SYK

 

Full name: spleen associated tyrosine kinase Alias Symbol: 
Type: protein-coding gene Cytoband: 9q22.2
Entrez ID: 6850 HGNC ID: HGNC:11491 Ensembl Gene: ENSG00000165025 OMIM ID: 600085
Drug and gene relationship at DGIdb

 

SYK involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04380Osteoclast differentiation
hsa04611Platelet activation
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa05152Tuberculosis
hsa05169Epstein-Barr virus infection

 

Expression of SYK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SYK 6850 207540_s_at 0.1370 0.8423
GSE20347 SYK 6850 207540_s_at -0.1621 0.4011
GSE23400 SYK 6850 207540_s_at 0.1987 0.1198
GSE26886 SYK 6850 207540_s_at -0.8982 0.0001
GSE29001 SYK 6850 207540_s_at 0.1962 0.5542
GSE38129 SYK 6850 207540_s_at 0.2513 0.2794
GSE45670 SYK 6850 226068_at -0.0155 0.9509
GSE53622 SYK 6850 57527 -0.3889 0.0054
GSE53624 SYK 6850 90115 -0.3406 0.0000
GSE63941 SYK 6850 207540_s_at 2.6928 0.0188
GSE77861 SYK 6850 207540_s_at 0.4536 0.1013
GSE97050 SYK 6850 A_23_P9255 0.3475 0.5004
SRP007169 SYK 6850 RNAseq 0.5884 0.2458
SRP008496 SYK 6850 RNAseq 0.2910 0.3630
SRP064894 SYK 6850 RNAseq 0.1871 0.4400
SRP133303 SYK 6850 RNAseq -0.2223 0.3207
SRP159526 SYK 6850 RNAseq -0.3989 0.4688
SRP193095 SYK 6850 RNAseq -0.1495 0.3083
SRP219564 SYK 6850 RNAseq -0.0315 0.9511
TCGA SYK 6850 RNAseq 0.1993 0.0529

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by SYK expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SYK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SYK 6850 6 10 14
GSE20123 SYK 6850 6 10 14
GSE43470 SYK 6850 6 3 34
GSE46452 SYK 6850 6 14 39
GSE47630 SYK 6850 1 18 21
GSE54993 SYK 6850 4 2 64
GSE54994 SYK 6850 7 11 35
GSE60625 SYK 6850 0 0 11
GSE74703 SYK 6850 5 3 28
GSE74704 SYK 6850 3 7 10
TCGA SYK 6850 21 25 50

Total number of gains: 65; Total number of losses: 103; Total Number of normals: 320.  

 

Somatic mutations of SYK:

 

Generating mutation plots.

 

Highly correlated genes for SYK:

 

Showing top 20/371 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SYKELAVL10.792004303
SYKACTR20.78803303
SYKB3GNT70.729296303
SYKTFAP2A0.714753303
SYKNRM0.712919303
SYKBROX0.711556404
SYKMETTL170.711253303
SYKTBC1D40.704588303
SYKKIAA15220.703047505
SYKCELSR20.701922504
SYKRETSAT0.699187303
SYKTFDP10.697893303
SYKGLUD20.697499303
SYKZBED40.697412403
SYKSIAE0.695695404
SYKFAM192A0.685382404
SYKMRPL420.684881303
SYKCARHSP10.684146303
SYKTMEM1170.683771403
SYKNIT10.682441303

For details and further investigation, click here