| Full name: ATP binding cassette subfamily A member 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 20 | HGNC ID: HGNC:32 | Ensembl Gene: ENSG00000107331 | OMIM ID: 600047 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCA2 | 20 | 212772_s_at | 0.3563 | 0.6292 | |
| GSE20347 | ABCA2 | 20 | 212772_s_at | 0.0258 | 0.7957 | |
| GSE23400 | ABCA2 | 20 | 212772_s_at | -0.0942 | 0.0705 | |
| GSE26886 | ABCA2 | 20 | 210100_s_at | 0.0262 | 0.8413 | |
| GSE29001 | ABCA2 | 20 | 212772_s_at | -0.0338 | 0.9104 | |
| GSE38129 | ABCA2 | 20 | 212772_s_at | -0.0554 | 0.4937 | |
| GSE45670 | ABCA2 | 20 | 212772_s_at | -0.1146 | 0.1919 | |
| GSE53622 | ABCA2 | 20 | 36331 | -0.0298 | 0.8302 | |
| GSE53624 | ABCA2 | 20 | 36331 | 0.2050 | 0.0274 | |
| GSE63941 | ABCA2 | 20 | 212772_s_at | 0.4418 | 0.1741 | |
| GSE77861 | ABCA2 | 20 | 210100_s_at | -0.0445 | 0.7409 | |
| GSE97050 | ABCA2 | 20 | A_23_P43504 | -0.1893 | 0.4877 | |
| SRP007169 | ABCA2 | 20 | RNAseq | 2.0301 | 0.0095 | |
| SRP008496 | ABCA2 | 20 | RNAseq | 2.0915 | 0.0001 | |
| SRP064894 | ABCA2 | 20 | RNAseq | 0.0072 | 0.9731 | |
| SRP133303 | ABCA2 | 20 | RNAseq | -0.2024 | 0.2728 | |
| SRP159526 | ABCA2 | 20 | RNAseq | 0.6837 | 0.1154 | |
| SRP193095 | ABCA2 | 20 | RNAseq | 0.6754 | 0.0009 | |
| SRP219564 | ABCA2 | 20 | RNAseq | 0.5182 | 0.2756 | |
| TCGA | ABCA2 | 20 | RNAseq | -0.4547 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ABCA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCA2 | 20 | 5 | 7 | 18 | |
| GSE20123 | ABCA2 | 20 | 5 | 7 | 18 | |
| GSE43470 | ABCA2 | 20 | 3 | 7 | 33 | |
| GSE46452 | ABCA2 | 20 | 6 | 13 | 40 | |
| GSE47630 | ABCA2 | 20 | 6 | 15 | 19 | |
| GSE54993 | ABCA2 | 20 | 3 | 3 | 64 | |
| GSE54994 | ABCA2 | 20 | 12 | 8 | 33 | |
| GSE60625 | ABCA2 | 20 | 0 | 0 | 11 | |
| GSE74703 | ABCA2 | 20 | 3 | 5 | 28 | |
| GSE74704 | ABCA2 | 20 | 3 | 5 | 12 | |
| TCGA | ABCA2 | 20 | 29 | 23 | 44 |
Total number of gains: 75; Total number of losses: 93; Total Number of normals: 320.
Somatic mutations of ABCA2:
Generating mutation plots.
Highly correlated genes for ABCA2:
Showing top 20/287 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCA2 | C19orf25 | 0.7907 | 3 | 0 | 3 |
| ABCA2 | DNAL4 | 0.79049 | 3 | 0 | 3 |
| ABCA2 | PPM1J | 0.788542 | 3 | 0 | 3 |
| ABCA2 | RAB40B | 0.787721 | 3 | 0 | 3 |
| ABCA2 | GYPE | 0.772858 | 3 | 0 | 3 |
| ABCA2 | ZC3H10 | 0.754457 | 3 | 0 | 3 |
| ABCA2 | ARMC7 | 0.748147 | 4 | 0 | 4 |
| ABCA2 | SYT2 | 0.730408 | 3 | 0 | 3 |
| ABCA2 | RGP1 | 0.723243 | 3 | 0 | 3 |
| ABCA2 | RLN3 | 0.717982 | 3 | 0 | 3 |
| ABCA2 | IGFN1 | 0.715124 | 3 | 0 | 3 |
| ABCA2 | BEND7 | 0.714865 | 3 | 0 | 3 |
| ABCA2 | SPACA3 | 0.710767 | 3 | 0 | 3 |
| ABCA2 | RASL10B | 0.709967 | 3 | 0 | 3 |
| ABCA2 | ADAM21 | 0.704795 | 4 | 0 | 3 |
| ABCA2 | PTGDR2 | 0.702809 | 4 | 0 | 3 |
| ABCA2 | RNF123 | 0.701802 | 4 | 0 | 4 |
| ABCA2 | FFAR1 | 0.699275 | 3 | 0 | 3 |
| ABCA2 | HOXD9 | 0.695851 | 3 | 0 | 3 |
| ABCA2 | PKLR | 0.694665 | 5 | 0 | 5 |
For details and further investigation, click here
