| Full name: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 | Alias Symbol: cl-2|NKB1|cl-11|nkat3|NKB1B|AMB11|CD158e1/2|CD158E1|CD158e2 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 3811 | HGNC ID: HGNC:6338 | Ensembl Gene: ENSG00000167633 | OMIM ID: 604946 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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KIR3DL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of KIR3DL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIR3DL1 | 3811 | 211687_x_at | 0.2292 | 0.2979 | |
| GSE20347 | KIR3DL1 | 3811 | 211687_x_at | 0.0417 | 0.7474 | |
| GSE23400 | KIR3DL1 | 3811 | 211687_x_at | -0.0520 | 0.0771 | |
| GSE26886 | KIR3DL1 | 3811 | 211687_x_at | 0.0466 | 0.6055 | |
| GSE29001 | KIR3DL1 | 3811 | 211687_x_at | -0.2300 | 0.0726 | |
| GSE38129 | KIR3DL1 | 3811 | 211687_x_at | -0.0962 | 0.4123 | |
| GSE45670 | KIR3DL1 | 3811 | 211687_x_at | 0.0648 | 0.5446 | |
| GSE53622 | KIR3DL1 | 3811 | 46454 | 0.5284 | 0.0000 | |
| GSE53624 | KIR3DL1 | 3811 | 46454 | 0.4841 | 0.0000 | |
| GSE63941 | KIR3DL1 | 3811 | 211687_x_at | 0.0412 | 0.8177 | |
| GSE77861 | KIR3DL1 | 3811 | 211687_x_at | 0.0140 | 0.9149 | |
| GSE97050 | KIR3DL1 | 3811 | A_24_P117147 | 0.5896 | 0.4078 | |
| TCGA | KIR3DL1 | 3811 | RNAseq | 1.3681 | 0.3458 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KIR3DL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIR3DL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIR3DL1 | 3811 | 3 | 4 | 23 | |
| GSE20123 | KIR3DL1 | 3811 | 3 | 3 | 24 | |
| GSE43470 | KIR3DL1 | 3811 | 3 | 11 | 29 | |
| GSE46452 | KIR3DL1 | 3811 | 45 | 1 | 13 | |
| GSE47630 | KIR3DL1 | 3811 | 8 | 6 | 26 | |
| GSE54993 | KIR3DL1 | 3811 | 17 | 4 | 49 | |
| GSE54994 | KIR3DL1 | 3811 | 4 | 13 | 36 | |
| GSE60625 | KIR3DL1 | 3811 | 9 | 0 | 2 | |
| GSE74703 | KIR3DL1 | 3811 | 3 | 7 | 26 | |
| GSE74704 | KIR3DL1 | 3811 | 3 | 1 | 16 | |
| TCGA | KIR3DL1 | 3811 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of KIR3DL1:
Generating mutation plots.
Highly correlated genes for KIR3DL1:
Showing top 20/404 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIR3DL1 | CA7 | 0.706245 | 5 | 0 | 5 |
| KIR3DL1 | ART1 | 0.706105 | 4 | 0 | 4 |
| KIR3DL1 | LUZP4 | 0.689819 | 5 | 0 | 5 |
| KIR3DL1 | FGR | 0.686393 | 4 | 0 | 4 |
| KIR3DL1 | COTL1 | 0.67868 | 3 | 0 | 3 |
| KIR3DL1 | CD300LF | 0.672012 | 3 | 0 | 3 |
| KIR3DL1 | CRISP1 | 0.666919 | 4 | 0 | 4 |
| KIR3DL1 | RFPL3 | 0.657754 | 5 | 0 | 5 |
| KIR3DL1 | NEUROD2 | 0.655943 | 4 | 0 | 4 |
| KIR3DL1 | KIR3DL3 | 0.651998 | 8 | 0 | 8 |
| KIR3DL1 | KIR2DS2 | 0.649365 | 8 | 0 | 7 |
| KIR3DL1 | CYP4A11 | 0.646266 | 6 | 0 | 6 |
| KIR3DL1 | CYP2A7 | 0.64049 | 6 | 0 | 5 |
| KIR3DL1 | ERC2-IT1 | 0.640069 | 5 | 0 | 3 |
| KIR3DL1 | KRT76 | 0.637518 | 4 | 0 | 4 |
| KIR3DL1 | OR1A1 | 0.637097 | 5 | 0 | 4 |
| KIR3DL1 | ERN1 | 0.636358 | 5 | 0 | 4 |
| KIR3DL1 | CHAT | 0.63535 | 6 | 0 | 5 |
| KIR3DL1 | TMEM239 | 0.634355 | 3 | 0 | 3 |
| KIR3DL1 | RAI1 | 0.630931 | 6 | 0 | 5 |
For details and further investigation, click here
