| Full name: transmembrane protein 186 | Alias Symbol: DKFZP564K2062 | ||
| Type: protein-coding gene | Cytoband: 16p13.2 | ||
| Entrez ID: 25880 | HGNC ID: HGNC:24530 | Ensembl Gene: ENSG00000184857 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM186:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM186 | 25880 | 204676_at | 0.0497 | 0.9498 | |
| GSE20347 | TMEM186 | 25880 | 204676_at | 0.0458 | 0.7485 | |
| GSE23400 | TMEM186 | 25880 | 204676_at | 0.0516 | 0.3493 | |
| GSE26886 | TMEM186 | 25880 | 204676_at | -0.5308 | 0.0100 | |
| GSE29001 | TMEM186 | 25880 | 204676_at | 0.3249 | 0.2030 | |
| GSE38129 | TMEM186 | 25880 | 204676_at | 0.1291 | 0.2276 | |
| GSE45670 | TMEM186 | 25880 | 204676_at | 0.2199 | 0.0705 | |
| GSE53622 | TMEM186 | 25880 | 119314 | 0.1031 | 0.2135 | |
| GSE53624 | TMEM186 | 25880 | 119314 | 0.3572 | 0.0001 | |
| GSE63941 | TMEM186 | 25880 | 204676_at | 0.7488 | 0.0285 | |
| GSE77861 | TMEM186 | 25880 | 204676_at | -0.1945 | 0.3754 | |
| GSE97050 | TMEM186 | 25880 | A_23_P26687 | 0.0678 | 0.7831 | |
| SRP007169 | TMEM186 | 25880 | RNAseq | 1.0080 | 0.0882 | |
| SRP008496 | TMEM186 | 25880 | RNAseq | 0.7645 | 0.0618 | |
| SRP064894 | TMEM186 | 25880 | RNAseq | 0.1518 | 0.5688 | |
| SRP133303 | TMEM186 | 25880 | RNAseq | 0.3886 | 0.0832 | |
| SRP159526 | TMEM186 | 25880 | RNAseq | 0.2002 | 0.4872 | |
| SRP193095 | TMEM186 | 25880 | RNAseq | 0.0395 | 0.7303 | |
| SRP219564 | TMEM186 | 25880 | RNAseq | 0.4078 | 0.4117 | |
| TCGA | TMEM186 | 25880 | RNAseq | 0.0650 | 0.4115 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMEM186 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM186:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM186 | 25880 | 4 | 4 | 22 | |
| GSE20123 | TMEM186 | 25880 | 4 | 3 | 23 | |
| GSE43470 | TMEM186 | 25880 | 3 | 2 | 38 | |
| GSE46452 | TMEM186 | 25880 | 38 | 1 | 20 | |
| GSE47630 | TMEM186 | 25880 | 13 | 6 | 21 | |
| GSE54993 | TMEM186 | 25880 | 3 | 5 | 62 | |
| GSE54994 | TMEM186 | 25880 | 5 | 9 | 39 | |
| GSE60625 | TMEM186 | 25880 | 4 | 0 | 7 | |
| GSE74703 | TMEM186 | 25880 | 3 | 2 | 31 | |
| GSE74704 | TMEM186 | 25880 | 2 | 1 | 17 | |
| TCGA | TMEM186 | 25880 | 21 | 12 | 63 |
Total number of gains: 100; Total number of losses: 45; Total Number of normals: 343.
Somatic mutations of TMEM186:
Generating mutation plots.
Highly correlated genes for TMEM186:
Showing top 20/540 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM186 | LIMK2 | 0.770847 | 3 | 0 | 3 |
| TMEM186 | STAU1 | 0.770656 | 3 | 0 | 3 |
| TMEM186 | MAP4K5 | 0.766848 | 3 | 0 | 3 |
| TMEM186 | MORN2 | 0.765618 | 3 | 0 | 3 |
| TMEM186 | FRMD6 | 0.759779 | 3 | 0 | 3 |
| TMEM186 | LZIC | 0.754037 | 3 | 0 | 3 |
| TMEM186 | LRRC28 | 0.74952 | 3 | 0 | 3 |
| TMEM186 | CYLD | 0.731635 | 3 | 0 | 3 |
| TMEM186 | SPIN4 | 0.731357 | 3 | 0 | 3 |
| TMEM186 | OSBPL2 | 0.731092 | 4 | 0 | 3 |
| TMEM186 | SAP30L | 0.730368 | 3 | 0 | 3 |
| TMEM186 | SPNS1 | 0.727644 | 3 | 0 | 3 |
| TMEM186 | B9D2 | 0.726876 | 3 | 0 | 3 |
| TMEM186 | NDUFS1 | 0.723639 | 3 | 0 | 3 |
| TMEM186 | RRAGC | 0.722603 | 4 | 0 | 3 |
| TMEM186 | RBMX2 | 0.721533 | 3 | 0 | 3 |
| TMEM186 | PITHD1 | 0.720228 | 4 | 0 | 3 |
| TMEM186 | UBIAD1 | 0.720046 | 3 | 0 | 3 |
| TMEM186 | CASP4 | 0.71876 | 3 | 0 | 3 |
| TMEM186 | PPP2R5E | 0.717202 | 3 | 0 | 3 |
For details and further investigation, click here
