| Full name: aldehyde dehydrogenase 9 family member A1 | Alias Symbol: E3 | ||
| Type: protein-coding gene | Cytoband: 1q24.1 | ||
| Entrez ID: 223 | HGNC ID: HGNC:412 | Ensembl Gene: ENSG00000143149 | OMIM ID: 602733 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ALDH9A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH9A1 | 223 | 201612_at | -0.8209 | 0.0695 | |
| GSE20347 | ALDH9A1 | 223 | 201612_at | -1.8570 | 0.0000 | |
| GSE23400 | ALDH9A1 | 223 | 201612_at | -1.2281 | 0.0000 | |
| GSE26886 | ALDH9A1 | 223 | 201612_at | -1.8252 | 0.0000 | |
| GSE29001 | ALDH9A1 | 223 | 201612_at | -1.2434 | 0.0000 | |
| GSE38129 | ALDH9A1 | 223 | 201612_at | -1.3662 | 0.0000 | |
| GSE45670 | ALDH9A1 | 223 | 201612_at | -0.9576 | 0.0024 | |
| GSE53622 | ALDH9A1 | 223 | 67015 | -1.6729 | 0.0000 | |
| GSE53624 | ALDH9A1 | 223 | 67015 | -1.7643 | 0.0000 | |
| GSE63941 | ALDH9A1 | 223 | 201612_at | -0.9888 | 0.0023 | |
| GSE77861 | ALDH9A1 | 223 | 201612_at | -1.6042 | 0.0007 | |
| GSE97050 | ALDH9A1 | 223 | A_24_P385280 | -1.2307 | 0.1012 | |
| SRP007169 | ALDH9A1 | 223 | RNAseq | -3.4598 | 0.0000 | |
| SRP008496 | ALDH9A1 | 223 | RNAseq | -2.9873 | 0.0000 | |
| SRP064894 | ALDH9A1 | 223 | RNAseq | -1.9633 | 0.0000 | |
| SRP133303 | ALDH9A1 | 223 | RNAseq | -2.0899 | 0.0000 | |
| SRP159526 | ALDH9A1 | 223 | RNAseq | -1.3226 | 0.0000 | |
| SRP193095 | ALDH9A1 | 223 | RNAseq | -1.9454 | 0.0000 | |
| SRP219564 | ALDH9A1 | 223 | RNAseq | -1.3256 | 0.0000 | |
| TCGA | ALDH9A1 | 223 | RNAseq | -0.1628 | 0.0103 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by ALDH9A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH9A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH9A1 | 223 | 10 | 2 | 18 | |
| GSE20123 | ALDH9A1 | 223 | 10 | 2 | 18 | |
| GSE43470 | ALDH9A1 | 223 | 7 | 2 | 34 | |
| GSE46452 | ALDH9A1 | 223 | 2 | 1 | 56 | |
| GSE47630 | ALDH9A1 | 223 | 14 | 0 | 26 | |
| GSE54993 | ALDH9A1 | 223 | 0 | 5 | 65 | |
| GSE54994 | ALDH9A1 | 223 | 16 | 0 | 37 | |
| GSE60625 | ALDH9A1 | 223 | 0 | 0 | 11 | |
| GSE74703 | ALDH9A1 | 223 | 7 | 2 | 27 | |
| GSE74704 | ALDH9A1 | 223 | 4 | 1 | 15 | |
| TCGA | ALDH9A1 | 223 | 44 | 3 | 49 |
Total number of gains: 114; Total number of losses: 18; Total Number of normals: 356.
Somatic mutations of ALDH9A1:
Generating mutation plots.
Highly correlated genes for ALDH9A1:
Showing top 20/1463 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH9A1 | KRT78 | 0.8758 | 7 | 0 | 7 |
| ALDH9A1 | SFTA2 | 0.860732 | 4 | 0 | 4 |
| ALDH9A1 | TMPRSS11B | 0.848707 | 7 | 0 | 7 |
| ALDH9A1 | CRISP3 | 0.848567 | 11 | 0 | 11 |
| ALDH9A1 | CYSRT1 | 0.841591 | 6 | 0 | 6 |
| ALDH9A1 | GYS2 | 0.835398 | 10 | 0 | 10 |
| ALDH9A1 | SH3BGRL2 | 0.831981 | 7 | 0 | 7 |
| ALDH9A1 | HPGD | 0.830199 | 11 | 0 | 11 |
| ALDH9A1 | CCNG2 | 0.829494 | 11 | 0 | 11 |
| ALDH9A1 | A2ML1 | 0.829221 | 7 | 0 | 7 |
| ALDH9A1 | SAMD5 | 0.828871 | 7 | 0 | 7 |
| ALDH9A1 | SNORA68 | 0.827176 | 4 | 0 | 4 |
| ALDH9A1 | SASH1 | 0.82592 | 12 | 0 | 12 |
| ALDH9A1 | NUCB2 | 0.824453 | 12 | 0 | 11 |
| ALDH9A1 | FCHO2 | 0.822535 | 7 | 0 | 7 |
| ALDH9A1 | RAET1E | 0.816209 | 6 | 0 | 6 |
| ALDH9A1 | CLCA4 | 0.813588 | 11 | 0 | 11 |
| ALDH9A1 | CXCR2 | 0.81335 | 11 | 0 | 11 |
| ALDH9A1 | CLIC3 | 0.812173 | 9 | 0 | 9 |
| ALDH9A1 | FAM214A | 0.811724 | 6 | 0 | 6 |
For details and further investigation, click here
