PDE4D

 

Full name: phosphodiesterase 4D Alias Symbol: 
Type: protein-coding gene Cytoband: 5q11.2-q12.1
Entrez ID: 5144 HGNC ID: HGNC:8783 Ensembl Gene: ENSG00000113448 OMIM ID: 600129
Drug and gene relationship at DGIdb

 

PDE4D involved pathways:

KEGG pathway Description View
hsa04024cAMP signaling pathway

 

Expression of PDE4D:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDE4D 5144 204491_at -0.5714 0.2077
GSE20347 PDE4D 5144 204491_at -0.1125 0.5466
GSE23400 PDE4D 5144 204491_at -0.0556 0.4961
GSE26886 PDE4D 5144 204491_at 0.9734 0.0000
GSE29001 PDE4D 5144 204491_at 0.1754 0.3810
GSE38129 PDE4D 5144 204491_at -0.3614 0.0943
GSE45670 PDE4D 5144 204491_at -0.8267 0.0042
GSE53622 PDE4D 5144 127256 -0.8164 0.0000
GSE53624 PDE4D 5144 67237 -0.3613 0.0000
GSE63941 PDE4D 5144 204491_at -1.8564 0.0304
GSE77861 PDE4D 5144 204491_at 0.4829 0.0201
GSE97050 PDE4D 5144 A_33_P3389649 0.5317 0.2252
SRP007169 PDE4D 5144 RNAseq 0.6163 0.3070
SRP008496 PDE4D 5144 RNAseq 0.6607 0.0939
SRP064894 PDE4D 5144 RNAseq -0.0609 0.8035
SRP133303 PDE4D 5144 RNAseq -0.1686 0.4611
SRP159526 PDE4D 5144 RNAseq -0.2114 0.6665
SRP193095 PDE4D 5144 RNAseq -0.1371 0.5155
SRP219564 PDE4D 5144 RNAseq 1.9417 0.0043
TCGA PDE4D 5144 RNAseq -0.5128 0.0000

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by PDE4D expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDE4D:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDE4D 5144 0 13 17
GSE20123 PDE4D 5144 0 13 17
GSE43470 PDE4D 5144 1 12 30
GSE46452 PDE4D 5144 0 28 31
GSE47630 PDE4D 5144 2 17 21
GSE54993 PDE4D 5144 8 1 61
GSE54994 PDE4D 5144 2 19 32
GSE60625 PDE4D 5144 0 0 11
GSE74703 PDE4D 5144 1 9 26
GSE74704 PDE4D 5144 0 6 14
TCGA PDE4D 5144 6 52 38

Total number of gains: 20; Total number of losses: 170; Total Number of normals: 298.  

 

Somatic mutations of PDE4D:

 

Generating mutation plots.

 

Highly correlated genes for PDE4D:

 

Showing top 20/324 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDE4DMSRB30.711317303
PDE4DC3orf700.703875404
PDE4DFAXC0.693618505
PDE4DNR2F1-AS10.6909505
PDE4DHSPB60.686334404
PDE4DGSTA30.676987303
PDE4DKCNS30.676399303
PDE4DPDLIM30.674681808
PDE4DHSPB70.674405605
PDE4DKRT80.671554303
PDE4DNIPA20.669703303
PDE4DKLHL410.667091303
PDE4DPARVA0.666159807
PDE4DLPP0.663833807
PDE4DPNMA20.663142403
PDE4DAFF20.661643303
PDE4DMAP1B0.653763807
PDE4DFHL10.648288706
PDE4DDIXDC10.648135706
PDE4DAOC30.647621707

For details and further investigation, click here