| Full name: LIM homeobox 6 | Alias Symbol: LHX6.1 | ||
| Type: protein-coding gene | Cytoband: 9q33.2 | ||
| Entrez ID: 26468 | HGNC ID: HGNC:21735 | Ensembl Gene: ENSG00000106852 | OMIM ID: 608215 |
| Drug and gene relationship at DGIdb | |||
Expression of LHX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LHX6 | 26468 | 219884_at | 0.8596 | 0.0567 | |
| GSE20347 | LHX6 | 26468 | 219884_at | 0.2549 | 0.0470 | |
| GSE23400 | LHX6 | 26468 | 219884_at | -0.0138 | 0.7941 | |
| GSE26886 | LHX6 | 26468 | 219884_at | 0.4383 | 0.1448 | |
| GSE29001 | LHX6 | 26468 | 219884_at | 0.3793 | 0.0674 | |
| GSE38129 | LHX6 | 26468 | 219884_at | 0.0632 | 0.7493 | |
| GSE45670 | LHX6 | 26468 | 219884_at | -0.0941 | 0.7737 | |
| GSE53622 | LHX6 | 26468 | 61942 | -0.1286 | 0.3955 | |
| GSE53624 | LHX6 | 26468 | 61942 | 0.2428 | 0.1196 | |
| GSE63941 | LHX6 | 26468 | 219884_at | 1.3483 | 0.1201 | |
| GSE77861 | LHX6 | 26468 | 224556_s_at | -0.0521 | 0.7186 | |
| GSE97050 | LHX6 | 26468 | A_23_P32175 | 0.2938 | 0.2361 | |
| SRP064894 | LHX6 | 26468 | RNAseq | 1.3341 | 0.0001 | |
| SRP133303 | LHX6 | 26468 | RNAseq | -0.2115 | 0.5058 | |
| SRP159526 | LHX6 | 26468 | RNAseq | 0.8630 | 0.0420 | |
| SRP219564 | LHX6 | 26468 | RNAseq | 0.6297 | 0.3253 | |
| TCGA | LHX6 | 26468 | RNAseq | -0.4141 | 0.0520 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LHX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LHX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LHX6 | 26468 | 3 | 7 | 20 | |
| GSE20123 | LHX6 | 26468 | 3 | 7 | 20 | |
| GSE43470 | LHX6 | 26468 | 5 | 4 | 34 | |
| GSE46452 | LHX6 | 26468 | 6 | 13 | 40 | |
| GSE47630 | LHX6 | 26468 | 3 | 16 | 21 | |
| GSE54993 | LHX6 | 26468 | 3 | 3 | 64 | |
| GSE54994 | LHX6 | 26468 | 9 | 10 | 34 | |
| GSE60625 | LHX6 | 26468 | 0 | 0 | 11 | |
| GSE74703 | LHX6 | 26468 | 5 | 3 | 28 | |
| GSE74704 | LHX6 | 26468 | 2 | 5 | 13 | |
| TCGA | LHX6 | 26468 | 27 | 24 | 45 |
Total number of gains: 66; Total number of losses: 92; Total Number of normals: 330.
Somatic mutations of LHX6:
Generating mutation plots.
Highly correlated genes for LHX6:
Showing top 20/81 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LHX6 | PGS1 | 0.7497 | 3 | 0 | 3 |
| LHX6 | LINC01305 | 0.656288 | 3 | 0 | 3 |
| LHX6 | ZNF8 | 0.654436 | 3 | 0 | 3 |
| LHX6 | FUOM | 0.637656 | 4 | 0 | 3 |
| LHX6 | TINAGL1 | 0.634441 | 3 | 0 | 3 |
| LHX6 | ETNK2 | 0.633451 | 3 | 0 | 3 |
| LHX6 | FBXO2 | 0.633286 | 3 | 0 | 3 |
| LHX6 | TNNT3 | 0.632286 | 3 | 0 | 3 |
| LHX6 | TPRA1 | 0.631522 | 4 | 0 | 3 |
| LHX6 | KDF1 | 0.631315 | 4 | 0 | 3 |
| LHX6 | FANCG | 0.629379 | 4 | 0 | 3 |
| LHX6 | C16orf91 | 0.625562 | 3 | 0 | 3 |
| LHX6 | KIR3DL1 | 0.618563 | 3 | 0 | 3 |
| LHX6 | RPP25 | 0.614781 | 6 | 0 | 4 |
| LHX6 | HRK | 0.611658 | 4 | 0 | 3 |
| LHX6 | C8orf44 | 0.607325 | 3 | 0 | 3 |
| LHX6 | PTRH1 | 0.602885 | 4 | 0 | 3 |
| LHX6 | SYNPO | 0.601796 | 5 | 0 | 3 |
| LHX6 | ABCA2 | 0.598909 | 3 | 0 | 3 |
| LHX6 | ZXDC | 0.597869 | 4 | 0 | 3 |
For details and further investigation, click here
