MET

 

Full name: MET proto-oncogene, receptor tyrosine kinase Alias Symbol: HGFR|RCCP2|DFNB97
Type: protein-coding gene Cytoband: 7q31
Entrez ID: 4233 HGNC ID: HGNC:7029 Ensembl Gene: ENSG00000105976 OMIM ID: 164860
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 13/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MET involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04520Adherens junction
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05218Melanoma

 

Expression of MET:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MET 4233 203510_at 0.7827 0.5794
GSE20347 MET 4233 203510_at 2.4146 0.0000
GSE23400 MET 4233 211599_x_at 0.2745 0.0000
GSE26886 MET 4233 203510_at 2.5551 0.0000
GSE29001 MET 4233 203510_at 2.3595 0.0000
GSE38129 MET 4233 203510_at 2.2617 0.0000
GSE45670 MET 4233 203510_at 1.8441 0.0000
GSE53622 MET 4233 110044 1.6888 0.0000
GSE53624 MET 4233 110044 2.0142 0.0000
GSE63941 MET 4233 203510_at 1.1327 0.0935
GSE77861 MET 4233 203510_at 2.2401 0.0026
GSE97050 MET 4233 A_23_P359245 1.4750 0.1057
SRP007169 MET 4233 RNAseq 2.9957 0.0000
SRP008496 MET 4233 RNAseq 2.8298 0.0000
SRP064894 MET 4233 RNAseq 1.5762 0.0000
SRP133303 MET 4233 RNAseq 1.9482 0.0000
SRP159526 MET 4233 RNAseq 1.5139 0.0003
SRP193095 MET 4233 RNAseq 1.5021 0.0000
SRP219564 MET 4233 RNAseq 1.8198 0.0060
TCGA MET 4233 RNAseq 0.1965 0.0225

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by MET expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MET:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MET 4233 9 2 19
GSE20123 MET 4233 10 2 18
GSE43470 MET 4233 3 2 38
GSE46452 MET 4233 8 1 50
GSE47630 MET 4233 7 4 29
GSE54993 MET 4233 2 7 61
GSE54994 MET 4233 11 5 37
GSE60625 MET 4233 0 0 11
GSE74703 MET 4233 3 2 31
GSE74704 MET 4233 7 2 11
TCGA MET 4233 33 18 45

Total number of gains: 93; Total number of losses: 45; Total Number of normals: 350.  

 

Somatic mutations of MET:

 

Generating mutation plots.

 

Highly correlated genes for MET:

 

Showing top 20/1960 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
METFAM89A0.832353303
METCMSS10.816474505
METFMNL20.810772707
METC12orf750.80742707
METMMP10.78934211010
METBRIX10.784736909
METSIX40.772974606
METWDR540.770595707
METZNF2810.767755909
METXPR10.766126707
METPARP120.76507510010
METDCBLD10.763613707
METCENPL0.762175606
METMMP120.75962911010
METMFHAS10.755457909
METPLAU0.7541171109
METLAPTM4B0.74921811010
METMTHFD20.74808811010
METCENPW0.74602606
METCDCA20.745946504

For details and further investigation, click here