| Full name: serine/threonine kinase 35 | Alias Symbol: bA550O8.2|CLIK1 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 140901 | HGNC ID: HGNC:16254 | Ensembl Gene: ENSG00000125834 | OMIM ID: 609370 |
| Drug and gene relationship at DGIdb | |||
Expression of STK35:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STK35 | 140901 | 225649_s_at | 0.3290 | 0.5377 | |
| GSE26886 | STK35 | 140901 | 225649_s_at | -0.2657 | 0.2468 | |
| GSE45670 | STK35 | 140901 | 225649_s_at | 0.1813 | 0.3641 | |
| GSE53622 | STK35 | 140901 | 6345 | 0.0721 | 0.4676 | |
| GSE53624 | STK35 | 140901 | 6345 | -0.1590 | 0.0230 | |
| GSE63941 | STK35 | 140901 | 225649_s_at | 0.3420 | 0.3598 | |
| GSE77861 | STK35 | 140901 | 225649_s_at | -0.1016 | 0.7843 | |
| GSE97050 | STK35 | 140901 | A_23_P342600 | 0.3128 | 0.5136 | |
| SRP007169 | STK35 | 140901 | RNAseq | -1.3056 | 0.0001 | |
| SRP008496 | STK35 | 140901 | RNAseq | -0.9236 | 0.0000 | |
| SRP064894 | STK35 | 140901 | RNAseq | -0.2510 | 0.1889 | |
| SRP133303 | STK35 | 140901 | RNAseq | -0.0204 | 0.9156 | |
| SRP159526 | STK35 | 140901 | RNAseq | 0.1202 | 0.6496 | |
| SRP193095 | STK35 | 140901 | RNAseq | -0.0989 | 0.4185 | |
| SRP219564 | STK35 | 140901 | RNAseq | 0.1335 | 0.7376 | |
| TCGA | STK35 | 140901 | RNAseq | -0.0025 | 0.9571 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by STK35 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STK35:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STK35 | 140901 | 12 | 3 | 15 | |
| GSE20123 | STK35 | 140901 | 13 | 3 | 14 | |
| GSE43470 | STK35 | 140901 | 11 | 1 | 31 | |
| GSE46452 | STK35 | 140901 | 26 | 1 | 32 | |
| GSE47630 | STK35 | 140901 | 18 | 4 | 18 | |
| GSE54993 | STK35 | 140901 | 2 | 14 | 54 | |
| GSE54994 | STK35 | 140901 | 24 | 2 | 27 | |
| GSE60625 | STK35 | 140901 | 0 | 0 | 11 | |
| GSE74703 | STK35 | 140901 | 10 | 1 | 25 | |
| GSE74704 | STK35 | 140901 | 8 | 1 | 11 | |
| TCGA | STK35 | 140901 | 40 | 11 | 45 |
Total number of gains: 164; Total number of losses: 41; Total Number of normals: 283.
Somatic mutations of STK35:
Generating mutation plots.
Highly correlated genes for STK35:
Showing top 20/141 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STK35 | NF2 | 0.761985 | 3 | 0 | 3 |
| STK35 | PHLPP1 | 0.738271 | 3 | 0 | 3 |
| STK35 | WDR82 | 0.735167 | 3 | 0 | 3 |
| STK35 | EIF4G2 | 0.734764 | 3 | 0 | 3 |
| STK35 | PXMP4 | 0.726753 | 3 | 0 | 3 |
| STK35 | USP10 | 0.726319 | 3 | 0 | 3 |
| STK35 | WIPI2 | 0.725443 | 3 | 0 | 3 |
| STK35 | HSPA4 | 0.709285 | 3 | 0 | 3 |
| STK35 | CSNK2A1 | 0.708722 | 7 | 0 | 6 |
| STK35 | TMEM51 | 0.699404 | 3 | 0 | 3 |
| STK35 | NSFL1C | 0.698491 | 8 | 0 | 7 |
| STK35 | ADCY7 | 0.694104 | 3 | 0 | 3 |
| STK35 | CMC1 | 0.693997 | 3 | 0 | 3 |
| STK35 | EARS2 | 0.687782 | 3 | 0 | 3 |
| STK35 | TBC1D9B | 0.687774 | 3 | 0 | 3 |
| STK35 | THAP11 | 0.687529 | 3 | 0 | 3 |
| STK35 | YWHAB | 0.677384 | 4 | 0 | 4 |
| STK35 | MAP3K5 | 0.675436 | 3 | 0 | 3 |
| STK35 | VPS16 | 0.671297 | 5 | 0 | 4 |
| STK35 | SYT7 | 0.669771 | 3 | 0 | 3 |
For details and further investigation, click here
