| Full name: Nanog homeobox | Alias Symbol: FLJ12581|FLJ40451 | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 79923 | HGNC ID: HGNC:20857 | Ensembl Gene: ENSG00000111704 | OMIM ID: 607937 |
| Drug and gene relationship at DGIdb | |||
NANOG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | |
| hsa05205 | Proteoglycans in cancer |
Expression of NANOG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NANOG | 79923 | 231079_at | -0.0629 | 0.8516 | |
| GSE20347 | NANOG | 79923 | 220184_at | 0.3571 | 0.3096 | |
| GSE23400 | NANOG | 79923 | 220184_at | 0.0032 | 0.9462 | |
| GSE26886 | NANOG | 79923 | 231079_at | 0.1397 | 0.2780 | |
| GSE29001 | NANOG | 79923 | 220184_at | -0.0334 | 0.9260 | |
| GSE38129 | NANOG | 79923 | 220184_at | 0.0504 | 0.8454 | |
| GSE45670 | NANOG | 79923 | 231079_at | -0.0734 | 0.4807 | |
| GSE63941 | NANOG | 79923 | 231079_at | -0.0162 | 0.9210 | |
| GSE77861 | NANOG | 79923 | 231079_at | -0.0952 | 0.2325 | |
| GSE97050 | NANOG | 79923 | A_23_P204640 | -0.2992 | 0.3074 | |
| SRP133303 | NANOG | 79923 | RNAseq | 0.1269 | 0.4531 | |
| SRP159526 | NANOG | 79923 | RNAseq | 0.5399 | 0.3125 | |
| SRP193095 | NANOG | 79923 | RNAseq | 0.0955 | 0.6869 | |
| SRP219564 | NANOG | 79923 | RNAseq | 0.3374 | 0.5250 | |
| TCGA | NANOG | 79923 | RNAseq | -0.4016 | 0.4995 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NANOG expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NANOG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NANOG | 79923 | 6 | 3 | 21 | |
| GSE20123 | NANOG | 79923 | 6 | 3 | 21 | |
| GSE43470 | NANOG | 79923 | 7 | 3 | 33 | |
| GSE46452 | NANOG | 79923 | 10 | 1 | 48 | |
| GSE47630 | NANOG | 79923 | 12 | 2 | 26 | |
| GSE54993 | NANOG | 79923 | 1 | 10 | 59 | |
| GSE54994 | NANOG | 79923 | 9 | 5 | 39 | |
| GSE60625 | NANOG | 79923 | 0 | 1 | 10 | |
| GSE74703 | NANOG | 79923 | 7 | 2 | 27 | |
| GSE74704 | NANOG | 79923 | 4 | 2 | 14 | |
| TCGA | NANOG | 79923 | 40 | 6 | 50 |
Total number of gains: 102; Total number of losses: 38; Total Number of normals: 348.
Somatic mutations of NANOG:
Generating mutation plots.
Highly correlated genes for NANOG:
Showing top 20/230 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NANOG | AMBRA1 | 0.713565 | 3 | 0 | 3 |
| NANOG | C4BPB | 0.687365 | 5 | 0 | 4 |
| NANOG | CYP2A6 | 0.679954 | 4 | 0 | 3 |
| NANOG | LINC00313 | 0.679011 | 3 | 0 | 3 |
| NANOG | TNXB | 0.668989 | 3 | 0 | 3 |
| NANOG | BARX1 | 0.667389 | 3 | 0 | 3 |
| NANOG | C1QL1 | 0.66182 | 3 | 0 | 3 |
| NANOG | SLC1A6 | 0.659165 | 3 | 0 | 3 |
| NANOG | HTN3 | 0.655958 | 3 | 0 | 3 |
| NANOG | KRT31 | 0.655147 | 3 | 0 | 3 |
| NANOG | FEZF2 | 0.654383 | 3 | 0 | 3 |
| NANOG | SLC2A4 | 0.654284 | 3 | 0 | 3 |
| NANOG | DGCR9 | 0.650567 | 3 | 0 | 3 |
| NANOG | FUT9 | 0.649123 | 3 | 0 | 3 |
| NANOG | MAGEB3 | 0.645243 | 3 | 0 | 3 |
| NANOG | NACAD | 0.63698 | 3 | 0 | 3 |
| NANOG | OR3A2 | 0.636963 | 4 | 0 | 3 |
| NANOG | DEFA4 | 0.635315 | 5 | 0 | 4 |
| NANOG | SLC26A10 | 0.635038 | 3 | 0 | 3 |
| NANOG | ZFHX2 | 0.633663 | 6 | 0 | 5 |
For details and further investigation, click here
