| Full name: peptidyl-tRNA hydrolase 1 homolog | Alias Symbol: PTH1 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 138428 | HGNC ID: HGNC:27039 | Ensembl Gene: ENSG00000187024 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PTRH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTRH1 | 138428 | 228014_at | 0.4646 | 0.0719 | |
| GSE26886 | PTRH1 | 138428 | 228014_at | 0.5054 | 0.0206 | |
| GSE45670 | PTRH1 | 138428 | 228014_at | 0.5536 | 0.0036 | |
| GSE53622 | PTRH1 | 138428 | 39886 | 0.3381 | 0.0011 | |
| GSE53624 | PTRH1 | 138428 | 39886 | 0.6833 | 0.0000 | |
| GSE63941 | PTRH1 | 138428 | 228014_at | 0.3628 | 0.4510 | |
| GSE77861 | PTRH1 | 138428 | 228014_at | 0.1330 | 0.3990 | |
| GSE97050 | PTRH1 | 138428 | A_33_P3220643 | 0.2045 | 0.4269 | |
| SRP007169 | PTRH1 | 138428 | RNAseq | 0.8617 | 0.1050 | |
| SRP008496 | PTRH1 | 138428 | RNAseq | 1.0562 | 0.0111 | |
| SRP064894 | PTRH1 | 138428 | RNAseq | 1.5184 | 0.0002 | |
| SRP133303 | PTRH1 | 138428 | RNAseq | 0.5327 | 0.0004 | |
| SRP159526 | PTRH1 | 138428 | RNAseq | 0.4301 | 0.0804 | |
| SRP193095 | PTRH1 | 138428 | RNAseq | 0.5554 | 0.0003 | |
| SRP219564 | PTRH1 | 138428 | RNAseq | 0.3686 | 0.3434 | |
| TCGA | PTRH1 | 138428 | RNAseq | 0.1581 | 0.1179 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PTRH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTRH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTRH1 | 138428 | 6 | 9 | 15 | |
| GSE20123 | PTRH1 | 138428 | 6 | 9 | 15 | |
| GSE43470 | PTRH1 | 138428 | 5 | 6 | 32 | |
| GSE46452 | PTRH1 | 138428 | 6 | 13 | 40 | |
| GSE47630 | PTRH1 | 138428 | 4 | 15 | 21 | |
| GSE54993 | PTRH1 | 138428 | 3 | 3 | 64 | |
| GSE54994 | PTRH1 | 138428 | 11 | 8 | 34 | |
| GSE60625 | PTRH1 | 138428 | 0 | 0 | 11 | |
| GSE74703 | PTRH1 | 138428 | 5 | 4 | 27 | |
| GSE74704 | PTRH1 | 138428 | 3 | 7 | 10 | |
| TCGA | PTRH1 | 138428 | 27 | 25 | 44 |
Total number of gains: 76; Total number of losses: 99; Total Number of normals: 313.
Somatic mutations of PTRH1:
Generating mutation plots.
Highly correlated genes for PTRH1:
Showing top 20/404 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTRH1 | UBTF | 0.757262 | 3 | 0 | 3 |
| PTRH1 | MRPS17 | 0.720542 | 4 | 0 | 4 |
| PTRH1 | MAD2L1 | 0.690183 | 3 | 0 | 3 |
| PTRH1 | YKT6 | 0.669522 | 4 | 0 | 4 |
| PTRH1 | CCNF | 0.657254 | 4 | 0 | 3 |
| PTRH1 | NTMT1 | 0.652697 | 7 | 0 | 7 |
| PTRH1 | MIIP | 0.65257 | 3 | 0 | 3 |
| PTRH1 | DNASE1L2 | 0.652175 | 3 | 0 | 3 |
| PTRH1 | SMC2 | 0.650436 | 3 | 0 | 3 |
| PTRH1 | UQCC1 | 0.64702 | 3 | 0 | 3 |
| PTRH1 | RRP9 | 0.64587 | 6 | 0 | 5 |
| PTRH1 | ADIRF-AS1 | 0.643455 | 3 | 0 | 3 |
| PTRH1 | CEP41 | 0.643116 | 4 | 0 | 4 |
| PTRH1 | MED20 | 0.642082 | 5 | 0 | 4 |
| PTRH1 | TUBA1C | 0.638648 | 3 | 0 | 3 |
| PTRH1 | AURKB | 0.636859 | 3 | 0 | 3 |
| PTRH1 | MMP10 | 0.634274 | 4 | 0 | 4 |
| PTRH1 | USB1 | 0.633917 | 6 | 0 | 5 |
| PTRH1 | KRT9 | 0.632771 | 4 | 0 | 4 |
| PTRH1 | NEK2 | 0.628269 | 3 | 0 | 3 |
For details and further investigation, click here
