| Full name: C-C motif chemokine ligand 17 | Alias Symbol: TARC|ABCD-2 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 6361 | HGNC ID: HGNC:10615 | Ensembl Gene: ENSG00000102970 | OMIM ID: 601520 |
| Drug and gene relationship at DGIdb | |||
CCL17 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCL17:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL17 | 6361 | 207900_at | -0.2010 | 0.5383 | |
| GSE20347 | CCL17 | 6361 | 207900_at | -0.2434 | 0.0011 | |
| GSE23400 | CCL17 | 6361 | 207900_at | -0.2063 | 0.0000 | |
| GSE26886 | CCL17 | 6361 | 207900_at | -0.6507 | 0.0000 | |
| GSE29001 | CCL17 | 6361 | 207900_at | -0.4087 | 0.0065 | |
| GSE38129 | CCL17 | 6361 | 207900_at | -0.1894 | 0.0639 | |
| GSE45670 | CCL17 | 6361 | 207900_at | -0.0997 | 0.4987 | |
| GSE53622 | CCL17 | 6361 | 5654 | -0.3090 | 0.0172 | |
| GSE53624 | CCL17 | 6361 | 5654 | -0.9110 | 0.0000 | |
| GSE63941 | CCL17 | 6361 | 207900_at | 0.2994 | 0.2146 | |
| GSE77861 | CCL17 | 6361 | 207900_at | -0.0779 | 0.4840 | |
| GSE97050 | CCL17 | 6361 | A_23_P26325 | 0.0323 | 0.8869 | |
| SRP064894 | CCL17 | 6361 | RNAseq | -0.7237 | 0.1059 | |
| SRP133303 | CCL17 | 6361 | RNAseq | -0.7033 | 0.0264 | |
| SRP159526 | CCL17 | 6361 | RNAseq | -1.5188 | 0.0739 | |
| SRP219564 | CCL17 | 6361 | RNAseq | 0.2802 | 0.7250 | |
| TCGA | CCL17 | 6361 | RNAseq | 1.4703 | 0.0058 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CCL17 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCL17:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL17 | 6361 | 6 | 0 | 24 | |
| GSE20123 | CCL17 | 6361 | 6 | 1 | 23 | |
| GSE43470 | CCL17 | 6361 | 3 | 5 | 35 | |
| GSE46452 | CCL17 | 6361 | 38 | 1 | 20 | |
| GSE47630 | CCL17 | 6361 | 10 | 8 | 22 | |
| GSE54993 | CCL17 | 6361 | 2 | 4 | 64 | |
| GSE54994 | CCL17 | 6361 | 7 | 10 | 36 | |
| GSE60625 | CCL17 | 6361 | 4 | 0 | 7 | |
| GSE74703 | CCL17 | 6361 | 3 | 3 | 30 | |
| GSE74704 | CCL17 | 6361 | 5 | 0 | 15 | |
| TCGA | CCL17 | 6361 | 26 | 12 | 58 |
Total number of gains: 110; Total number of losses: 44; Total Number of normals: 334.
Somatic mutations of CCL17:
Generating mutation plots.
Highly correlated genes for CCL17:
Showing top 20/468 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL17 | KRT74 | 0.768803 | 3 | 0 | 3 |
| CCL17 | PPM1J | 0.743166 | 3 | 0 | 3 |
| CCL17 | CCDC61 | 0.706574 | 3 | 0 | 3 |
| CCL17 | ASB10 | 0.698474 | 3 | 0 | 3 |
| CCL17 | CYP4F22 | 0.684863 | 3 | 0 | 3 |
| CCL17 | DRD2 | 0.684578 | 4 | 0 | 4 |
| CCL17 | OR2C1 | 0.679389 | 4 | 0 | 3 |
| CCL17 | TMEM184A | 0.676131 | 4 | 0 | 3 |
| CCL17 | GALNT5 | 0.67408 | 3 | 0 | 3 |
| CCL17 | CLDN9 | 0.67236 | 4 | 0 | 4 |
| CCL17 | SEC14L3 | 0.668107 | 4 | 0 | 3 |
| CCL17 | NOXA1 | 0.665105 | 4 | 0 | 4 |
| CCL17 | DIO2 | 0.664968 | 8 | 0 | 8 |
| CCL17 | DUOXA2 | 0.653561 | 3 | 0 | 3 |
| CCL17 | SLC22A7 | 0.651921 | 4 | 0 | 3 |
| CCL17 | ADORA3 | 0.651919 | 3 | 0 | 3 |
| CCL17 | CYP2D6 | 0.651809 | 4 | 0 | 3 |
| CCL17 | DAO | 0.650123 | 3 | 0 | 3 |
| CCL17 | RS1 | 0.649468 | 6 | 0 | 5 |
| CCL17 | SPNS3 | 0.648641 | 5 | 0 | 4 |
For details and further investigation, click here
