| Full name: laminin subunit alpha 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18p11.31 | ||
| Entrez ID: 284217 | HGNC ID: HGNC:6481 | Ensembl Gene: ENSG00000101680 | OMIM ID: 150320 |
| Drug and gene relationship at DGIdb | |||
LAMA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of LAMA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMA1 | 284217 | 222346_at | 0.0260 | 0.9432 | |
| GSE20347 | LAMA1 | 284217 | 222346_at | 0.0524 | 0.5955 | |
| GSE23400 | LAMA1 | 284217 | 222346_at | -0.1137 | 0.0052 | |
| GSE26886 | LAMA1 | 284217 | 222346_at | 0.0373 | 0.7965 | |
| GSE29001 | LAMA1 | 284217 | 222346_at | 0.3436 | 0.1057 | |
| GSE38129 | LAMA1 | 284217 | 222346_at | -0.0137 | 0.9047 | |
| GSE45670 | LAMA1 | 284217 | 227048_at | 1.2099 | 0.0078 | |
| GSE53622 | LAMA1 | 284217 | 172374 | 2.3264 | 0.0000 | |
| GSE53624 | LAMA1 | 284217 | 172374 | 2.1794 | 0.0000 | |
| GSE63941 | LAMA1 | 284217 | 227048_at | -1.2430 | 0.2937 | |
| GSE77861 | LAMA1 | 284217 | 222346_at | -0.2239 | 0.0457 | |
| SRP008496 | LAMA1 | 284217 | RNAseq | 5.6108 | 0.0000 | |
| SRP133303 | LAMA1 | 284217 | RNAseq | 3.0234 | 0.0000 | |
| SRP159526 | LAMA1 | 284217 | RNAseq | 4.6864 | 0.0000 | |
| SRP219564 | LAMA1 | 284217 | RNAseq | 3.3944 | 0.0000 | |
| TCGA | LAMA1 | 284217 | RNAseq | 1.9250 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by LAMA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAMA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMA1 | 284217 | 7 | 3 | 20 | |
| GSE20123 | LAMA1 | 284217 | 7 | 3 | 20 | |
| GSE43470 | LAMA1 | 284217 | 4 | 5 | 34 | |
| GSE46452 | LAMA1 | 284217 | 3 | 21 | 35 | |
| GSE47630 | LAMA1 | 284217 | 7 | 17 | 16 | |
| GSE54993 | LAMA1 | 284217 | 6 | 3 | 61 | |
| GSE54994 | LAMA1 | 284217 | 9 | 8 | 36 | |
| GSE60625 | LAMA1 | 284217 | 0 | 4 | 7 | |
| GSE74703 | LAMA1 | 284217 | 3 | 3 | 30 | |
| GSE74704 | LAMA1 | 284217 | 5 | 2 | 13 | |
| TCGA | LAMA1 | 284217 | 33 | 20 | 43 |
Total number of gains: 84; Total number of losses: 89; Total Number of normals: 315.
Somatic mutations of LAMA1:
Generating mutation plots.
Highly correlated genes for LAMA1:
Showing top 20/167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMA1 | ZFHX2 | 0.663476 | 5 | 0 | 4 |
| LAMA1 | C9orf131 | 0.656193 | 3 | 0 | 3 |
| LAMA1 | BTNL2 | 0.652035 | 4 | 0 | 4 |
| LAMA1 | TNFRSF10C | 0.640292 | 3 | 0 | 3 |
| LAMA1 | SMIM6 | 0.634404 | 3 | 0 | 3 |
| LAMA1 | PAQR9 | 0.632404 | 3 | 0 | 3 |
| LAMA1 | SRD5A2 | 0.631445 | 5 | 0 | 5 |
| LAMA1 | GLRA2 | 0.629598 | 4 | 0 | 4 |
| LAMA1 | DGCR9 | 0.624756 | 3 | 0 | 3 |
| LAMA1 | OR2H1 | 0.613741 | 4 | 0 | 3 |
| LAMA1 | BMP15 | 0.611541 | 4 | 0 | 3 |
| LAMA1 | NANOG | 0.607784 | 3 | 0 | 3 |
| LAMA1 | CACNG8 | 0.604873 | 3 | 0 | 3 |
| LAMA1 | FAM153A | 0.602697 | 5 | 0 | 4 |
| LAMA1 | RASGEF1C | 0.602374 | 3 | 0 | 3 |
| LAMA1 | MAPRE3 | 0.601858 | 3 | 0 | 3 |
| LAMA1 | LINC00598 | 0.600751 | 3 | 0 | 3 |
| LAMA1 | CNGB1 | 0.598452 | 5 | 0 | 4 |
| LAMA1 | DNAJC22 | 0.597277 | 5 | 0 | 4 |
| LAMA1 | C3orf36 | 0.596976 | 5 | 0 | 4 |
For details and further investigation, click here
