| Full name: keratin 18 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3875 | HGNC ID: HGNC:6430 | Ensembl Gene: ENSG00000111057 | OMIM ID: 148070 |
| Drug and gene relationship at DGIdb | |||
Expression of KRT18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT18 | 3875 | 201596_x_at | 0.0689 | 0.9135 | |
| GSE20347 | KRT18 | 3875 | 201596_x_at | 0.0648 | 0.8578 | |
| GSE23400 | KRT18 | 3875 | 201596_x_at | 0.3858 | 0.0266 | |
| GSE26886 | KRT18 | 3875 | 201596_x_at | 0.8465 | 0.0036 | |
| GSE29001 | KRT18 | 3875 | 201596_x_at | -0.4210 | 0.5080 | |
| GSE38129 | KRT18 | 3875 | 201596_x_at | 0.6590 | 0.0288 | |
| GSE45670 | KRT18 | 3875 | 201596_x_at | 0.1546 | 0.6409 | |
| GSE63941 | KRT18 | 3875 | 201596_x_at | 4.9755 | 0.0000 | |
| GSE77861 | KRT18 | 3875 | 201596_x_at | 0.7072 | 0.1446 | |
| GSE97050 | KRT18 | 3875 | A_32_P151544 | 0.4883 | 0.3542 | |
| SRP007169 | KRT18 | 3875 | RNAseq | 0.5296 | 0.3498 | |
| SRP008496 | KRT18 | 3875 | RNAseq | 0.3375 | 0.4631 | |
| SRP064894 | KRT18 | 3875 | RNAseq | -0.6960 | 0.0711 | |
| SRP133303 | KRT18 | 3875 | RNAseq | 0.5971 | 0.1754 | |
| SRP159526 | KRT18 | 3875 | RNAseq | 1.0356 | 0.0000 | |
| SRP193095 | KRT18 | 3875 | RNAseq | -0.2389 | 0.4587 | |
| SRP219564 | KRT18 | 3875 | RNAseq | 1.1019 | 0.1404 | |
| TCGA | KRT18 | 3875 | RNAseq | -0.0671 | 0.5162 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KRT18 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KRT18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT18 | 3875 | 8 | 1 | 21 | |
| GSE20123 | KRT18 | 3875 | 8 | 1 | 21 | |
| GSE43470 | KRT18 | 3875 | 3 | 0 | 40 | |
| GSE46452 | KRT18 | 3875 | 7 | 1 | 51 | |
| GSE47630 | KRT18 | 3875 | 10 | 2 | 28 | |
| GSE54993 | KRT18 | 3875 | 0 | 5 | 65 | |
| GSE54994 | KRT18 | 3875 | 4 | 1 | 48 | |
| GSE60625 | KRT18 | 3875 | 0 | 0 | 11 | |
| GSE74703 | KRT18 | 3875 | 3 | 0 | 33 | |
| GSE74704 | KRT18 | 3875 | 5 | 1 | 14 | |
| TCGA | KRT18 | 3875 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of KRT18:
Generating mutation plots.
Highly correlated genes for KRT18:
Showing top 20/576 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT18 | ESCO2 | 0.758612 | 3 | 0 | 3 |
| KRT18 | CDCA7 | 0.755793 | 3 | 0 | 3 |
| KRT18 | APOBEC3G | 0.746697 | 3 | 0 | 3 |
| KRT18 | C1orf56 | 0.744603 | 3 | 0 | 3 |
| KRT18 | RHPN2 | 0.741116 | 4 | 0 | 3 |
| KRT18 | GALNT3 | 0.734189 | 3 | 0 | 3 |
| KRT18 | TSTD1 | 0.733887 | 3 | 0 | 3 |
| KRT18 | TMEM216 | 0.72822 | 3 | 0 | 3 |
| KRT18 | TIGD2 | 0.723248 | 3 | 0 | 3 |
| KRT18 | TEX9 | 0.718911 | 3 | 0 | 3 |
| KRT18 | TAF2 | 0.702251 | 3 | 0 | 3 |
| KRT18 | SORL1 | 0.698169 | 4 | 0 | 4 |
| KRT18 | RPS5 | 0.696808 | 3 | 0 | 3 |
| KRT18 | HOXB7 | 0.693523 | 4 | 0 | 3 |
| KRT18 | CLN6 | 0.692137 | 3 | 0 | 3 |
| KRT18 | RCC2 | 0.688949 | 4 | 0 | 4 |
| KRT18 | KRT8 | 0.687313 | 10 | 0 | 9 |
| KRT18 | SLC39A10 | 0.687312 | 3 | 0 | 3 |
| KRT18 | UBE2J2 | 0.686142 | 3 | 0 | 3 |
| KRT18 | C20orf27 | 0.685748 | 3 | 0 | 3 |
For details and further investigation, click here
