| Full name: leucine rich repeat containing G protein-coupled receptor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p14.1 | ||
| Entrez ID: 55366 | HGNC ID: HGNC:13299 | Ensembl Gene: ENSG00000205213 | OMIM ID: 606666 |
| Drug and gene relationship at DGIdb | |||
Expression of LGR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGR4 | 55366 | 218326_s_at | -0.5176 | 0.3183 | |
| GSE20347 | LGR4 | 55366 | 218326_s_at | -1.2314 | 0.0000 | |
| GSE23400 | LGR4 | 55366 | 218326_s_at | -0.1718 | 0.0350 | |
| GSE26886 | LGR4 | 55366 | 218326_s_at | -0.7252 | 0.0483 | |
| GSE29001 | LGR4 | 55366 | 218326_s_at | -0.9133 | 0.0146 | |
| GSE38129 | LGR4 | 55366 | 218326_s_at | -0.8567 | 0.0003 | |
| GSE45670 | LGR4 | 55366 | 218326_s_at | -0.6072 | 0.0227 | |
| GSE53622 | LGR4 | 55366 | 57607 | -0.7451 | 0.0000 | |
| GSE53624 | LGR4 | 55366 | 57607 | -0.9554 | 0.0000 | |
| GSE63941 | LGR4 | 55366 | 218326_s_at | -0.1570 | 0.8782 | |
| GSE77861 | LGR4 | 55366 | 218326_s_at | -0.9238 | 0.0287 | |
| GSE97050 | LGR4 | 55366 | A_24_P90216 | -0.2755 | 0.2395 | |
| SRP007169 | LGR4 | 55366 | RNAseq | -0.8912 | 0.1264 | |
| SRP008496 | LGR4 | 55366 | RNAseq | -0.7799 | 0.0105 | |
| SRP064894 | LGR4 | 55366 | RNAseq | -0.9483 | 0.0156 | |
| SRP133303 | LGR4 | 55366 | RNAseq | -0.6721 | 0.0003 | |
| SRP159526 | LGR4 | 55366 | RNAseq | -0.9558 | 0.0055 | |
| SRP193095 | LGR4 | 55366 | RNAseq | -1.3018 | 0.0000 | |
| SRP219564 | LGR4 | 55366 | RNAseq | -0.4822 | 0.2139 | |
| TCGA | LGR4 | 55366 | RNAseq | -0.3799 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LGR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGR4 | 55366 | 1 | 9 | 20 | |
| GSE20123 | LGR4 | 55366 | 1 | 8 | 21 | |
| GSE43470 | LGR4 | 55366 | 1 | 5 | 37 | |
| GSE46452 | LGR4 | 55366 | 7 | 5 | 47 | |
| GSE47630 | LGR4 | 55366 | 3 | 10 | 27 | |
| GSE54993 | LGR4 | 55366 | 3 | 0 | 67 | |
| GSE54994 | LGR4 | 55366 | 4 | 11 | 38 | |
| GSE60625 | LGR4 | 55366 | 0 | 0 | 11 | |
| GSE74703 | LGR4 | 55366 | 1 | 3 | 32 | |
| GSE74704 | LGR4 | 55366 | 0 | 8 | 12 | |
| TCGA | LGR4 | 55366 | 13 | 24 | 59 |
Total number of gains: 34; Total number of losses: 83; Total Number of normals: 371.
Somatic mutations of LGR4:
Generating mutation plots.
Highly correlated genes for LGR4:
Showing top 20/986 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGR4 | TAF9B | 0.720226 | 3 | 0 | 3 |
| LGR4 | TMEM161B | 0.719312 | 4 | 0 | 4 |
| LGR4 | BBIP1 | 0.697642 | 6 | 0 | 5 |
| LGR4 | STXBP5 | 0.692319 | 6 | 0 | 5 |
| LGR4 | TMEM38A | 0.69224 | 3 | 0 | 3 |
| LGR4 | ZNF585A | 0.688865 | 4 | 0 | 3 |
| LGR4 | C9orf85 | 0.684474 | 3 | 0 | 3 |
| LGR4 | PDZD11 | 0.679838 | 3 | 0 | 3 |
| LGR4 | SYNE2 | 0.678685 | 3 | 0 | 3 |
| LGR4 | COG6 | 0.670571 | 5 | 0 | 3 |
| LGR4 | VAV3 | 0.667555 | 7 | 0 | 7 |
| LGR4 | THUMPD3 | 0.666533 | 3 | 0 | 3 |
| LGR4 | ZNF300 | 0.664734 | 3 | 0 | 3 |
| LGR4 | TMEM186 | 0.660236 | 3 | 0 | 3 |
| LGR4 | ZNF563 | 0.657243 | 4 | 0 | 4 |
| LGR4 | ALDH9A1 | 0.657135 | 10 | 0 | 9 |
| LGR4 | PSENEN | 0.655991 | 4 | 0 | 3 |
| LGR4 | NPAS2 | 0.655112 | 5 | 0 | 4 |
| LGR4 | PDE12 | 0.654099 | 5 | 0 | 3 |
| LGR4 | SAMD9L | 0.653027 | 3 | 0 | 3 |
For details and further investigation, click here
