| Full name: SERPINE1 mRNA binding protein 1 | Alias Symbol: PAI-RBP1|DKFZP564M2423|CGI-55|HABP4L|PAIRBP1|CHD3IP | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 26135 | HGNC ID: HGNC:17860 | Ensembl Gene: ENSG00000142864 | OMIM ID: 607378 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SERBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERBP1 | 26135 | 210466_s_at | 0.0720 | 0.8744 | |
| GSE20347 | SERBP1 | 26135 | 217724_at | -0.3680 | 0.0062 | |
| GSE23400 | SERBP1 | 26135 | 217724_at | -0.0398 | 0.5873 | |
| GSE26886 | SERBP1 | 26135 | 217724_at | -0.7054 | 0.0005 | |
| GSE29001 | SERBP1 | 26135 | 209669_s_at | -0.0493 | 0.9344 | |
| GSE38129 | SERBP1 | 26135 | 217724_at | -0.2283 | 0.0601 | |
| GSE45670 | SERBP1 | 26135 | 217724_at | -0.1241 | 0.2733 | |
| GSE53622 | SERBP1 | 26135 | 58690 | -0.5171 | 0.0000 | |
| GSE53624 | SERBP1 | 26135 | 58690 | -0.4666 | 0.0000 | |
| GSE63941 | SERBP1 | 26135 | 210466_s_at | 1.0495 | 0.0002 | |
| GSE77861 | SERBP1 | 26135 | 210466_s_at | -0.1660 | 0.5293 | |
| GSE97050 | SERBP1 | 26135 | A_32_P187599 | 0.2140 | 0.6173 | |
| SRP007169 | SERBP1 | 26135 | RNAseq | 0.5821 | 0.1825 | |
| SRP008496 | SERBP1 | 26135 | RNAseq | 0.5435 | 0.0288 | |
| SRP064894 | SERBP1 | 26135 | RNAseq | -0.1147 | 0.4524 | |
| SRP133303 | SERBP1 | 26135 | RNAseq | -0.1733 | 0.1961 | |
| SRP159526 | SERBP1 | 26135 | RNAseq | -0.7961 | 0.0000 | |
| SRP193095 | SERBP1 | 26135 | RNAseq | -0.5404 | 0.0000 | |
| SRP219564 | SERBP1 | 26135 | RNAseq | -0.0699 | 0.8669 | |
| TCGA | SERBP1 | 26135 | RNAseq | 0.0628 | 0.1030 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SERBP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERBP1 | 26135 | 1 | 6 | 23 | |
| GSE20123 | SERBP1 | 26135 | 1 | 5 | 24 | |
| GSE43470 | SERBP1 | 26135 | 5 | 2 | 36 | |
| GSE46452 | SERBP1 | 26135 | 0 | 1 | 58 | |
| GSE47630 | SERBP1 | 26135 | 8 | 5 | 27 | |
| GSE54993 | SERBP1 | 26135 | 0 | 0 | 70 | |
| GSE54994 | SERBP1 | 26135 | 6 | 4 | 43 | |
| GSE60625 | SERBP1 | 26135 | 0 | 0 | 11 | |
| GSE74703 | SERBP1 | 26135 | 4 | 2 | 30 | |
| GSE74704 | SERBP1 | 26135 | 1 | 2 | 17 | |
| TCGA | SERBP1 | 26135 | 8 | 22 | 66 |
Total number of gains: 34; Total number of losses: 49; Total Number of normals: 405.
Somatic mutations of SERBP1:
Generating mutation plots.
Highly correlated genes for SERBP1:
Showing top 20/380 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERBP1 | RNF149 | 0.75881 | 3 | 0 | 3 |
| SERBP1 | SH3RF2 | 0.701804 | 3 | 0 | 3 |
| SERBP1 | FAM83A | 0.701434 | 3 | 0 | 3 |
| SERBP1 | EIF3H | 0.697364 | 3 | 0 | 3 |
| SERBP1 | PPP1R14C | 0.695892 | 3 | 0 | 3 |
| SERBP1 | GOLGA5 | 0.693317 | 4 | 0 | 3 |
| SERBP1 | MAD2L1 | 0.69217 | 3 | 0 | 3 |
| SERBP1 | BAIAP2L1 | 0.687955 | 3 | 0 | 3 |
| SERBP1 | CMTR2 | 0.676043 | 3 | 0 | 3 |
| SERBP1 | DMKN | 0.674266 | 4 | 0 | 4 |
| SERBP1 | FAM83B | 0.674148 | 3 | 0 | 3 |
| SERBP1 | TMX1 | 0.673783 | 3 | 0 | 3 |
| SERBP1 | E2F2 | 0.667321 | 3 | 0 | 3 |
| SERBP1 | PRDM2 | 0.666793 | 3 | 0 | 3 |
| SERBP1 | HMGCR | 0.662075 | 6 | 0 | 5 |
| SERBP1 | SLC25A43 | 0.65987 | 3 | 0 | 3 |
| SERBP1 | CDH1 | 0.65852 | 5 | 0 | 4 |
| SERBP1 | ATG2B | 0.6567 | 4 | 0 | 3 |
| SERBP1 | TRAPPC11 | 0.655307 | 5 | 0 | 5 |
| SERBP1 | GGCT | 0.649479 | 5 | 0 | 4 |
For details and further investigation, click here
