA17 | 0.805805 | 3 | 0 | 3 |
| TRIM5 | IMPACT | 0.775468 | 3 | 0 | 3 |
| TRIM5 | ARHGEF3 | 0.767435 | 4 | 0 | 3 |
| TRIM5 | ACSL3 | 0.767051 | 3 | 0 | 3 |
| TRIM5 | SEC22A | 0.75565 | 3 | 0 | 3 |
| TRIM5 | ST3GAL5 | 0.745397 | 3 | 0 | 3 |
| TRIM5 | COPG2 | 0.741473 | 3 | 0 | 3 |
| TRIM5 | CHD1 | 0.741025 | 3 | 0 | 3 |
| TRIM5 | CCDC15 | 0.739272 | 3 | 0 | 3 |
| TRIM5 | WDR43 | 0.737987 | 3 | 0 | 3 |
| TRIM5 | STAT2 | 0.735141 | 4 | 0 | 3 |
| TRIM5 | BDH2 | 0.725789 | 3 | 0 | 3 |
| TRIM5 | PPFIBP2 | 0.724512 | 3 | 0 | 3 |
| TRIM5 | EXOC4 | 0.718421 | 3 | 0 | 3 |
| TRIM5 | SPAG16 | 0.717327 | 3 | 0 | 3 |
| TRIM5 | EEA1 | 0.715934 | 4 | 0 | 3 |
| TRIM5 | SARNP | 0.713969 | 3 | 0 | 3 |
| TRIM5 | HIPK3 | 0.713622 | 3 | 0 | 3 |
| TRIM5 | CMC1 | 0.711413 | 4 | 0 | 4 |
| TRIM5 | ITPRIP | 0.706482 | 3 | 0 | 3 |
For details and further investigation, click here
