| Full name: IQ motif containing GTPase activating protein 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 128239 | HGNC ID: HGNC:20669 | Ensembl Gene: ENSG00000183856 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
IQGAP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of IQGAP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IQGAP3 | 128239 | 241939_at | 0.0071 | 0.9846 | |
| GSE26886 | IQGAP3 | 128239 | 229538_s_at | 0.3139 | 0.4482 | |
| GSE45670 | IQGAP3 | 128239 | 229538_s_at | 1.2812 | 0.0000 | |
| GSE53622 | IQGAP3 | 128239 | 29128 | 1.1053 | 0.0000 | |
| GSE53624 | IQGAP3 | 128239 | 29128 | 1.4681 | 0.0000 | |
| GSE63941 | IQGAP3 | 128239 | 229538_s_at | 2.5983 | 0.0005 | |
| GSE77861 | IQGAP3 | 128239 | 241939_at | -0.2289 | 0.0291 | |
| GSE97050 | IQGAP3 | 128239 | A_33_P3321293 | 0.9375 | 0.1298 | |
| SRP007169 | IQGAP3 | 128239 | RNAseq | 2.1663 | 0.0000 | |
| SRP008496 | IQGAP3 | 128239 | RNAseq | 1.5197 | 0.0004 | |
| SRP064894 | IQGAP3 | 128239 | RNAseq | 2.0183 | 0.0000 | |
| SRP133303 | IQGAP3 | 128239 | RNAseq | 1.7075 | 0.0000 | |
| SRP159526 | IQGAP3 | 128239 | RNAseq | 1.8848 | 0.0002 | |
| SRP193095 | IQGAP3 | 128239 | RNAseq | 1.3159 | 0.0000 | |
| SRP219564 | IQGAP3 | 128239 | RNAseq | 1.7104 | 0.0233 | |
| TCGA | IQGAP3 | 128239 | RNAseq | 0.9206 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by IQGAP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IQGAP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IQGAP3 | 128239 | 12 | 0 | 18 | |
| GSE20123 | IQGAP3 | 128239 | 12 | 0 | 18 | |
| GSE43470 | IQGAP3 | 128239 | 7 | 2 | 34 | |
| GSE46452 | IQGAP3 | 128239 | 2 | 1 | 56 | |
| GSE47630 | IQGAP3 | 128239 | 14 | 0 | 26 | |
| GSE54993 | IQGAP3 | 128239 | 0 | 5 | 65 | |
| GSE54994 | IQGAP3 | 128239 | 16 | 0 | 37 | |
| GSE60625 | IQGAP3 | 128239 | 0 | 0 | 11 | |
| GSE74703 | IQGAP3 | 128239 | 7 | 2 | 27 | |
| GSE74704 | IQGAP3 | 128239 | 6 | 0 | 14 | |
| TCGA | IQGAP3 | 128239 | 38 | 2 | 56 |
Total number of gains: 114; Total number of losses: 12; Total Number of normals: 362.
Somatic mutations of IQGAP3:
Generating mutation plots.
Highly correlated genes for IQGAP3:
Showing top 20/272 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IQGAP3 | CENPO | 0.798614 | 4 | 0 | 4 |
| IQGAP3 | RCC1 | 0.792056 | 5 | 0 | 5 |
| IQGAP3 | CEP85 | 0.786832 | 5 | 0 | 5 |
| IQGAP3 | ESCO2 | 0.784893 | 5 | 0 | 5 |
| IQGAP3 | SPC24 | 0.784047 | 6 | 0 | 6 |
| IQGAP3 | GINS4 | 0.78335 | 3 | 0 | 3 |
| IQGAP3 | CCNF | 0.763373 | 6 | 0 | 6 |
| IQGAP3 | DKC1 | 0.735419 | 3 | 0 | 3 |
| IQGAP3 | ORC1 | 0.73234 | 5 | 0 | 5 |
| IQGAP3 | C17orf53 | 0.732266 | 5 | 0 | 5 |
| IQGAP3 | ASF1B | 0.731799 | 5 | 0 | 5 |
| IQGAP3 | PAQR4 | 0.728032 | 5 | 0 | 5 |
| IQGAP3 | KIF20B | 0.717857 | 6 | 0 | 6 |
| IQGAP3 | CENPA | 0.71514 | 6 | 0 | 5 |
| IQGAP3 | NDOR1 | 0.708371 | 5 | 0 | 4 |
| IQGAP3 | DIAPH1 | 0.706818 | 3 | 0 | 3 |
| IQGAP3 | PKMYT1 | 0.705595 | 4 | 0 | 3 |
| IQGAP3 | LMNB1 | 0.70361 | 6 | 0 | 6 |
| IQGAP3 | TONSL | 0.703384 | 3 | 0 | 3 |
| IQGAP3 | ZIC5 | 0.702099 | 3 | 0 | 3 |
For details and further investigation, click here
