| Full name: presenilin enhancer, gamma-secretase subunit | Alias Symbol: PEN2 | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 55851 | HGNC ID: HGNC:30100 | Ensembl Gene: ENSG00000205155 | OMIM ID: 607632 |
| Related drugs: AVAGACESTAT, BEGACESTAT, CHEMBL247471, CHEMBL480558, NIROGACESTAT, PINITOL, SEMAGACESTAT, TARENFLURBIL... [more] | |||
Screen Evidence:
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PSENEN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of PSENEN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSENEN | 55851 | 218302_at | 0.0008 | 0.9989 | |
| GSE20347 | PSENEN | 55851 | 218302_at | -0.8792 | 0.0004 | |
| GSE23400 | PSENEN | 55851 | 218302_at | -0.2580 | 0.0075 | |
| GSE26886 | PSENEN | 55851 | 218302_at | -0.7168 | 0.0057 | |
| GSE29001 | PSENEN | 55851 | 218302_at | -0.4293 | 0.3485 | |
| GSE38129 | PSENEN | 55851 | 218302_at | -0.2712 | 0.2793 | |
| GSE45670 | PSENEN | 55851 | 218302_at | 0.1038 | 0.5732 | |
| GSE53622 | PSENEN | 55851 | 19668 | -0.0122 | 0.8914 | |
| GSE53624 | PSENEN | 55851 | 19668 | -0.0404 | 0.5454 | |
| GSE63941 | PSENEN | 55851 | 218302_at | 0.2335 | 0.7406 | |
| GSE77861 | PSENEN | 55851 | 218302_at | -0.2722 | 0.3766 | |
| GSE97050 | PSENEN | 55851 | A_24_P48587 | 0.3038 | 0.3717 | |
| SRP007169 | PSENEN | 55851 | RNAseq | -0.4921 | 0.4722 | |
| SRP008496 | PSENEN | 55851 | RNAseq | -0.8401 | 0.0518 | |
| SRP064894 | PSENEN | 55851 | RNAseq | 0.2521 | 0.4633 | |
| SRP133303 | PSENEN | 55851 | RNAseq | 0.1440 | 0.4894 | |
| SRP159526 | PSENEN | 55851 | RNAseq | -0.1000 | 0.6915 | |
| SRP193095 | PSENEN | 55851 | RNAseq | -0.3733 | 0.0061 | |
| SRP219564 | PSENEN | 55851 | RNAseq | -0.4332 | 0.1987 | |
| TCGA | PSENEN | 55851 | RNAseq | 0.1408 | 0.0417 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSENEN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSENEN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSENEN | 55851 | 7 | 4 | 19 | |
| GSE20123 | PSENEN | 55851 | 7 | 3 | 20 | |
| GSE43470 | PSENEN | 55851 | 3 | 7 | 33 | |
| GSE46452 | PSENEN | 55851 | 48 | 1 | 10 | |
| GSE47630 | PSENEN | 55851 | 9 | 5 | 26 | |
| GSE54993 | PSENEN | 55851 | 17 | 3 | 50 | |
| GSE54994 | PSENEN | 55851 | 6 | 9 | 38 | |
| GSE60625 | PSENEN | 55851 | 9 | 0 | 2 | |
| GSE74703 | PSENEN | 55851 | 3 | 4 | 29 | |
| GSE74704 | PSENEN | 55851 | 6 | 1 | 13 | |
| TCGA | PSENEN | 55851 | 22 | 10 | 64 |
Total number of gains: 137; Total number of losses: 47; Total Number of normals: 304.
Somatic mutations of PSENEN:
Generating mutation plots.
Highly correlated genes for PSENEN:
Showing top 20/600 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSENEN | ACAD9 | 0.823239 | 3 | 0 | 3 |
| PSENEN | STT3B | 0.798524 | 3 | 0 | 3 |
| PSENEN | MAP7 | 0.769087 | 3 | 0 | 3 |
| PSENEN | NARF | 0.750987 | 3 | 0 | 3 |
| PSENEN | PDIK1L | 0.745295 | 3 | 0 | 3 |
| PSENEN | RPP38 | 0.73375 | 3 | 0 | 3 |
| PSENEN | TMCO4 | 0.730374 | 3 | 0 | 3 |
| PSENEN | NAA20 | 0.725751 | 3 | 0 | 3 |
| PSENEN | GTF2IRD1 | 0.725602 | 3 | 0 | 3 |
| PSENEN | MRPS18C | 0.722501 | 4 | 0 | 3 |
| PSENEN | ARFIP1 | 0.721405 | 4 | 0 | 4 |
| PSENEN | FBXL5 | 0.719666 | 4 | 0 | 4 |
| PSENEN | TMEM147 | 0.716632 | 12 | 0 | 12 |
| PSENEN | RCHY1 | 0.712769 | 3 | 0 | 3 |
| PSENEN | NHSL1 | 0.711372 | 3 | 0 | 3 |
| PSENEN | WNK1 | 0.702359 | 4 | 0 | 4 |
| PSENEN | RFX1 | 0.700252 | 3 | 0 | 3 |
| PSENEN | COPE | 0.697589 | 4 | 0 | 4 |
| PSENEN | SLC35C2 | 0.696647 | 3 | 0 | 3 |
| PSENEN | SLC10A7 | 0.693954 | 3 | 0 | 3 |
For details and further investigation, click here
