| Full name: kynureninase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q22.2 | ||
| Entrez ID: 8942 | HGNC ID: HGNC:6469 | Ensembl Gene: ENSG00000115919 | OMIM ID: 605197 |
| Drug and gene relationship at DGIdb | |||
Expression of KYNU:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KYNU | 8942 | 217388_s_at | 1.3795 | 0.4400 | |
| GSE20347 | KYNU | 8942 | 217388_s_at | 0.6092 | 0.3211 | |
| GSE23400 | KYNU | 8942 | 204385_at | 0.1994 | 0.0157 | |
| GSE26886 | KYNU | 8942 | 217388_s_at | -0.9809 | 0.1851 | |
| GSE29001 | KYNU | 8942 | 217388_s_at | 0.2183 | 0.8238 | |
| GSE38129 | KYNU | 8942 | 217388_s_at | 1.0612 | 0.0184 | |
| GSE45670 | KYNU | 8942 | 217388_s_at | 2.0576 | 0.0002 | |
| GSE53622 | KYNU | 8942 | 18757 | 1.1475 | 0.0000 | |
| GSE53624 | KYNU | 8942 | 18757 | 0.3838 | 0.0673 | |
| GSE63941 | KYNU | 8942 | 210663_s_at | -0.4113 | 0.8652 | |
| GSE77861 | KYNU | 8942 | 204385_at | 0.0788 | 0.8752 | |
| GSE97050 | KYNU | 8942 | A_24_P11506 | 1.0484 | 0.1627 | |
| SRP007169 | KYNU | 8942 | RNAseq | -0.5428 | 0.4080 | |
| SRP008496 | KYNU | 8942 | RNAseq | 0.0557 | 0.9515 | |
| SRP064894 | KYNU | 8942 | RNAseq | 1.2165 | 0.0030 | |
| SRP133303 | KYNU | 8942 | RNAseq | 0.8115 | 0.0009 | |
| SRP159526 | KYNU | 8942 | RNAseq | 1.2925 | 0.1177 | |
| SRP193095 | KYNU | 8942 | RNAseq | 1.6570 | 0.0000 | |
| SRP219564 | KYNU | 8942 | RNAseq | 1.6413 | 0.0002 | |
| TCGA | KYNU | 8942 | RNAseq | 1.4896 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by KYNU expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KYNU:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KYNU | 8942 | 4 | 4 | 22 | |
| GSE20123 | KYNU | 8942 | 3 | 4 | 23 | |
| GSE43470 | KYNU | 8942 | 3 | 1 | 39 | |
| GSE46452 | KYNU | 8942 | 1 | 4 | 54 | |
| GSE47630 | KYNU | 8942 | 5 | 3 | 32 | |
| GSE54993 | KYNU | 8942 | 0 | 5 | 65 | |
| GSE54994 | KYNU | 8942 | 10 | 2 | 41 | |
| GSE60625 | KYNU | 8942 | 0 | 3 | 8 | |
| GSE74703 | KYNU | 8942 | 2 | 1 | 33 | |
| GSE74704 | KYNU | 8942 | 3 | 2 | 15 | |
| TCGA | KYNU | 8942 | 22 | 12 | 62 |
Total number of gains: 53; Total number of losses: 41; Total Number of normals: 394.
Somatic mutations of KYNU:
Generating mutation plots.
Highly correlated genes for KYNU:
Showing top 20/346 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KYNU | SUSD1 | 0.711808 | 3 | 0 | 3 |
| KYNU | NUS1 | 0.673443 | 3 | 0 | 3 |
| KYNU | ALDH7A1 | 0.664307 | 3 | 0 | 3 |
| KYNU | FAF2 | 0.663657 | 3 | 0 | 3 |
| KYNU | MET | 0.663642 | 4 | 0 | 3 |
| KYNU | IQGAP3 | 0.658682 | 3 | 0 | 3 |
| KYNU | RDH11 | 0.656419 | 4 | 0 | 4 |
| KYNU | SLC26A9 | 0.651397 | 3 | 0 | 3 |
| KYNU | COL17A1 | 0.649285 | 3 | 0 | 3 |
| KYNU | SERBP1 | 0.649231 | 3 | 0 | 3 |
| KYNU | TMEM167A | 0.649052 | 4 | 0 | 3 |
| KYNU | STK35 | 0.647363 | 3 | 0 | 3 |
| KYNU | RBM45 | 0.644592 | 3 | 0 | 3 |
| KYNU | ANLN | 0.644332 | 4 | 0 | 3 |
| KYNU | CDCA2 | 0.642733 | 3 | 0 | 3 |
| KYNU | ALG10 | 0.641852 | 3 | 0 | 3 |
| KYNU | C9orf40 | 0.640455 | 3 | 0 | 3 |
| KYNU | OCIAD2 | 0.64014 | 4 | 0 | 3 |
| KYNU | SLC30A7 | 0.63767 | 3 | 0 | 3 |
| KYNU | TRMT61B | 0.635291 | 3 | 0 | 3 |
For details and further investigation, click here
