RCC1

 

Full name: regulator of chromosome condensation 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 1p35.3
Entrez ID: 1104 HGNC ID: HGNC:1913 Ensembl Gene: ENSG00000180198 OMIM ID: 179710
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RCC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RCC1 1104 206499_s_at 0.4705 0.2729
GSE20347 RCC1 1104 206499_s_at 0.0419 0.8075
GSE23400 RCC1 1104 215747_s_at 0.1380 0.0061
GSE26886 RCC1 1104 206499_s_at 0.1944 0.2733
GSE29001 RCC1 1104 206499_s_at 0.3599 0.1189
GSE38129 RCC1 1104 206499_s_at 0.4825 0.0047
GSE45670 RCC1 1104 206499_s_at 0.7065 0.0000
GSE53622 RCC1 1104 3438 0.8470 0.0000
GSE53624 RCC1 1104 3438 0.8960 0.0000
GSE63941 RCC1 1104 206499_s_at 2.2477 0.0001
GSE77861 RCC1 1104 206499_s_at 0.2249 0.2070
GSE97050 RCC1 1104 A_23_P46309 1.0252 0.1090
SRP007169 RCC1 1104 RNAseq 1.5380 0.0041
SRP008496 RCC1 1104 RNAseq 1.1870 0.0083
SRP064894 RCC1 1104 RNAseq 0.6322 0.0042
SRP133303 RCC1 1104 RNAseq 0.7871 0.0005
SRP159526 RCC1 1104 RNAseq 0.3369 0.3462
SRP193095 RCC1 1104 RNAseq 0.1681 0.1557
SRP219564 RCC1 1104 RNAseq 0.5052 0.2219
TCGA RCC1 1104 RNAseq 0.8988 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by RCC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RCC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RCC1 1104 0 6 24
GSE20123 RCC1 1104 0 5 25
GSE43470 RCC1 1104 3 6 34
GSE46452 RCC1 1104 5 1 53
GSE47630 RCC1 1104 8 3 29
GSE54993 RCC1 1104 2 1 67
GSE54994 RCC1 1104 10 4 39
GSE60625 RCC1 1104 0 0 11
GSE74703 RCC1 1104 2 4 30
GSE74704 RCC1 1104 0 0 20
TCGA RCC1 1104 11 22 63

Total number of gains: 41; Total number of losses: 52; Total Number of normals: 395.  

 

Somatic mutations of RCC1:

 

Generating mutation plots.

 

Highly correlated genes for RCC1:

 

Showing top 20/1326 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RCC1ALG100.814509303
RCC1FANCD20.793183505
RCC1IQGAP30.792056505
RCC1RHBDF20.765555404
RCC1NACC10.764277303
RCC1ESCO20.760041707
RCC1INTS100.758521303
RCC1E2F20.745542504
RCC1TRAF70.743273404
RCC1DOCK60.742069303
RCC1EBNA1BP20.735532303
RCC1SORD0.73192404
RCC1C10orf550.731649303
RCC1EME10.730471505
RCC1PSMG30.728902605
RCC1UBE2T0.725479707
RCC1DKC10.71438303
RCC1FIGNL10.714279505
RCC1CCNB20.712599908
RCC1CDCA70.712532504

For details and further investigation, click here