| Full name: aldehyde dehydrogenase 7 family member A1 | Alias Symbol: EPD|PDE | ||
| Type: protein-coding gene | Cytoband: 5q23.2 | ||
| Entrez ID: 501 | HGNC ID: HGNC:877 | Ensembl Gene: ENSG00000164904 | OMIM ID: 107323 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH7A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH7A1 | 501 | 208950_s_at | -0.1795 | 0.8906 | |
| GSE20347 | ALDH7A1 | 501 | 208950_s_at | -1.0110 | 0.0004 | |
| GSE23400 | ALDH7A1 | 501 | 208950_s_at | -0.7648 | 0.0000 | |
| GSE26886 | ALDH7A1 | 501 | 208950_s_at | -1.6600 | 0.0167 | |
| GSE29001 | ALDH7A1 | 501 | 208950_s_at | -0.8828 | 0.0511 | |
| GSE38129 | ALDH7A1 | 501 | 208950_s_at | -1.0121 | 0.0009 | |
| GSE45670 | ALDH7A1 | 501 | 208950_s_at | -0.4240 | 0.4020 | |
| GSE53622 | ALDH7A1 | 501 | 59537 | -1.1043 | 0.0000 | |
| GSE53624 | ALDH7A1 | 501 | 59537 | -1.0559 | 0.0000 | |
| GSE63941 | ALDH7A1 | 501 | 208950_s_at | -1.5611 | 0.4263 | |
| GSE77861 | ALDH7A1 | 501 | 208950_s_at | -1.3681 | 0.0179 | |
| GSE97050 | ALDH7A1 | 501 | A_23_P70231 | -0.1045 | 0.6894 | |
| SRP007169 | ALDH7A1 | 501 | RNAseq | -0.5389 | 0.1978 | |
| SRP008496 | ALDH7A1 | 501 | RNAseq | -1.3400 | 0.0104 | |
| SRP064894 | ALDH7A1 | 501 | RNAseq | -0.3702 | 0.0507 | |
| SRP133303 | ALDH7A1 | 501 | RNAseq | -0.8714 | 0.0293 | |
| SRP159526 | ALDH7A1 | 501 | RNAseq | -1.7408 | 0.0081 | |
| SRP193095 | ALDH7A1 | 501 | RNAseq | -1.2150 | 0.0000 | |
| SRP219564 | ALDH7A1 | 501 | RNAseq | -1.5530 | 0.0001 | |
| TCGA | ALDH7A1 | 501 | RNAseq | -0.1789 | 0.2303 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by ALDH7A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH7A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH7A1 | 501 | 1 | 12 | 17 | |
| GSE20123 | ALDH7A1 | 501 | 1 | 12 | 17 | |
| GSE43470 | ALDH7A1 | 501 | 3 | 8 | 32 | |
| GSE46452 | ALDH7A1 | 501 | 0 | 27 | 32 | |
| GSE47630 | ALDH7A1 | 501 | 0 | 21 | 19 | |
| GSE54993 | ALDH7A1 | 501 | 9 | 1 | 60 | |
| GSE54994 | ALDH7A1 | 501 | 2 | 14 | 37 | |
| GSE60625 | ALDH7A1 | 501 | 0 | 0 | 11 | |
| GSE74703 | ALDH7A1 | 501 | 2 | 6 | 28 | |
| GSE74704 | ALDH7A1 | 501 | 1 | 6 | 13 | |
| TCGA | ALDH7A1 | 501 | 2 | 40 | 54 |
Total number of gains: 21; Total number of losses: 147; Total Number of normals: 320.
Somatic mutations of ALDH7A1:
Generating mutation plots.
Highly correlated genes for ALDH7A1:
Showing top 20/588 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH7A1 | VTI1B | 0.767719 | 3 | 0 | 3 |
| ALDH7A1 | TBC1D20 | 0.740458 | 3 | 0 | 3 |
| ALDH7A1 | GFM2 | 0.73794 | 3 | 0 | 3 |
| ALDH7A1 | ZNF304 | 0.726219 | 3 | 0 | 3 |
| ALDH7A1 | ROBO1 | 0.722719 | 3 | 0 | 3 |
| ALDH7A1 | C1orf56 | 0.720252 | 3 | 0 | 3 |
| ALDH7A1 | FYTTD1 | 0.71501 | 3 | 0 | 3 |
| ALDH7A1 | CD47 | 0.713094 | 4 | 0 | 3 |
| ALDH7A1 | NSFL1C | 0.70977 | 4 | 0 | 4 |
| ALDH7A1 | DUSP18 | 0.707599 | 3 | 0 | 3 |
| ALDH7A1 | COMMD9 | 0.707078 | 3 | 0 | 3 |
| ALDH7A1 | RWDD4 | 0.707022 | 3 | 0 | 3 |
| ALDH7A1 | RPL27A | 0.702481 | 4 | 0 | 4 |
| ALDH7A1 | B4GALT5 | 0.700305 | 4 | 0 | 4 |
| ALDH7A1 | AMPD3 | 0.6999 | 3 | 0 | 3 |
| ALDH7A1 | ATG2B | 0.697123 | 3 | 0 | 3 |
| ALDH7A1 | ZNF436 | 0.697011 | 4 | 0 | 3 |
| ALDH7A1 | NEDD8 | 0.695476 | 4 | 0 | 3 |
| ALDH7A1 | DHX15 | 0.691955 | 3 | 0 | 3 |
| ALDH7A1 | GTF3C6 | 0.690646 | 4 | 0 | 3 |
For details and further investigation, click here
