Full name: vav guanine nucleotide exchange factor 3	Alias Symbol:
Type: protein-coding gene	Cytoband: 1p13.3
Entrez ID: 10451	HGNC ID: HGNC:12659	Ensembl Gene: ENSG00000134215	OMIM ID: 605541
Drug and gene relationship at DGIdb

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VAV3 involved pathways:

KEGG pathway	Description	View
hsa04024	cAMP signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04510	Focal adhesion	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04664	Fc epsilon RI signaling pathway	View
hsa04666	Fc gamma R-mediated phagocytosis	View
hsa04670	Leukocyte transendothelial migration	View
hsa04810	Regulation of actin cytoskeleton	View

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Expression of VAV3:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	VAV3	10451	218807_at	-1.2415	0.0700	Show
GSE20347	VAV3	10451	218807_at	-2.1848	0.0000	Show
GSE23400	VAV3	10451	218807_at	-1.2241	0.0000	Show
GSE26886	VAV3	10451	218807_at	-2.3166	0.0006	Show
GSE29001	VAV3	10451	218807_at	-1.3175	0.0034	Show
GSE38129	VAV3	10451	218807_at	-1.6302	0.0022	Show
GSE45670	VAV3	10451	218807_at	-0.6705	0.1175	Show
GSE63941	VAV3	10451	218807_at	3.9307	0.0072	Show
GSE77861	VAV3	10451	218807_at	-2.0798	0.0002	Show
GSE97050	VAV3	10451	A_23_P201551	-0.1798	0.7602	Show
SRP007169	VAV3	10451	RNAseq	-4.1187	0.0000	Show
SRP008496	VAV3	10451	RNAseq	-3.3663	0.0000	Show
SRP064894	VAV3	10451	RNAseq	-1.8571	0.0000	Show
SRP133303	VAV3	10451	RNAseq	-1.4951	0.0000	Show
SRP159526	VAV3	10451	RNAseq	-3.3127	0.0000	Show
SRP193095	VAV3	10451	RNAseq	-1.7531	0.0000	Show
SRP219564	VAV3	10451	RNAseq	-1.4246	0.1053	Show
TCGA	VAV3	10451	RNAseq	-0.0383	0.8020	Show

Upregulated datasets: 1; Downregulated datasets: 12.  Download Data

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Survival by VAV3 expression:

 

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Copy number change of VAV3:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	VAV3	10451	0	11	19	Show
GSE20123	VAV3	10451	0	11	19	Show
GSE43470	VAV3	10451	0	7	36	Show
GSE46452	VAV3	10451	2	2	55	Show
GSE47630	VAV3	10451	9	5	26	Show
GSE54993	VAV3	10451	0	1	69	Show
GSE54994	VAV3	10451	7	4	42	Show
GSE60625	VAV3	10451	0	0	11	Show
GSE74703	VAV3	10451	0	6	30	Show
GSE74704	VAV3	10451	0	7	13	Show
TCGA	VAV3	10451	8	26	62	Show

Total number of gains: 26; Total number of losses: 80; Total Number of normals: 382.  Download Data

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Somatic mutations of VAV3:

 

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Highly correlated genes for VAV3:

 

Showing top 20/1343 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
VAV3	RASSF5	0.828113	5	0	5
VAV3	ATP13A4	0.819892	4	0	4
VAV3	EPS8L2	0.790782	8	0	8
VAV3	S100A16	0.781208	5	0	5
VAV3	VPS13D	0.768526	8	0	8
VAV3	SFTA2	0.763199	4	0	4
VAV3	FAM3D	0.762818	5	0	5
VAV3	RAET1E	0.761835	4	0	4
VAV3	KLF8	0.759296	9	0	9
VAV3	SYTL1	0.755566	6	0	6
VAV3	CLIC3	0.752833	9	0	9
VAV3	GRN	0.749754	8	0	8
VAV3	SUMF1	0.74801	3	0	3
VAV3	CST11	0.746916	3	0	3
VAV3	CYP3A5	0.745543	8	0	8
VAV3	SERPINB1	0.744634	9	0	9
VAV3	DUOX1	0.743251	10	0	10
VAV3	CYP2J2	0.742375	9	0	9
VAV3	BNIPL	0.740007	5	0	5
VAV3	PLEKHA7	0.73986	6	0	6

For details and further investigation, click here