| Full name: keratin 8 | Alias Symbol: CARD2|K8|CK8|CYK8|K2C8|KO | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3856 | HGNC ID: HGNC:6446 | Ensembl Gene: ENSG00000170421 | OMIM ID: 148060 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KRT8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT8 | 3856 | 209008_x_at | 0.8501 | 0.6143 | |
| GSE20347 | KRT8 | 3856 | 209008_x_at | 1.4674 | 0.0002 | |
| GSE23400 | KRT8 | 3856 | 209008_x_at | 0.7973 | 0.0000 | |
| GSE26886 | KRT8 | 3856 | 209008_x_at | 1.0072 | 0.0064 | |
| GSE29001 | KRT8 | 3856 | 209008_x_at | 0.9239 | 0.0520 | |
| GSE38129 | KRT8 | 3856 | 209008_x_at | 1.2718 | 0.0008 | |
| GSE45670 | KRT8 | 3856 | 209008_x_at | 1.0190 | 0.0351 | |
| GSE53622 | KRT8 | 3856 | 21467 | 1.0986 | 0.0000 | |
| GSE53624 | KRT8 | 3856 | 21467 | 1.2513 | 0.0000 | |
| GSE63941 | KRT8 | 3856 | 209008_x_at | 4.5046 | 0.0011 | |
| GSE77861 | KRT8 | 3856 | 209008_x_at | 0.9816 | 0.0988 | |
| GSE97050 | KRT8 | 3856 | A_33_P3372368 | 0.6649 | 0.2268 | |
| SRP007169 | KRT8 | 3856 | RNAseq | 3.1369 | 0.0000 | |
| SRP008496 | KRT8 | 3856 | RNAseq | 2.8687 | 0.0000 | |
| SRP064894 | KRT8 | 3856 | RNAseq | 0.9556 | 0.0229 | |
| SRP133303 | KRT8 | 3856 | RNAseq | 2.2446 | 0.0001 | |
| SRP159526 | KRT8 | 3856 | RNAseq | 3.1828 | 0.0000 | |
| SRP193095 | KRT8 | 3856 | RNAseq | -0.7113 | 0.2053 | |
| SRP219564 | KRT8 | 3856 | RNAseq | 1.8502 | 0.0107 | |
| TCGA | KRT8 | 3856 | RNAseq | -0.2730 | 0.1035 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by KRT8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT8 | 3856 | 8 | 1 | 21 | |
| GSE20123 | KRT8 | 3856 | 8 | 1 | 21 | |
| GSE43470 | KRT8 | 3856 | 3 | 0 | 40 | |
| GSE46452 | KRT8 | 3856 | 7 | 1 | 51 | |
| GSE47630 | KRT8 | 3856 | 10 | 2 | 28 | |
| GSE54993 | KRT8 | 3856 | 0 | 5 | 65 | |
| GSE54994 | KRT8 | 3856 | 4 | 1 | 48 | |
| GSE60625 | KRT8 | 3856 | 0 | 0 | 11 | |
| GSE74703 | KRT8 | 3856 | 3 | 0 | 33 | |
| GSE74704 | KRT8 | 3856 | 5 | 1 | 14 | |
| TCGA | KRT8 | 3856 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of KRT8:
Generating mutation plots.
Highly correlated genes for KRT8:
Showing top 20/641 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT8 | PLEKHH1 | 0.745872 | 3 | 0 | 3 |
| KRT8 | KRT18 | 0.687313 | 10 | 0 | 9 |
| KRT8 | MIF | 0.686252 | 3 | 0 | 3 |
| KRT8 | IMMP1L | 0.677828 | 3 | 0 | 3 |
| KRT8 | PDE4D | 0.671554 | 3 | 0 | 3 |
| KRT8 | TCF20 | 0.66717 | 3 | 0 | 3 |
| KRT8 | OSR2 | 0.662681 | 5 | 0 | 4 |
| KRT8 | SLC25A5 | 0.662369 | 4 | 0 | 3 |
| KRT8 | RCC1 | 0.659572 | 6 | 0 | 5 |
| KRT8 | ARMC6 | 0.659275 | 4 | 0 | 4 |
| KRT8 | ZNRF3 | 0.658712 | 4 | 0 | 4 |
| KRT8 | LAMTOR4 | 0.654616 | 6 | 0 | 6 |
| KRT8 | CDCA7 | 0.650507 | 4 | 0 | 3 |
| KRT8 | ZNF670 | 0.64961 | 5 | 0 | 4 |
| KRT8 | KCNE3 | 0.649491 | 4 | 0 | 3 |
| KRT8 | ZNF652 | 0.649197 | 3 | 0 | 3 |
| KRT8 | SYK | 0.648595 | 3 | 0 | 3 |
| KRT8 | TMEM216 | 0.648181 | 4 | 0 | 3 |
| KRT8 | CRNKL1 | 0.647907 | 3 | 0 | 3 |
| KRT8 | ZNF512 | 0.646434 | 4 | 0 | 4 |
For details and further investigation, click here
